Medicine and Health Sciences Commons^™

Evaluation Of Two Neonatal Challenge Models For Broiler Chickens And Their Effects On Early Performance Parameters, Callie Selby

Graduate Theses and Dissertations

Formaldehyde fumigation in poultry hatch cabinets has been utilized for sanitation of hatching eggs for over a century. Formaldehyde is utilized to minimize pathogenic microbes on the surface of the egg as well as the microbial bloom during the hatching process. While formaldehyde is effective, its use is regulated in the United States and Europe due to its carcinogenic nature. Formaldehyde has been shown to damage the cuticle of the egg, cause embryonic death, and damage the epithelial lining of the respiratory tract of freshly hatched chicks, predisposing them for respiratory infection. Alternatives for formaldehyde fumigation must be identified and …

Stress Among Ncaa Division Ii Head Coaches, Dee Gerlach

Graduate Theses and Dissertations

The purpose of this quantitative study was to identify factors that create stress among head coaches at the National Association Athletic Association Division II level. Data was collected through a demographic questionnaire and the Coaching Issues Survey (CIS), a tool used to measure specific factors that may create stress among coaches. The factors of the CIS include four subscales: Athlete-Concerns, Time-Role, Program-Success, and Win-Loss. Participants (N=416) consisted of head coaches representing the following sports: baseball, men’s basketball, women’s basketball, men’s golf, women’s golf, men’s and women’s golf, softball, women’s tennis, and men’s and women’s tennis. The independent variables for this …

Does Whispering Improve Children’S Memory? Comparing Auditory Vigilance And Salience Hypotheses, Christina M. Barnes

Graduate Theses and Dissertations

Oral communication is one of the primary tools children use to learn new information and speech registers can deliver additional meaning to the words someone uses. Cirillo’s (2004) vigilance hypothesis states “Whispering can affect the psychobiological state of recipients, and in particular raise their auditory vigilance” (Cirillo, 2004, p. 76). Building on this theory, the current study investigates the role of whispering and children’s memory by examining a whispering vigilance, whispering salience which focused on the changes between normal and whisper registers, and combined vigilance and salience hypotheses to determine if whispering contributes to the recall of information. Using video …

The Impact Of Corporal Punishment For Timorese High School Graduates, Veronica Godinho Pereira

Graduate Theses and Dissertations

This research examines the impacts of corporal punishment for Timorese high school graduates. Physical punishment is a pervasive method of disciplining students and children used in Timor-Leste because it has been such a tradition (UNICEF 2017). Few researchers have attempted to analyze the negative impacts of corporal punishment and possible gender differences; there is no known research on the impacts of corporal punishment in Timor-Leste. This study uses an in-depth interview method, where data were collected from 26 Timorese high school graduates composed of both men and women from both private and public schools in Timor-Leste. The ages of the …

Effects Of Localized Oxygen Production By Electrolysis On The First-Generation Glucose Sensor Response, Nandita Halder

Graduate Theses and Dissertations

Glucose sensors are very important for detecting blood glucose both in vitro and in vivo. First-generation glucose biosensors were based on the glucose oxidase (GOx) enzyme using molecular oxygen as the electron acceptor and therefore oxygen dependent. Unfortunately for in-vivo work, oxygen in the body is variable and limited. Alternative approaches to overcome the oxygen dependency came with their own limitations. The widely used and commercially available ex-vivo glucose test strip uses a mediator in place of oxygen to free it from oxygen dependency. The mediator-based technology, in most cases cannot be transferred to in vivo applications due to the …

Substance Use And Psychological Distress Correlates Of Sleep Quality Among College Students, Juanybeth Morales Ortega

Graduate Theses and Dissertations

Poor sleep quality in college students is a major problem associated with adverse health outcomes, cognitive performance, substance use, and psychological distress. Our study explored how substance use and psychological distress are associated with the sleep quality of college students. We analyzed secondary data collected in 2019 using a cross-sectional survey design. Measures included participants’ demographic characteristics, sleep quality using the Pittsburg Sleep Quality Index (PSQI), drug use, depression using the Patient Health Questionnaire-9 (PHQ-9), and suicidality. After excluding participants with missing information for sleep quality, a total of 555 students remained for the analysis. Our bivariate analysis found that …

