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Full-Text Articles in Medicine and Health Sciences
The Prevalence And Identity Of Chlamydia-Specific Ige In Children With Asthma And Other Chronic Respiratory Symptoms, Katir K. Patel, Erica A. Anderson, Paul S. Salva, Wilmore C. Webley
The Prevalence And Identity Of Chlamydia-Specific Ige In Children With Asthma And Other Chronic Respiratory Symptoms, Katir K. Patel, Erica A. Anderson, Paul S. Salva, Wilmore C. Webley
Wilmore C Webley
Background Recent studies have confirmed the presence of viable Chlamydia in the bronchoalveolar lavage (BAL) fluid of pediatric patients with airway hyperresponsiveness. While specific IgG and IgM responses to C. pneumoniae are well described, the response and potential contribution of Ag-specific IgE are not known. The current study sought to determine if infection with Chlamydia triggers the production of pathogen-specific IgE in children with chronic respiratory diseases which might contribute to inflammation and pathology.
Methods We obtained BAL fluid and serum from pediatric respiratory disease patients who were generally unresponsive to corticosteroid treatment as well as sera from age-matched control …
Detection Of Chlamydia In The Peripheral Blood Cells Of Normal Donors Using In Vitro Culture, Immunofluorescence Microscopy And Flow Cytometry Techniques, Frances Cirino, Wilmore Webley, Corrie West, Nancy L. Croteau, Chester Andrzejewski Jr., Elizabeth S. Stuart
Detection Of Chlamydia In The Peripheral Blood Cells Of Normal Donors Using In Vitro Culture, Immunofluorescence Microscopy And Flow Cytometry Techniques, Frances Cirino, Wilmore Webley, Corrie West, Nancy L. Croteau, Chester Andrzejewski Jr., Elizabeth S. Stuart
Wilmore C Webley
BACKGROUND: Chlamydia trachomatis (Ct) and Chlamydia pneumoniae (Cp) are medically significant infectious agents associated with various chronic human pathologies. Nevertheless, specific roles in disease progression or initiation are incompletely defined. Both pathogens infect established cell lines in vitro and polymerase chain reaction (PCR) has detected Chlamydia DNA in various clinical specimens as well as in normal donor peripheral blood monocytes (PBMC). However, Chlamydia infection of other blood cell types, quantification of Chlamydia infected cells in peripheral blood and transmission of this infection in vitro have not been examined.
METHODS: Cp specific titers were assessed for sera from 459 normal human …