Medicine and Health Sciences Commons^™

Interpersonal Guilt And Substance Use In College Students, Nancy M. Petry

UCHC Articles - Research

The college years are a time for developing independence and separating from one’s family, and it is also a time in which substance use often escalates. This study examined the relationships between use of substances and interpersonal guilt, an emotion that can arise from feelings about separation, among 1,979 college students. Regular users of alcohol, cigarettes, cannabis, and other illicit drugs were compared with non-regular users of each substance. Sequential linear regression, controlling for confounding variables, examined relationships between regular use of each substance and scores on a guilt index. Risky drinkers and daily smokers had significantly more interpersonal guilt …

Variation In Mu-Opioid Receptor Gene (Oprm1) As A Moderator Of Naltrexone Treatment To Reduce Heavy Drinking In A High Functioning Cohort, Jonathan M. Covault

UCHC Articles - Research

Background

It is well known that naltrexone, an FDA-approved medication for treatment of alcohol dependence, is effective for only a subset of individuals. Recent studies have examined the utility of a functional A118G single nucleotide polymorphism (SNP) of the mu-opioid receptor gene (OPRM1) as a predictor of naltrexone treatment response. Although the findings to date have generally been consistent with a moderating effect of the SNP, further evaluation of this hypothesis is warranted.

Objective

To evaluate whether problem drinkers with one or two copies of the 118G allele respond better to naltrexone treatment. The treatment goal in this cohort of …

Increased Drinking In A Trial Of Treatments For Marijuana Dependence: Substance Substitution?, Ronald M. Kadden, Mark D. Litt, Elise Kabela-Cormier, Nancy M. Petry

UCHC Articles - Research

This report examines whether participants in a study of treatments for marijuana dependence may have increased their use of alcohol when they reduced or ceased marijuana use. Participants were randomly assigned to one of four psychosocial treatments and followed at 3-month intervals for one-year. Findings are from 207 cases with data at posttreatment and at least one other follow-up. 73% of cases reported an increase of at least 10% in drinking days over their level at intake, and 65% reported an increase of at least 10% in drinks per drinking day. Drinking increases were not related to treatment condition nor …

Training Medical Providers To Conduct Alcohol Screening And Brief Interventions, Thomas F. Babor, John C. Higgins-Biddle, Pamela S. Higgins, Bruce E. Gould

UCHC Articles - Research

Although progress has been made in developing a scientific basis for alcohol screening and brief intervention (SBI), training packages are necessary for its widespread dissemination in primary care settings. This paper evaluates a training package developed for the Cutting Back^® SBI program. Three groups of medical personnel were compared before and after SBI training: physicians (n = 44), medical students (n = 88), and non-physicians (n = 41). Although the training effects were at times dependent on group membership, all changes were in a direction more conducive to implementing SBI. Physicians and medical students increased confidence in performing screening …