Medicine and Health Sciences Commons^™

Extracting Patterns In Medical Claims Data For Predicting Opioid Overdose, Ryan Sanders

Graduate Theses and Dissertations

The goal of this project is to develop an efficient methodology for extracting features from time-dependent variables in transaction data. Transaction data is collected at varying time intervals making feature extraction more difficult. Unsupervised representational learning techniques are investigated, and the results compared with those from other feature engineering techniques. A successful methodology provides features that improve the accuracy of any machine learning technique. This methodology is then applied to insurance claims data in order to find features to predict whether a patient is at risk of overdosing on opioids. This data covers prescription, inpatient, and outpatient transactions. Features created …

The Impact Of Income On Nutrition. A Case Study Of Northern Mozambique, Hunter Swanigan

Agricultural Economics and Agribusiness Undergraduate Honors Theses

In 2017, Mozambique ranked as one of the least-developed countries in the world by measures of health, education, and income, and had one of the lowest GDP per capita at $1,300. With a minimal income, purchasing adequate food to meet recommended levels of nutrients for a healthy diet is difficult, leaving almost half of the country’s population undernourished. This study researched what foods are available during the dry months (hungry season) of May through October in the Nampula province of Mozambique to analyze if it is possible to meet the National Institutes of Health’s recommended levels of nutrients from purchasing …

Global Acetylation Dynamics In The Heat Shock Response Of Saccharomyces Cerevisiae, Rebecca E. Hardman

Graduate Theses and Dissertations

All organisms face a constant barrage of environmental stresses. Single-cell organisms such as Saccharomyces cerevisiae, or common Baker’s yeast, must rely solely on cellular responses in order to survive. This response must occur in a rapid and highly coordinated manner to quickly inhibit all unnecessary processes and shuttle all available resources to those necessary for survival. One method that cells utilize for rapid protein regulation is the use of post-translational modifications. Enzymes within the cell add or remove a variety of chemical modifications, thus altering the local chemical environment of a protein. This creates a conformational change in the protein …

Turn That Frown Upside-Down! The Effectiveness Of Opposite Action In Changing Emotion, Kaitlyn Diane Chamberlain

Graduate Theses and Dissertations

While research demonstrates that opposite action (OA) impacts emotion (Rizvi & Linehan, 2005), we lack an understanding of the mechanisms by which it produces opposite emotions. The current study dismantled emotion regulation skill components by comparing tasks with different combinations of cognitive, emotive and behavioral components. I predicted that the OA condition would be the most effective in altering negative emotion. University students (n = 194) completed a sadness induction and were randomly assigned to either a (1) control, (2) low arousal positive imagery (3) high arousal positive imagery, or (4) OA plus high arousal positive imagery condition. The control …

Methods To Evaluate Ruminant Animal Production Responses, Jose Manuel Diaz Gomez

Graduate Theses and Dissertations

In experiment 1, 80 steers (197.0 kg initial body weight; BW for fall, 116.9 kg for spring), were stocked at 2.45 and 4.1 calves/ha in fall and spring, respectively in 16 tall fescue pastures [fall ergovaline (EV) = 1,475 ppb and spring EV = 1,173 ppb] under 2 treatments, mineral (MIN) (n = 8) and cumulative management (CM) (n = 8). Forage allowance did not differ (P = 0.76) between CM and MIN during fall but differed during spring (P ≤ 0.05, 2.55 vs. 3.22 kg DM/kg BW, for MIN and CM, respectively). For fall, average daily gain (ADG) resulted …

Functional Importance Of Lipin Phosphorylation, Stephanie Elizabeth Hood

Graduate Theses and Dissertations

Highly conserved throughout evolution, lipins are dual functioning proteins found from yeast to humans. Functioning in the cytoplasm as phosphatidate phosphatase enzymes (PAP), lipins produce diacylglycerol that serves as a precursor for neutral fats and membrane phospholipids. Alternatively, nuclear lipins are responsible for the regulation of metabolic genes. Interestingly, both the mammalian lipin 1 paralog and the single Drosophila Lipin ortholog are highly phosphorylated proteins. Target of rapamycin (TOR) has previously been identified as one of the kinases that controls the subcellular localization of both lipin 1 and Drosophila Lipin. However, other serine and threonine kinases are predicted to be …