News Media Trust And Mistrust During The Covid-19 Pandemic, Kaitlyn Seiter

Graduate Theses and Dissertations

With the uncertainty and growing information surrounding the COVID-19 pandemic, news media consumption has increased drastically compared to pre-pandemic consumption. At the start of the pandemic, 94% of Americans reported closely following COVID-19 news, with more than half of Americans spending more than two hours consuming COVID-19 news everyday (SSRS, 2020). With the news media serving as a critical source of information through this public health crisis, the public’s reactions, behaviors, and attitudes to the pandemic stem from the level of trust they have in the news media to share COVID-19 information. Because of this, this study examines trust in …

Multifunctional Programmable Self-Assembled Nanoparticles In Nanomedicine, Yoshie Sakamaki

Graduate Theses and Dissertations

Developing methodologies to control the architecture of nanoparticles (NPs) at the atomic level prevents their inhomogeneity and leads to a variety of expected functions. Rationally designed nanoparticles can either be programmed or crystallized structures into pre-determined structures achieving tunable particle pore size and physiochemistry. In this dissertation, two broad classes of multifunctional nanoparticles are developed, metal-organic frameworks and DNA-NP aggregates.

Metal-organic frameworks are a novel class of highly porous crystalline materials built from organic linkers and metal cluster-based secondary building units. However, applications in bioremediation have not been developed very well especially in applications regarding drug delivery systems (DDS). The …

Data-Driven Statin Initiation Evaluation And Optimization For Prediabetes Population, Muhenned A. Abdulsahib

Graduate Theses and Dissertations

This dissertation develops quantitative models to support medical decision making of statininitiation considering the uncertainty in disease progression for prediabetes patients. A mathematical model is built to help medical decision-makers take action of statin initiation under uncertainty in future prediabetes progressions. The association between cholesterol drug use, such as statin, and elevating glucose level attracted considerable amounts of attention in the literature. Statin effects on glucose vary with respect to different levels of glucose. The first chapter of this dissertation introduces the problem and an overview of the tools that will be used to solve it. In the second chapter …

Investigation Of Histomoniasis Prevention In Poultry, Lesleigh Beer

Graduate Theses and Dissertations

Histomonas meleagridis is the etiological agent of histomoniasis, also commonly known as blackhead disease. This protozoal disease of poultry is detrimental to turkeys with flock mortalities often reaching 80-100%, although other gallinaceous birds are susceptible. Since the voluntary removal of nitarsone in 2015, the poultry industry is suffering with no approved prophylactics, therapeutics, or vaccines for this disease. The objectives of this dissertation were to evaluate multiple methods for prevention or control of histomoniasis, including dietary chemoprophylaxis and vaccination. Specifically, this research evaluated quinine as a chemoprophylactic candidate (Chapter 3) or live-attenuated H. meleagridis as vaccine candidates (Chapter 4) in …

Negative Urgency's Influence On State-Level, Emotion-Based Changes In Alcohol-Related Cognitions, Noah Wolkowicz

Graduate Theses and Dissertations

This project expanded on the Acquired Preparedness Model of Risk (APMR) by examining how Negative Urgency (NU), the tendency to act rashly in negative emotional states, affects emotion-based changes in alcohol cognitions to produce risk for alcohol use. The APMR prioritizes the role of outcome expectancies as the means through which traits such as NU, convey alcohol use risk. However, this model treats these cognitions as static and often fails to assess their valence; further, alcohol-cognitions fluctuate in response to negative emotions and may become more salient during these states. Therefore, this study examined: 1) how NU impacts negative emotion-based, …

Directed Genome Evolution To Identify Genes For Macrophage Survival By Staphylococcus Agnetis, Sonali Lakshika Anne Lenaduwe Lokuge

Graduate Theses and Dissertations

Bacterial Chondronecrosis with Osteomyelitis (BCO) is a debilitating infection that negatively impacts animal welfare and costs the broiler industry billions of dollars annually. We have previously isolated Staphylococcus agnetis 908 from BCO samples obtained from broilers at the University of Arkansas research farm. This isolate can induce BCO lameness at greater than 50% in broilers exposed to the pathogen in drinking water. We found that S. agnetis 908 is capable of surviving and escaping macrophages compared to a closely related cattle isolate,1379. Through Directed Genome Evolution (DGE) we identified that this difference is at least partially associated with an alanine …

Vulnerability To And Protection Against Covid-19 Fear, Threat, And Worry, Marsha Kim Huh

