Open Access. Powered by Scholars. Published by Universities.®
- Discipline
- Keyword
-
- Doctor of Philosophy (PhD) Heersink School of Medicine (51)
- Doctor of Philosophy (PhD) School of Health Professions (9)
- Executive Doctor of Science (DSc) School of Health Professions (8)
- Doctor of Philosophy (PhD) School of Public Health (7)
- Doctor of Philosophy (PhD) School of Nursing (6)
-
- African American (5)
- Master of Dentistry (MDent) School of Dentistry (4)
- Master of Science in Dentistry (MScD) School of Dentistry (4)
- Aging (3)
- Caucasian (3)
- Depression (3)
- Doctor of Philosophy (PhD) School of Optometry (3)
- Doctor of Public Health (DrPH) School of Public Health (3)
- Master of Science (MS) School of Dentistry (3)
- Abutment (2)
- African Americans (2)
- Breast cancer (2)
- Cancer (2)
- Cardiovascular disease (2)
- Epigenetics (2)
- Exercise (2)
- Financial Performance (2)
- Glycosyltransferase (2)
- HIV (2)
- Hippocampus (2)
- Hospice (2)
- Hospital (2)
- Inflammation (2)
- LRRK2 (2)
- Metabolism (2)
Articles 1 - 30 of 102
Full-Text Articles in Medicine and Health Sciences
Admixture Mapping Of Subclinical And Clinical Cardiovascular Disease Among African Americans, Aditi Shendre
Admixture Mapping Of Subclinical And Clinical Cardiovascular Disease Among African Americans, Aditi Shendre
All ETDs from UAB
The purpose of this dissertation is to evaluate the association of local European ancestry (LEA) with subclinical and clinical cardiovascular (CV) disease (CVD) among African Americans in three prospective cohorts from the United States. CVD burden is higher among African Americans compared to other racial/ethnic groups and prevention efforts have led to the evaluation of subclinical measures of CVD such as carotid artery intima-media thickness (CIMT), and risk factors including the underlying genetic component of the disease. Admixed populations such as African Americans may have increased risk of disease as a result of the increased prevalence of a disease among …
Cell-Specific Pgc-1Α-Dependent Transcription: Implications For Cognitive And Motor Dysfunction, Laura Mcmeekin
Cell-Specific Pgc-1Α-Dependent Transcription: Implications For Cognitive And Motor Dysfunction, Laura Mcmeekin
All ETDs from UAB
Expression and/or function of transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is reduced in a variety of both neurodegenerative and psychiatric disorders. However, it is difficult to determine the significance of decreased PGC-1α expression and/or function in disease without knowing 1) the localization of these changes, 2) what the normal function of PGC-1α is in that specific cell-type, and 3) how its role in one neuronal population is different from its role in another. PGC-1α is highly expressed in GABAergic interneurons, and although it plays a significant role in interneuron function, several reports suggest that it also plays …
Analysis Of The Ciliary Genes Gas8 And Mks6 Reveal Conserved Roles In Cilia Motility And Transition Zone Function, Wesley Robert Lewis
Analysis Of The Ciliary Genes Gas8 And Mks6 Reveal Conserved Roles In Cilia Motility And Transition Zone Function, Wesley Robert Lewis
All ETDs from UAB
Cilia are microtubule based cellular appendages that are present throughout the hierarchy of the animal kingdom. These appendages are utilized for a wide array of functions such as motility in single celled organisms to coordinating complex cellular signaling pathways in more complex organisms. Though these appendages are well conserved, the exact function of cilia in many cell types remains unknown. Recently, cilia are tied to a myriad of developmental diseases and diseases of adult homeostasis collectively referred to as ciliopathies. Dysfunction in cilia results in a wide array of phenotypes ranging from retinal degeneration to polydactyly, cystic kidney disease, and …
Targeting The Tumor-Promoting Microenvironment With Inhibitors Of Pro-Hgf Activation, Benjamin Yaw Owusu
Targeting The Tumor-Promoting Microenvironment With Inhibitors Of Pro-Hgf Activation, Benjamin Yaw Owusu
All ETDs from UAB
The tumor microenvironment plays a key role in tumor progression and therapeutic resistance. Hepatocyte growth factor (HGF), commonly expressed by cancer-associated fibroblasts, mediates signaling via its receptor, MET, and promotes survival, proliferation, migration and invasion of cancer cells. In addition, HGF dependence has emerged as a hallmark of therapeutic resistance. HGF is secreted as an inactive precursor, pro-HGF, which requires proteolytic cleavage and processing to form the mature, active HGF. This is the rate-limiting step in the HGF/MET signaling pathway and it is achieved by one of the serine proteases, matriptase, hepsin and HGF activator (HGFA). At Southern Research, we …
Administrative Challenges In Pediatric Long-Term Care, Holly Elaine Jarek