Probing Of Carbohydrate-Protein Interactions Using Galactonoamidine Inhibitors, Jessica B. Pickens

Graduate Theses and Dissertations

Glycoside hydrolases are ubiquitous and one of the most catalytically proficient enzymes known, and thus understanding their mechanisms are crucial. Most research has focused on the interaction of the glycon of substrates and their inhibitors within the active site of glycoside hydrolases. The inhibitors employed to probe these interactions generally had small aglycons (i.e. a hydrogen atom, amidines, small aliphatic groups, or benzyl groups). Here, the interactions of the aglycon with glycoside hydrolases are examined by probing the active sites with a library of 25 galactonoamidines. The studies described in this dissertation aim to increase the understanding of stabilization of …

Toward Understanding The Mechanism Of Protein Targeting In The Chloroplast Signal Recognition Particle Pathway, Mercede Furr

Graduate Theses and Dissertations

Protein targeting is a vital cellular function. The signal recognition particle (SRP) pathway is a universally conserved targeting system present in the cytosol and used to co-translationally target many proteins to the inner membrane of prokaryotes and the endoplasmic reticulum of eukaryotes. The chloroplast has a homologous SRP system which post-translationally targets light harvesting chlorophyll binding proteins (LHCPs) to the thylakoid membrane for integration. The chloroplast SRP (cpSRP) is a heterodimer with a 54 kDa subunit equivalent to SRP54 in the canonical pathway. In addition, cpSRP contains a novel 43 kDa subunit which is a unique and irreplaceable component. cpSRP43 …

Estimation Of Genetic Components Related To Infectious Bovine Keratoconjunctivitis Susceptibility In Angus And Angus Derived Cattle Produced In The Southern United States, Eric Oxford

Graduate Theses and Dissertations

The economic impact of infectious bovine keratoconjunctivitis (IBK) has been documented in many parts of the world. Many researchers have observed that prevention of this disease is very difficult given current methodologies. This is primarily due to the multifactorial nature of this disease. The objective of this dissertation was to determine the impact of IBK on calf performance and estimate genetic parameters, heritability and estimated breeding values for IBK susceptibility. Data were analyzed using PROC GLIMMIX of SAS; while genetic parameters were estimated using a linear animal model for both single- and two-traits through MTDFREML. Additional evaluations calculated heritability using …

Quantitative Study Of The Antimicrobial Effects Of Silver On The Motility Of Escherichia Coli, Benjamin Russell

Graduate Theses and Dissertations

In recent decades, the number of antibiotic-resistant bacterial infections has grown to become a serious global threat. This rise can be attributed to the widespread misuse of antibiotics and the lack of newly developed drugs to fight resistant organisms. Novel bactericidal substances have, therefore, garnered significant research interest. Silver, due to its powerful antimicrobial effects, is one such substance. Silver is typically most effective in cationic form; however, advancements in nanotechnology have paved the way for the controlled fabrication of nano-silver. Silver nanoparticles have been shown to have increased antibacterial potency for a variety of reasons, including the release of …

Production And Purification Of Basic Fibroblast Growth Factor Fused To Two Collagen Binding Domains Expressed In E. Coli Bl21 Using Flask And Fed-Batch, Hazim Aljewari

Graduate Theses and Dissertations

Delivering effective and non-toxic doses of bioactive materials that can aid in activating tissue regeneration to wounded tissue has proven to be an enormous challenge. This study was designed to produce a potential therapeutic recombinant protein by fusing two collagen binding domains to basic fibroblast growth factors (bFGF) through a collagenase cleavage site linker, so it can release the bFGF in a wound site by the action of this enzyme. The novel fusion protein was expressed in Escherichia coli BL-21 (E. coli) using traditional flask shaker and fed-batch cultivation. Cell lysate was purified by FPLC using Immobilized metal affinity chromatography …

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Ulnar Collateral Ligament Reconstruction (UCLR) is a surgical procedure on one of the main ligaments that provides normal stability for the elbow joint against excessive valgus stress. Damage to this ligament is common in athletes performing overhead throwing activities, primarily baseball players, due to excessive valgus stress during the throwing motion. The most common form of treatment for this type of injury is reconstructive surgery of the ligament, especially if athletes wish to return to sport participation. This type of surgery is extremely invasive and requires extensive post-operative rehabilitation in order to facilitate return to play. To date, many …

