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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Predictors Of Discrepancies Between Informants’ Ratings Of Preschool-Aged Children’S Behavior: An Examination Of Ethnicity, Child Characteristics, And Family Functioning, Elizabeth Harvey, Candice Fischer, Julie L. Weieneth, Sara D. Hurwitz, Aline G. Sayer
Predictors Of Discrepancies Between Informants’ Ratings Of Preschool-Aged Children’S Behavior: An Examination Of Ethnicity, Child Characteristics, And Family Functioning, Elizabeth Harvey, Candice Fischer, Julie L. Weieneth, Sara D. Hurwitz, Aline G. Sayer
Elizabeth (Lisa) Harvey
The present study examined predictors of discrepancies between mothers’, fathers’, and teachers’ ratings of 3-year-old children’s hyperactivity, attention problems, and aggression. Participants were families of 196 3-year-old children who took part in child and family assessments. Ethnicity was one of the most consistent predictors of discrepancies. African American mothers and fathers were more likely to rate their children’s hyperactivity, attention problems, and aggression lower than teachers. In contrast, Latina mothers were more likely to rate their children as more hyperactive and inattentive than teachers. ADHD/ODD diagnoses, parental depression, number of children, and children’s pre-academic skills were also predictive of discrepancies …
The Longitudinal Relation Between Academic/Cognitive Skills And Externalizing Behavior Problems In Preschool Children, Lindsay A. Metcalfe, Elizabeth Harvey, Holly B. Laws
The Longitudinal Relation Between Academic/Cognitive Skills And Externalizing Behavior Problems In Preschool Children, Lindsay A. Metcalfe, Elizabeth Harvey, Holly B. Laws
Elizabeth (Lisa) Harvey
Objective—Existing research suggests that there is a relation between academic/cognitive deficits and externalizing behavior in young children, but the direction of this relation is unclear. The present study tested competing models of the relation between academic/cognitive functioning and behavior problems during early childhood Method—Participants were 221 children (120 boys, 101 girls) who participated in a longitudinal study from age 3 to 6 Results—A reciprocal relation (Model 3) was observed only between inattention and academic achievement; this relation remained controlling for SES and family stress. The relation between inattention and cognitive ability was consistent with Model 1 (cognitive skills predicting later …
Aging And The Perception Of Temporally-Interleaved Words, Karen S. Helfer, Christine R. Mason, Christine Marino
Aging And The Perception Of Temporally-Interleaved Words, Karen S. Helfer, Christine R. Mason, Christine Marino
Karen S Helfer
No abstract provided.
Grammatical Treamtment And Specific Language Impairment: Neighborhood Density & Third Person Singular -S, Jill R. Hoover, Holly L. Storkel
Grammatical Treamtment And Specific Language Impairment: Neighborhood Density & Third Person Singular -S, Jill R. Hoover, Holly L. Storkel
Jill R. Hoover
The purpose of this study was to test the effect of manipulating verb neighbourhood density in treatment targeting the third person singular lexical affix. Using a single-subject experimental design, six pre-schoolers with Specific Language Impairment (SLI) were randomly assigned to one of two conditions: (1) treatment with sparse verbs or (2) treatment with dense verbs in 12 sessions. The third person singular lexical affix was targeted for 12 sessions of treatment in both conditions. Treatment gain and generalization were measured as the dependent variables. Third person singular % correct change from pre-treatment to post-treatment was measured using sentence production tasks …
Perturbation Of Brachypodium Distachyon Cellulose Synthase A4 Or 7 Results In Abnormal Cell Walls, Pubudu P. Handakumbura, Dominick A. Matos, Karen S. Osmont, Michael J. Harrington, Kyuyoung Heo, Kabindra Kafle, Seong H. Kim, Tobias Baskin, Samuel P. Hazen
Perturbation Of Brachypodium Distachyon Cellulose Synthase A4 Or 7 Results In Abnormal Cell Walls, Pubudu P. Handakumbura, Dominick A. Matos, Karen S. Osmont, Michael J. Harrington, Kyuyoung Heo, Kabindra Kafle, Seong H. Kim, Tobias Baskin, Samuel P. Hazen
Tobias Baskin
Background: Cellulose is an integral component of the plant cell wall and accounts for approximately forty percent of total plant biomass but understanding its mechanism of synthesis remains elusive. CELLULOSE SYNTHASE A (CESA) proteins function as catalytic subunits of a rosette-shaped complex that synthesizes cellulose at the plasma membrane. Arabidopsis thaliana and rice (Oryza sativa) secondary wall CESA loss-of-function mutants have weak stems and irregular or thin cell walls. Results: Here, we identify candidates for secondary wall CESAs in Brachypodium distachyon as having similar amino acid sequence and expression to those characterized in A. thaliana, namely CESA4/7/8. To functionally characterize …
Modeling Colorectal Cancer As A 3-Dimensional Disease In A Dish: The Case For Drug Screening Using Organoids, Zebrafish, And Fruit Flies, Michele Markstein
Modeling Colorectal Cancer As A 3-Dimensional Disease In A Dish: The Case For Drug Screening Using Organoids, Zebrafish, And Fruit Flies, Michele Markstein
Michele Markstein
This review discusses recent shifts in the understanding of colorectal cancer as a stem cell based disease, based on findings that tie patient prognosis to the presence of cancer stem cells in colorectal tumors. Currently no drugs specifically target CSCs in colorectal tumors. However, recent advances in the culturing of colorectal stem cells using mammalian organoids, zebrafish, and Drosophila offer promising avenues for anti-CSC drug discovery.
