Medicine and Health Sciences Commons^™

The Impaired Bone Anabolic Effect Of Pth In The Absence Of Endogenous Fgf2 Is Partially Due To Reduced Atf4 Expression, Yurong Fei, Liping Xiao, Marja M. Hurley

UCHC Articles - Research

Parathyroid hormone (PTH) is currently the only approved anabolic agent for osteoporosis pharmacotherapy in the USA. However, the molecular and cellular mechanisms underlying which intermittent PTH stimulates bone formation are not fully established.

Activating transcription factor 4 (ATF4) was recently identified to be a downstream target of PTH signaling in osteoblasts and FGF2 is able to rapidly increase ATF4 mRNA and protein expression in osteoblasts. Furthermore, ATF4 expression is markedly reduced in Fgf2−/− osteoblasts. In addition, FGF2 is required for the anabolic action of PTH on bone formation. Therefore, we hypothesize that the impaired anabolic effect of PTH in Fgf2−/− …

Dietary Protein And Skeletal Health: A Review Of Recent Human Research, Jane E. Kerstette, Anne M. Kenny

UCHC Articles - Research

Purpose of review

Both dietary calcium and vitamin D are undoubtedly beneficial to skeletal health. In contrast, despite intense investigation, the impact of dietary protein on calcium metabolism and bone balance remains controversial. A widely held view is that high intakes of animal protein result in increased bone resorption, reduced bone mineral density, and increased fractures because of its ability to generate a high fixed metabolic acid load. The purpose of this review is to present the recent or most important epidemiological and clinical trials in humans that evaluated dietary protein’s impact on skeletal health.

Recent findings

Many epidemiological studies …