Determining Whether A Spot Urine Sample Is An Accurate Indication Of A Person's Hydration Status, Hannah Glidewell

Health, Human Performance and Recreation Undergraduate Honors Theses

The purpose of this study was to determine what technique would be an accurate measurement of an individual’s hydration status. According to current research on hydration assessment, the “gold standard” to assess the hydration of an individual is by measuring their total body water (Armstrong, Lawrence 2007). This is the most accurate measurement in a laboratory setting, but finding a measurement that works during a real time setting has been a challenge. It was proposed that a spot urine sample would provide more accurate results than a first- morning urine sample when compared to a 24-hour urine sample set as …

Does Pre-Pregnancy Bmi Predict Transfer To A Hospital From A Birth Center For Pain Management?, Audrey Fleenor

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background:Birth centers are staffed predominantly by midwives and nurses who care for a patient population consisting of low-risk pregnancies. The American Association of Birth Centers requires that the birth center has an agreement with a local hospital to transfer patients if need-be before, during or after delivery in case any complications arise that may result in needing alternative care (Rathbun, 2017). The rate of obesity in the United States has been rising for years. Obesity affects overall health as well as a woman’s pregnancy and pregnancy outcomes. Overall, an obese individual does not prioritize physical exercise and lacks healthy …

Cardiology Student Nurse Internship, Chimdera Nzelu

The Eleanor Mann School of Nursing Undergraduate Honors Theses

This past summer and into my final semester in the Eleanor Mann School of Nursing, I became a student nurse intern at Washington Regional Medical Center in the Cardiology department. Heart disease and other heart-related morbidities are on the rise within our population, especially as the baby-boomer generation continues to age – and healthcare must follow suit. The Cardiology department combined with the Walker Heart Institute of Washington Regional is a champion within Northwest Arkansas for the best care related to the heart, and I had the incredible opportunity to serve and learn from their talented healthcare team. Through my …

Washington Regional Student Nurse Internship-Cardiology, Lillie Watson

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The Student Nurse Internship Program was started as a way to allow nursing students to gain the skill set of patient care and communication while allowing us additional educational opportunities. The first 4 weeks of my internship were the orientation period in which 2 weeks we followed a nurse and then the other 2 weeks we followed a nursing assistant. These initial 4 weeks really gave us the opportunity to have educational opportunities by following the nurse, but also allowing us to work with another nursing assistant before working on our own. Through my internship at Washington Regional, I was …

Addressing Barriers To Maternal Healthcare For Marshallese Islanders In Northwest Arkansas: An Internship Experience, Victoria Richardson

The Eleanor Mann School of Nursing Undergraduate Honors Theses

The Marshallese community is a rapidly growing population in Northwest Arkansas. Approximately 12,000 people migrated from the Marshall Islands and settled in the state of Arkansas due to the signing of the Compact of Free Association (COFA) in 1986. Although the population in Northwest Arkansas is experiencing rapid growth, there are significant health disparities that coincide with it. Due to vast cultural differences, language barriers, low economic status, and political barriers, the Marshallese community suffers from prenatal health inequalities and poor maternal and fetal outcomes, including low birth-weight infants, premature births, and increased infant mortality. During my internship, I provided …

Implementing A Community-Based Breastfeeding And Infant Support Tent At University Of Arkansas Athletic Events, Moranda Clark

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Breastfeeding is such an important role in a mother and baby’s relationship as it establishes a unique bond while also providing health benefits for both parties involved. Unfortunately, many women are discriminated against for trying to breastfeed in public and with little to no designated breastfeeding areas or sanitary places in such spaces; they are left with very few viable options. During the last year I have been completing an internship surrounding the subject of breastfeeding and have helped to implement a breastfeeding and infant support tent at University of Arkansas athletic events. My work has included extensive research, lactation …