Administrative Challenges In Pediatric Long-Term Care, Holly Elaine Jarek
All ETDs from UAB
ABSTRACT This research used a Delphi methodology to solicit challenges that significantly impact the operational success of pediatric long-term care facilities. Further, this study sought to understand the ability of pediatrics administrators to impact, affect, overcome, or resolve these challenges. Round 1 accomplished the desired goal of eliciting a substantial amount of new qualitative information regarding administrative challenges in pediatric long-term care, which previously had been extant in the literature. In Round 2, data were distilled into categories and unique exemplars which in turn were validated by participants. In Round 3, administrators ranked and rated categories and individual challenges in …
Cd4 Regulatory T Cells Augment Hiv-1 Expression Of Polarized M1 And M2 Monocyte Derived Macrophages, Tanya Robinson
Cd4 Regulatory T Cells Augment Hiv-1 Expression Of Polarized M1 And M2 Monocyte Derived Macrophages, Tanya Robinson
All ETDs from UAB
Polarization of macrophages is critical for an effective host immune response against invading pathogens. However, the HIV-1 virus can alter the cytokine/chemokine profile of polarized macrophages which may ultimately lead to their increased susceptibility to viral infection. M1 monocyte-derived macrophages (MDM) have been shown to suppress CCR5-tropic HIV-1 replication, while M2 MDM promote it. We generated M1 (GM-CSF + IFN-γ + LPS) and M2 (M-CSF + IL-4) MDM with predicted phenotypes and exposed them to a CCR5 (R5) “highly macrophage-tropic” viral strain, HIV-1BaL. M2 MDM had notably higher levels of HIV-1 infection than M1 MDM. We also investigated R5 HIV-1 …
A Study Of The Relationship Between Nasion Perpendicular And The True Vertical Line, Jeffrey Shelley
A Study Of The Relationship Between Nasion Perpendicular And The True Vertical Line, Jeffrey Shelley
All ETDs from UAB
A STUDY OF THE RELATIONSHIP BETWEEN NASION PERPENDICULAR AND THE TRUE VERTICAL LINE JEFFREY ALBERT SHELLEY JR. DEPARTMENT OF ORTHODONTICS ABSTRACT The purpose of this study is to assess the relationship between Nasion perpendicular and the true vertical line between patient groups using cephalometric analysis. Materials and Methods: Ninety-six adolescent patients comprised the sample for this study. Subjects were between 10 and 18 years old, with no major craniofacial deformity. Three groups of patients were divided in to three groups (Class I, Class II and Class III) based on their skeletal antero-posterior relationship. Pre-treatment lateral cephalometric radiographs were taken with …
The Function Of Prmt1 In Normal And Abnormal Megakaryopoiesis, Hairui Su
The Function Of Prmt1 In Normal And Abnormal Megakaryopoiesis, Hairui Su
All ETDs from UAB
Protein arginine methylation is a common type of post-translational modifications. Protein arginine methyltransferase 1 (PRMT1) is the predominant PRMT that is involved in diverse physiological and pathological processes in mammalian cells. Dysregulation of PRMT1 is often positively correlated with cancer development, yet many aspects of PRMT1’s role in cancer, especially in acute megakaryoblastic leukemia (AMKL) remain unclear. We identified two PRMT1-methylated substrates and how they impact normal and abnormal megakaryopoiesis. In this dissertation, we demonstrate that dual-specificity protein phosphatase 4 (DUSP4) and RNA binding motif protein 15 (RBM15), two crucial factors for megakaryocytic (MK) differentiation, are methylated by PRMT1 and …
Microglia Orchestrate The Inflammatory Response To Alpha-Synuclein In Parkinson Disease Models, Aaron Thome
Microglia Orchestrate The Inflammatory Response To Alpha-Synuclein In Parkinson Disease Models, Aaron Thome
All ETDs from UAB
Parkinson disease (PD) is the most common neurodegenerative movement disorder characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and widespread aggregates of the protein alpha-synuclein (α-syn). Increasing evidence points to inflammation as a chief mediator of PD with many of the inflammatory manifestations of human PD cases recapitulated in animal models of PD. We began by examining the inflammatory potential of α-syn fibrils, a newly characterized α-syn conformation that is neurotoxic and prion-like in its endogenous α-syn recruitment and cellular transmission. Our studies provide evidence that the α-syn fibrils evoke a pro-inflammatory response …
Polycomb Repressive Complex 2 And Heterochromatin Protein 1 Beta Regulate Neural And Neural Crest Development, Chih-Liang Tien
Polycomb Repressive Complex 2 And Heterochromatin Protein 1 Beta Regulate Neural And Neural Crest Development, Chih-Liang Tien
All ETDs from UAB