Oncogenic Transformation Of Mammary Epithelial Cells By Transforming Growth Factor Beta Independent Of Mammary Stem Cell Regulation, Karen Dunphy, Jae-Hong Seo, Daniel J. Kim, Amy L. Roberts, Luwei Tao, James Direnzo, Amanda L. Balboni, Giovanna M. Crisi, Mary J. Hagen, Thiruppavai Chandrasekaran, Kelly J. Gauger, Sallie Smith Schneider, D Joseph Jerry
Oncogenic Transformation Of Mammary Epithelial Cells By Transforming Growth Factor Beta Independent Of Mammary Stem Cell Regulation, Karen Dunphy, Jae-Hong Seo, Daniel J. Kim, Amy L. Roberts, Luwei Tao, James Direnzo, Amanda L. Balboni, Giovanna M. Crisi, Mary J. Hagen, Thiruppavai Chandrasekaran, Kelly J. Gauger, Sallie Smith Schneider, D Joseph Jerry
Karen Dunphy
Background: Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce an oncogenic epithelial to mesenchymal transition (EMT) program in permissive cells and initiate the generation of cancer stem cells. Our objective is to mimic the transient exposure to TGFβ during involution to determine the persistent effects on premalignant mammary epithelium. Method: CDβGeo cells, a transplantable mouse mammary epithelial cell line, were treated in vitro for 14 days with TGFβ (5 ng/ml). The cells were passaged for an additional …
Oncogenic Transformation Of Mammary Epithelial Cells By Transforming Growth Factor Beta Independent Of Mammary Stem Cell Regulation, Karen A. Dunphy, Jae-Hong Seo, Daniel J. Kim, Amy L. Roberts, Luwei Tao, James Direnzo, Amanda L. Balboni, Giovanna M. Crisi, Mary J. Hagen, Thiruppavai Chandrasekaran, Kelly J. Gauger, Sallie Smith Schneider, D. Joseph Jerry
Oncogenic Transformation Of Mammary Epithelial Cells By Transforming Growth Factor Beta Independent Of Mammary Stem Cell Regulation, Karen A. Dunphy, Jae-Hong Seo, Daniel J. Kim, Amy L. Roberts, Luwei Tao, James Direnzo, Amanda L. Balboni, Giovanna M. Crisi, Mary J. Hagen, Thiruppavai Chandrasekaran, Kelly J. Gauger, Sallie Smith Schneider, D. Joseph Jerry
D. Joseph Jerry
Background: Transforming growth factor beta (TGFβ) is transiently increased in the mammary gland during involution and by radiation. While TGFβ normally has a tumour suppressor role, prolonged exposure to TGFβ can induce an oncogenic epithelial to mesenchymal transition (EMT) program in permissive cells and initiate the generation of cancer stem cells. Our objective is to mimic the transient exposure to TGFβ during involution to determine the persistent effects on premalignant mammary epithelium. Method: CDβGeo cells, a transplantable mouse mammary epithelial cell line, were treated in vitro for 14 days with TGFβ (5 ng/ml). The cells were passaged for an additional …
Racial Disparities In Us Infant Birth Outcomes: A Protective Effect Of Military Affiliation?, Jennifer H. Lundquist
Racial Disparities In Us Infant Birth Outcomes: A Protective Effect Of Military Affiliation?, Jennifer H. Lundquist
Dr. Jennifer H. Lundquist
Research has been unable to determine why African Americans have higher infant mortality and preterm birth prevalence than whites, even taking into account measurable social and economic differences. This is, in part, due to the difficulty of adequately measuring the impacts of racial inequality and residential segregation. As an alternative approach, this paper comparatively examines infant outcomes among military-affiliated and civilian black and white women. The military setting provides higher-than-average economic equality and universal healthcare access. Although military-affiliated populations are usually left out of most major datasets, we construct a new variable that allows us to identify military affiliation using …