Willow Creek Women's Hospital Internship, Destinee Ross

The Eleanor Mann School of Nursing Undergraduate Honors Theses

While the use of midwifery is proven to improve outcomes for low-risk mothers and infants, many healthcare providers, nurses, and patients in Northwest Arkansas continue to be skeptical about utilizing midwifery care. During my internship, I worked directly with labor and delivery nurses, physicians, and a midwife at Willow Creek Women’s Hospital and provided high-quality care to women during their birthing process. This hospital focuses entirely on women and infant care and provides gynecological, obstetric, and newborn services. Willow Creek Women’s Hospital is also one of the few hospitals in Arkansas to implement a certified nurse-midwife (CNM) and has two …

Exploring Perceptions And Attitudes Of Health In Marshallese Adolescents Who Are Overweight In Northwest Arkansas, Lauren Love

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Purpose

Childhood obesity is a growing public health problem in the United States. An increasing number of children are becoming overweight or obese and facing the negative health issues from this diagnosis. They might also suffer socially due to their weight because they are more likely to be bullied or picked on. This project explored the perceptions and attitudes of health in Marshallese adolescents that are overweight in Northwest Arkansas. The goal of our project was to investigate themes for commonality amongst adolescents that are overweight about how they perceive their weight and their beliefs towards health and body image. …

Effects Of A Double Mutation In The Heparin Binding Pocket On Hfgf-1, Vanessa Weidling

Chemical Engineering Undergraduate Honors Theses

The human acidic fibroblast growth factor (hFGF-1) is a protein that plays an important role in many body processes such as angiogenesis and tissue repair. As such, it has great potential for therapeutic application. However, hFGF-1 is relatively unstable in the body with a significant fraction being denatured at body temperature and pH. It contains a group of positively charged amino acids in close proximity that create an electrostatic strain on the molecule and can lead to denaturation and increased susceptibility to enzymatic digestion. Upon its release from the cell, hFGF-1 binds to the glycosaminoglycan heparin in the extracellular matrix. …

Created For Connection: The Impact Of A Faith-Based Christian Marriage Enrichment Program, Chad N. Imhoff

Graduate Theses and Dissertations

The purpose of this study was to explore the effects of Created for Connection (CFC), a faith based marriage enrichment program on relationship satisfaction, adult attachment style and adult attachment behavior. This study further adds to the existing knowledge base related to faith-based programs delivered in an intensive weekend format (Johnson & Sanderfer, 2016). Participants were volunteers from the local community who identified as Christian. To ascertain the effectiveness of CFC, three self-report measures were administered at three different intervals: two weeks before the program, two weeks following the program and a six-week follow-up. I measured attachment anxiety, attachment avoidance, …

Influence Of Single And Multiple Histidine Residues And Their Ionization Properties On Transmembrane Helix Dynamics, Orientations And Fraying, Fahmida Afrose

Graduate Theses and Dissertations

Since aromatic and charged residues are often present in various locations of transmembrane helices of integral membrane proteins, their impacts on the molecular properties of transmembrane proteins and their interactions with lipids are of particular interest in many studies. In this work, I used solid-state deuterium NMR spectroscopy in designed model peptide GWALP23 [GGALW(LA)6LWLAGA] with selective deuterium labels to addresses the pH dependence and influence of single and multiple “guest” histidine residues in the orientation and dynamic behaviors of transmembrane proteins. The mutations include Gly to His (G2/22 to H2/22), Trp to His (W5/19 to H5/19) and Leu to His …

Components Of Mindfulness Training: Impacts On Attention And Affect, Maximilian Fey

Graduate Theses and Dissertations

The literature on mindfulness supports a distinction between two components of non-judgmental acceptance and directed attention. The present research analyzed whether there are distinct differences in attentional capabilities or affect between mindfulness inductions which differed in either including only directed attention or directed attention and non-judgmental acceptance. I hypothesized that the acceptance component of mindfulness would increase participants sustained attentional capabilities relative to a control condition; furthermore, I hypothesized that the non-judgmental acceptance component of mindfulness would lead to significant increases in positive affect and decreases in negative affect relative to control. Lastly, I hypothesized that an individual difference measure …

Investigating Egg Storage Conditions, Hatch Characteristics, And Feeding Methods Of Commercially Produced Poultry, Joshua R. Deines