Graduate Theses and Dissertations

Drawing from a sample of 10,368 adults living in the U.S., the current study examines the role of social and psychological resources in lowering COVID-related fear, threat, and worry, controlling for a number of social vulnerabilities (e.g. gender, race/ethnicity, and presence of children). The impact of social location, particularly in regards to race, and how one accesses and/or utilizes social and psychological resources is also examined through disaggregated regression models. Results demonstrate that some social and psychological resources impact COVID-specific distress (fear/threat/worry), but depending on the resource, relationships vary in direction and significance. The strength of social ties and mastery …

Nanomaterial-Based Biosensors For Detection Of Salmonella Typhimurium And Avian Influenza Virus H5n1 In Poultry, Xinge Xi

Graduate Theses and Dissertations

This research focused on developing biosensing method and biosensing device for rapid detection of pathogens in poultry: Salmonella Typhimurium and avian influenza virus H5N1. The first part of the dissertation reports an original research on the development of a portable biosensing device for Salmonella detection. The device was designed and constructed based on a previously developed optical biosensing method, using immuno-magnetic nanoparticles to specifically capture target bacteria, and immuno-quantum dot beads to label the target bacteria for fluorescence detection. All the actions of sample mixing, magnetic separation, and fluorescence detection were controlled automatically in a disposable microfluidic chip in the …

Optimization Of Vaccine Supply Chains In Low- And Middle-Income Countries Utilizing Drones, Maximilian Kolter

Graduate Theses and Dissertations

Despite tremendous efforts from governments and humanitarian organizations, millions of children in low- and low-middle-income countries (LICs and LMICs) are still excluded from the benefits of immunization. The vaccine distribution in LICs and LMICs is challenging for several reasons, such as limited cold chain capacities, vaccine wastage, uncertain demand, and lack of access to immunization services. A promising avenue to address these issues is the utilization of drones for vaccine delivery. Drones can fly at high speed on direct paths and could enable on-demand deliveries to mitigate limited storage capacities. Further, their independence of road networks could allow them reaching …

The Co-Regulatory Effects Of Emotionally Focused Therapy, Julia Conroy

Graduate Theses and Dissertations

Mental health literature emphasizes the necessity of expanding emotional regulation to improve symptomology of a variety of mental health disorders. Coregulatory experiences have been shown to expand individual emotional regulation and are more likely in relationships with secure attachment. Emotionally Focused Therapy (EFT) is focused on developing secure attachment between partners. This study examined the coregulatory effects of EFT with a single couple over the course of couples’ counseling. The participating couple received eight couples’ counseling sessions from a clinician who is a certified EFT trainer, supervisor, and therapist while having their heart rate, electrodermal activity, and skin temperature taken …

Experimental And Analysis Of Electromagnetic Characterization Of Biological And Non-Biological Materials In Microwave, Millimeter-Wave, And Terahertz Frequency Bands, Nagma Vohra

Graduate Theses and Dissertations

The goal of this research is to characterize the electromagnetic properties of biological and non-biological materials at terahertz (THz), millimeter-wave, and microwave frequency bands. The biological specimens are measured using the THz imaging and spectroscopy system, whereas the non-biological materials are measured using the microwave and millimeter-wave free-space system. These facilities are located in the Engineering Research Center at the University of Arkansas. The THz imaging system (TPS 3000) uses a Ti-Sapphire laser directed on the photoconductive antennas to generate a THz time domain pulse. Upon using the Fourier Transform, the spectrum of the pulsed THz signal includes frequencies from …

A Time-Course Characterization Of Muscle Function And Mitochondrial Markers During Colorectal Cancer-Induced Cachexia In Tumor-Bearing Male Mice, Ana Cabrera Ayuso

Graduate Theses and Dissertations

Cachexia is a multisystemic and multifactorial syndrome prevalent in cancer patients. It is clinically defined by involuntary loss of >5% weight in a six-month window, despite nutritional interventions. A negative energy balance characterizes cancer cachexia (CC), it is associated with weakness and fatigue in skeletal muscle. Impaired muscle function is associated with lower quality of life in cancer patients. Defects in mitochondrial function are strongly associated with muscle wasting. This study explored muscular contractile function and mitochondrial quality control (MQC) markers in soleus, gastrocnemius, and tibialis anterior (TA) muscles of C26-induced male tumor-bearing mice during a 25-day time course. It …