Epigenetic factors control gene expression via modulating chromatin conformation. Current studies on epigenetics mainly focus on biochemical mechanisms or functions of epigenetic factors in cancer or neurobiology. The underlying mechanism for epigenetic regulation in early embryonic development, particularly neural and neural crest development, is not well understood. In this thesis, the model organism, Xenopus laevis, is used to study epigenetic factors – polycomb repressive complex 2 (PRC2) and heterochromatin protein 1 beta (HP1β) in neural and neural crest development. In chapter one, the processes of neural and neural crest development are described, and the concepts of epigenetic mechanisms, such as …
Interplay Between Her2, Parp1, And Nf-Κb In Breast Cancer: Potential Therapeutic Implications, Monicka Ewa Wielgos
Interplay Between Her2, Parp1, And Nf-Κb In Breast Cancer: Potential Therapeutic Implications, Monicka Ewa Wielgos
All ETDs from UAB
We previously reported that HER2+ breast cancers are susceptible to Poly (ADP-Ribose) polymerase inhibitors (PARPi) alone, agents that are efficacious against homologous recombination (HR) deficient tumors. However, this phenomenon was determined to be independent of a HR repair deficiency but rather due to suppression of NF-κB activity and signaling by PARP inhibition. Further, HER2 overexpression itself was necessary and sufficient to confer this susceptibility. Interestingly, PARP1 and phosphorylated RelA/p65 (NF-κB) levels were found to be elevated in human HER2+ breast cancers compared to luminal breast cancers. These data suggest a possible interplay between HER2, PARP1, and NF-κB, and how this …
Development Of A Split Luciferase Complementation Assay To Investigate Growth Hormone Receptor/ Prolactin Receptor Homo-/ Hetero-Association, Ying Liu
All ETDs from UAB
Growth hormone receptor (GHR) and prolactin receptor (PRLR) are transmembrane glycoproteins cytokine receptors that are structurally homologous. Each can pre-homodimerize and ligand binding of each activates JAK2-STAT signaling pathways by inducing conformational change within the receptor homodimer. Human GHR can be activated by growth hormone (GH) while human PRLR can be activated by both GH and prolactin (PRL). We devised a split luciferase complementation assay, in which one receptor is fused to the N-terminal fragment of luciferase and the other receptor is fused to the C-terminal fragment of luciferase. When the two receptors approximate, luciferase activity (complementation) results. Using this …
Histopathology And Image Validation Of Outer Retinal Tubulations In Age-Related Macular Degeneration, Katie M. Litts
Histopathology And Image Validation Of Outer Retinal Tubulations In Age-Related Macular Degeneration, Katie M. Litts
All ETDs from UAB
High-resolution imaging of the retina using spectral domain optical coherence tomography (SD-OCT) and adaptive optics scanning laser ophthalmoscopy (AOSLO) is revealing new information about photoreceptor degeneration in age-related macular degeneration (AMD) and other diseases impacting rod and cone photoreceptors. By SD-OCT, the hyperreflective outer retinal bands are visible due to the precise vertical compartmentalization and horizontal alignment of outer retinal cells and tissues (Müller cells, photoreceptors, RPE, and Bruch’s membrane). Validating these bands with normal eyes is difficult because the outer retina is very delicate making accurate histology requiring attached retina and vertically aligned photoreceptors challenging. Conversely, the bands are …
Conjunctival Gene Expression And Tear Biomarkers In Atopic And Non-Atopic Keratoconus Patients Relative To Matching Controls, Erika Marie Morrow
Conjunctival Gene Expression And Tear Biomarkers In Atopic And Non-Atopic Keratoconus Patients Relative To Matching Controls, Erika Marie Morrow
All ETDs from UAB
Purpose: The aim of this study was to adapt conjunctival impression cytology (CIC) and RNA isolation to genetic analysis of the conjunctival surface of keratoconus (KC) patients with (AKC) and without atopic disease (AD) and with normal contact lens wearers (NCL). If RNA quantity and quality was sufficient, full transcriptome analysis would be conducted using RNA-Seq, rather than the more limited microarray approach. Methods: CIC samples were the ocular surface of 30 participants from four groups: 1) KC, 2) AKC, 3) AD, and 4) NCL. Several extraction and purification methods were investigated, including density gradient centrifugation, precipitation, conventional pelleting, and …
Examining The Impact Of Emergency Department (Ed) Registered Nurse (Rn) Staffing On Ed Patient Experience, Deana L. Nelson
Examining The Impact Of Emergency Department (Ed) Registered Nurse (Rn) Staffing On Ed Patient Experience, Deana L. Nelson
All ETDs from UAB