Graduate Theses and Dissertations

Advancements in poultry research continue to add knowledge and understanding to an already technical industry. Such information has led to new developments in early feeding strategies which provide nutrients to broiler chicks while in the egg or during transport. This wealth of knowledge in poultry research extends beyond chickens and is utilized for other species, such as quail and pheasants, including how fertile eggs are stored and incubated. However, methods of early feeding broilers have not been investigated in industry relevant approaches to understand its effects, including how timing of feed access interacts with the hatch window. As well, quail …

Single Molecule Fluorescence Studies Of Protein Structure And Dynamics Underlying The Chloroplast Signal Recognition Particle Targeting Pathway, Dustin R. Baucom

Graduate Theses and Dissertations

The work presented in this dissertation explores the structural dynamics in the chloroplast signal recognition particle pathway. Findings include cpSRP shows scanning functionality similar to that in the cytosolic SRP with the ribosome. The intrinsically disordered C-terminal tail of the Albino3 protein has some transient secondary structure. Upon binding to cpSRP43 in solution, separate secondary structure formation was identified in the C-terminal tail of Albino3. Finally, to increase efficiency of analyzing fluorescence time traces for this work, a modular software was produced.

Development Of A Text Message Stress Management Intervention And Its Impact On Perceived Stress And Coping Self-Efficacy Among Student Nurses, Kristin Jaye Henderson

Graduate Theses and Dissertations

Purpose: The purpose of the two studies was to develop a text message intervention and examine its effects on lowering perceived stress and increasing coping self-efficacy among nursing students. We also explored stress perceptions and investigated student satisfaction with the text message stress management program. Methods: For the first study, twenty three students participated in the focus groups for intervention development. Sample messages were presented to participants and feedback was requested. The messages were modified based on student feedback. The second study utilized an experimental pre/post design with a convenience sample (N=101) to examine the effects of the text message …

The Acute Effect Of Water Intake On Glucose Regulation In Low Drinkers, Adam David Seal

Graduate Theses and Dissertations

Previous evidence suggests the hormone arginine vasopressin (AVP) may be a modifiable factor contributing to hyperglycemia. Significant differences in urine concentration and copeptin, a marker for AVP, have been observed between low and high water drinkers. Purpose: The purpose was to investigate the acute effect of adequate water intake on glucose regulation in low drinkers. Methods: 7 healthy (5 males, 2 female) low drinkers were recruited using a water frequency questionnaire (WFQ), spot and 24-h urine sample (age 43±6 y, BMI 30.9±3, WFQ volume 823±403 mL∙d-1, 24 h Uosm 961±105 mmol∙kg-1, copeptin 8.17±3.05 pmol∙L-1). During two experimental protocols, participants remained …

Social Anxiety Reduction In The Context Of Social Modeling Utilizing A Placebo Alcohol Beverage, Kyle K. Jackson

Graduate Theses and Dissertations

Alcohol misuse and elevated social anxiety are found to be highly comorbid, and being exposed to social models consuming alcohol can increase one’s consumption. Yet no research has thus far examined whether the internal experience of alcohol consumption (e.g., social anxiety reduction) can also be transmitted via social modeling. This bar-lab study examined the impact of social modeling behavioral cues of social anxiety on emerging adult drinkers. It was hypothesized that those exposed to a social model experiencing an apparent social anxiety reduction from drinking would themselves report lessened state social anxiety following a placebo drink, and that this effect …

Release Kinetics Of Methylene Blue In Pluronic F-127 Hydrogel, Meredith Hayden

Animal Science Undergraduate Honors Theses

“Between January 1998 and March 2000, veterinarians at the ASPCA National Animal Poison Control Center (NAPCC) consulted on more than 1,050 cases of accidental exposures to acetaminophen and 1,100 cases of ibuprofen ingestion in dogs and cats” (Richardson, 2000).

NSAID toxicity has become an increasingly common occurrence in small companion animals within the last decade due to widespread usage (Zhou, Boudreau, & Freedman, 2014). Depending on the specific drug, treatment is centered around early decontamination and prevention of kidney and hepatic damage, and methemoglobanemia. Currently, methemoglobanemia is treated with intravenous delivery of methylene blue and less commonly through oral administration. …