Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Age Related Changes In Craniofacial Morphology In Gdf-8 (Myostatin) Deficient Mice, Jeffrey Miller
Age Related Changes In Craniofacial Morphology In Gdf-8 (Myostatin) Deficient Mice, Jeffrey Miller
SoDM Articles
It is well recognized that masticatory muscle function helps determine morphology, although the extent of function on final form is still debated. GDF-8 (myostatin), a transcription factor is a negative regulator of skeletal muscle growth. A recent study has shown that mice homozygous for the myostatin mutation had increased muscle mass and craniofacial dysmorphology in adulthood. However, it is unclear whether such dysmorphology is present at birth. This study examines the onset and relationship between hypermuscularity and craniofacial morphology in neonatal and adult mice with GDF-8 deficiency.
Fifteen (8 wild-type and 7 GDF-8 −/−), 1 day old and 16 (9 …