The Balance Of Excitation And Inhibition And Its Influence On Cortical States And Rett Syndrome, Jingwen Li

Graduate Theses and Dissertations

Our brain consists of billions of neurons, properly coordinating to process information and realize brain functions. Among them, there are two types of neurons: excitatory neurons and inhibitory neurons. The firing of excitatory neurons increases the membrane potential of downstream neurons, and thus excites other neurons to fire. The firing of inhibitory neurons, in contrast, decreases the membrane potential of downstream neurons, and thus inhibits other neurons to fire. The interplay of excitatory and inhibitory neurons shape the spiking activity in the population. Thus, the `balance of excitation and inhibition' plays an important role in cortical processing and brain functions. …

Campus Mental Health Service Use Among Female Survivors Of Sexual Violence: An Interpretative Phenomenological Analysis, Hannah Coffman

Graduate Theses and Dissertations

Description: Despite the increase in resources to address the alarming rates of collegiate sexual violence (SV), survivors consistently do not disclose or seek mental health treatment from campus supports (Halstead et al., 2017). The purpose of this study was to understand the lived experiences of women who survived SV during college.

Method: Seven women who experienced SV during college completed a series of two semi-structured interviews using a HIPAA-compliant, web-conferencing software (Seidman, 2013). The interviews were transcribed verbatim and analyzed using an interpretative phenomenological analysis (IPA) framework (IPA; Smith, 2004; Smith et al., 2009). A six-step data analysis procedure identified …

Child-Centered Play Therapy’S Impact On Externalized Behaviors Of Children Who Have Experienced Trauma: A Single-Case Research Design, Timothy "T.J." Schoonover

Graduate Theses and Dissertations

Adverse childhood experiences (ACEs) are defined as exposure to emotional abuse, physical abuse, sexual abuse, emotional neglect, physical neglect, loss of a parent, domestic violence, family member with addiction, family member with depression or mental illness, and family member incarcerated (Felitti et al., 1998). ACEs have been studied for many years and have shown to have long term negative health and social-emotional outcomes and costs the world over $1 trillion a year (Bellis et al., 2019; Felitti et al., 1998; Hughes et al., 2017). Due to the emotional, physical, and dollar amount cost to not addressing the impact of ACEs …

Impact Of Covid-19 On The Severe Acute Malnutrition Admissions Among Children Under 5 Years Of Age Seeking Nutrition Services In Afghanistan, Sahar Sayedy

Graduate Theses and Dissertations

The purpose of the study was to assess the impact of COVID-19 on the number of admissions of severe acute malnutrition among children under 5 years of age seeking nutrition services in Afghanistan especially in the provinces where the prevalence of COVID-19 was high, for the period of February – September 2020. The study used comparison and analysis of secondary datasets of the Integrated Management of Acute Malnutrition – a national program for detection and management of moderate and severe acute malnutrition in the country.

This study analyzed the association between COVID-19 cases and severe acute malnutrition (SAM) admissions of …

An Adventure Therapy Mountain Bike Program For Middle School Students: A Pilot Study, Cian L. Brown

Graduate Theses and Dissertations

Adolescence is a time of significant physical, mental, emotional, and social development marked by numerous transitions and challenges. Middle school is one of the earliest and perhaps first times of significant social and physical transition that impacts early adolescent development. As a result, schools are becoming a primary care setting for children and families to identify and address mental health needs. However, only 2% of school mental health services are provided by licensed professionals. Therefore, schools and service providers continue to seek out comprehensive modalities that can efficiently provide preventative and responsive interventions to students beyond individual and school counseling …

Laughter As A Priming Agent For Change, Linnea M. Heintz

Graduate Theses and Dissertations

The purpose of this study was to analyze the importance of laughter as a factor in influencing employee job satisfaction ratings. The Job Satisfaction Survey (Spector, 1985, 1997) and pulses of laughter were used in this study. To explore the relationship between laughter and job satisfaction, results of the Job Satisfaction Survey (Spector, 1994) were collected quarterly (four times a year) for three consecutive years, beginning six months prior to the start of the two-year study and six months post. The study sample was composed of 545 employees (34% male, 66% female) operating out of 10 employee-owned retail chain locations …

