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Full-Text Articles in Medicine and Health Sciences
Exploring The Influence Of Psychosocial Stress And Inflammatory Properties Of The Diet On Cardiometabolic Risk And Gut Microbiome Health Among Young Adult Women Of Birmingham, Alabama, Rachel Olivia Knight
Exploring The Influence Of Psychosocial Stress And Inflammatory Properties Of The Diet On Cardiometabolic Risk And Gut Microbiome Health Among Young Adult Women Of Birmingham, Alabama, Rachel Olivia Knight
All ETDs from UAB
Concerning trends for obesity, diabetes, heart attacks, and obesity-related cancers, or cardiometabolic disease (CMD), are developing within the emerging and young adult/adulthood (EYA) population. Evidence supports the concept that chronic stress leads to physiologic dysregulation, reduced mental health, chronic diseases, and reduced longevity; however, these are not inevitable outcomes, and resilience or vulnerability is determined by interacting environmental and biobehavioral factors. Although CMD manifests clinically in older adulthood, disease pathophysiology begins earlier, and thus, EYA is a critical time for observation and intervention. Growing evidence indicates inflammation is a major risk factor in CMD development and may be exacerbated by …
Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer
Integrated Phenotypic And Molecular Expression Circuits In End-Stage Osteoarthritis, Devin J. Drummer
All ETDs from UAB
Osteoarthritis (OA) is a debilitating, inflammatory, joint degeneration disorder, and is the most common form of arthritis. Individuals reaching end-stage OA often pursue elective total hip/knee arthroplasty (THA/TKA) to relieve pain and improve mobility and quality of life. However, approximately one third of THA/TKA patients suffer long-term mobility impairments following surgery, likely in part due to an inability to repair the damaged muscle surrounding the diseased joint. Mechanisms driving this impaired recovery remain poorly understood, therefore it is prudent to interrogate the molecular signatures in skeletal muscle at the time of surgery to provide candidate markers that may improve upon …
Early Life Stress And Barrier Dysfunction Of The Blood-Brain Barrier, Margaret Ellen Lloyd
Early Life Stress And Barrier Dysfunction Of The Blood-Brain Barrier, Margaret Ellen Lloyd
All ETDs from UAB
Early Life Stress (ELS) refers to any process or event of chronic and/or sever stress that occurs early in an individual’s development; this can be spurred by environmental or behavioral cues and helps predict inflammation later1 in life. ELS is associated with increased risk of cardiovascular disease (CVD) and other chronic conditions like depression. However, many of the physiological processes that lead to increased risk of chronic illness later in life have yet to be established or examined. The ELS mouse model is used to examine the unknown mechanistic links between childhood stress and risk for chronic disease in adulthood. …