I Matter: Understanding The Self-Care Practices Of School Counselors During The Covid-19 Pandemic And How Internal And External Factors Create Barriers, Alisha Rene Marie Jones

Graduate Theses and Dissertations

Diminished self-care practices and heightened stress of school counselors is a continuing problem in education. With role ambiguity, high student-to-counselor ratios, emotional exhaustion, and others adding pressure to the roles and responsibilities of school counselors, this study investigated the self-care practices of Missouri school counselors and the internal and external factors which influence them, specifically within the context COVID-19. Clayton Alderfer’s (1972) Existence, Relatedness, and Growth theory was used as a theoretical framework for chosen self-care practices represented in this study and was supported by Robert Kegan’s and Lisa Lahey’s (2009) Immunity to Change theory to understand the competing commitments …

Recovering From Substance Abuse In Arkansas: The Accessibility And Affordability Of Drug Treatment Programs, Whitney King

Graduate Theses and Dissertations

This thesis is going to examine how people recover from drug addiction and see if there are any similarities due to their socioeconomic statuses at the time of recovery. This research addresses the following questions: How accessible and affordable are drug addiction recovery programs and rehabilitation facilities in Arkansas for mid- to low-income individuals? What are the social costs for people who can’t obtain drug rehabilitation services? The goal of this research is to explore whether there is a lack of affordable recovery programs in the state of Arkansas. This project utilizes survey responses as well as in-depth interviews with …

Biochemical Characterization Of Small Molecule Inhibitor Binding On A Ras Related Gtpase And Its Effector Interactions, Djamali Muhoza

Graduate Theses and Dissertations

The Ras superfamily of GTPases has 167 proteins that are involved in various cellular processes such as proliferation, transformation, migration, and inhibition of cell death. Mutations, abnormal expression, and function of these proteins are observed in many diseases, including several forms of cancer. Even though these GTPases were among the first discovered oncogenes, no successful Ras drug candidate has successfully passed clinical trials. Drugs targeting these proteins have failed mainly because of the complexity of their regulation, their high affinity to GTP, and their structure’s dynamic nature. Recently, novel promising targeting approaches have renewed interest in the Ras drug discovery …

Molecular And Genetic Studies Of Robo2 Transcriptional Regulation In The Central Nervous System Of Drosophila Melanogaster, Muna Abdal Rahim Abdal Rhida

Graduate Theses and Dissertations

Drosophila Robo2 axon guidance receptor is a member of the evolutionarily conserved Roundabout (Robo) protein family that is involved in directing axons that cross the midline to the other side of the animal body. Robo2 roles mainly depend on two factors: The functional domains of the Robo2 protein, which is extensively studied, and the dynamic transcription of robo2 in various subsets of cells throughout embryogenesis which is not fully understood. Thus, knowing robo2 enhancers that transcriptionally regulate robo2 during embryogenesis is significant. To investigate robo2 potential enhancers, we screened 17 transgenic lines of Drosophila that were generated by Janelia Research …

Distress Tolerance As A Potential Target For Change: The Relationship Between Distress Tolerance, Craving, And Alcohol Consumption In A Lab-Based Experiment, Isabel F. Augur

Graduate Theses and Dissertations

Distress tolerance (DT) has recently been studied as a potential catalyst for the development ofalcohol use disorder (AUD). Research exploring the relationship between DT and craving is limited and has primarily focused on nicotine craving. Furthermore, there are no current studies examining the relationship between DT and alcohol consumption. This study was designed to fill this gap in the literature, which may shed light on a potentially important target for alcohol use treatment. Additionally, the role of mindfulness was explored in the context of the relationship between DT and alcohol craving and consumption, with the intention of expanding on the …

Development Of Biomaterials For Drug Delivery, Raquel De Castro

Graduate Theses and Dissertations

Drug delivery systems (DDS) have highly evolved in the last decades with the development of hydrogels and nanoparticles. However, high systemic uptake, side effects, low bioavailability, and encapsulation efficiency continue to be a major hurdle faced by such DDSs.

Nanoparticles and hydrogels can be specifically designed for targeted DDSs to mitigate some of the problems. This dissertation aimed to design two DDSs for ocular drug delivery and one for cancer treatment. The first project sought to develop chitosan nanoparticles (Cs-NP) using PEGDA as a copolymer to encapsulate gentamicin (GtS) for ocular drug delivery. Cs-NPs contain positive charges that can interact …