EXAMINING THE IMPACT OF EMERGENCY DEPARTMENT (ED) REGISTERED NURSE (RN) STAFFING ON ED PATIENT EXPERIENCE DEANA NELSON DOCTOR OF SCIENCE IN HEALTH SERVICES ADMINISTRATION ABSTRACT Patient experience ratings are important to healthcare organizations from both a clinical and financial perspective. Studies examining the relationship between patient experience and nurse staffing are prevalent in the inpatient setting, but not as much is known about how staffing affects these ratings in the Emergency Department (ED). This study examined the relationships between ED RN staffing, patient expectations and patient experience ratings, using a conceptual framework adapted from Donabedian’s structure/process/outcome model, and expectancy disconfirmation …
Novel Biomarkers For Parkinson Disease, Kyle Bradley Fraser
Novel Biomarkers For Parkinson Disease, Kyle Bradley Fraser
All ETDs from UAB
Parkinson disease (PD) is the most common neurodegenerative movement disorder for which no treatments exist capable of slowing progression of the disease. One obstacle slowing the development of novel therapies is the lack of molecular biomarkers for PD prognosis, tracking of disease progression, and assessing efficacious target engagement of compounds that do reach clinical trials. Missense mutations in LRRK2 account for between 1-5% of late onset PD and lead to increases in LRRK2 kinase activity and LRRK2 autophosphorylation. This thesis characterizes the secretion of LRRK2 into extracellularly secreted microvesicles called exosomes. We find that kinase-active LRRK2 is secreted within exosomes …
The Relationships Between Patient Satisfaction, Market Share, And Hospital Financial Performance, David W. Au
The Relationships Between Patient Satisfaction, Market Share, And Hospital Financial Performance, David W. Au
All ETDs from UAB
Quantitative scores enumerating patient experience with care have been introduced to healthcare via the Patient Protection and Affordable Care Act of 2010. Consumers can now compare with relative ease, different healthcare providers on the basis of standardized metrics. As government mandated transparency initiatives become commonplace as a result of the law, hospitals are more cognizant of how patient experience with care (operationalized using Hospital Consumer Assessment of Healthcare Providers and Systems: HCAHPS) has an impact on where patients decide to seek treatment. The proliferation of technological tools now enables patients to make meaningful quality and cost comparisons across providers. HCAHPS …
Regulation Of Vibrio Cholerae Biofilm Formation By H-Ns Repression And Anti-Repression, Julio Cesar Ayala-Figueredo
Regulation Of Vibrio Cholerae Biofilm Formation By H-Ns Repression And Anti-Repression, Julio Cesar Ayala-Figueredo
All ETDs from UAB
The diarrheal disease cholera is caused by the Gram-negative and motile bacterium Vibrio cholerae of serogroups O1 and O139. V. cholerae can switch between planktonic (motile) and sessile (biofilm) lifestyles. Biofilms are sessile communities encased in a self-produced extracellular matrix mainly composed of exopolysaccharide, proteins and extracellular DNA. Biofilm formation enhances the capacity of V. cholerae to persist in environmental waters and increases its infectivity. The bacterial second messenger cyclic diguanylic acid (c-di-GMP) regulates the transition between motile and biofilm lifestyles in V. cholerae. At low cell density, two c-di-GMP receptors, the LuxR-type regulator VpsT and the NtrC-type regulator VpsR …
Methods For Measuring Individually Experienced Temperature And Food Intake In Controlled Thermal Environments, Molly Bernhard
Methods For Measuring Individually Experienced Temperature And Food Intake In Controlled Thermal Environments, Molly Bernhard
All ETDs from UAB
The three studies to be presented assess individual-level heat exposure in free-living urban and rural environments and assess food intake in randomized controlled trials in a 2-hour exposure, and a 7-hour crossover heat exposure. The first interest was broad: examining heat exposure and its relation to potential health outcomes. To examine whether heat exposure could be measured in free-living organisms, a light and temperature monitoring device was repurposed and used in a pilot study of individual-level heat exposure in urban and rural community members. Differences between the current and most commonly accepted way of estimating heat exposure, weather station datasets, …
Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt
Structure-Function Relationships In The Sec7 Guanine Nucleotide Exchange Factor Gbf1, Jay Manoj Bhatt
All ETDs from UAB
All eukaryotic cells contain a secretory pathway composed of membrane-bound compartments connected by vesicles that transport cargo from the endoplasmic reticulum (ER) through the Golgi apparatus to various destination within and outside the cell. The Golgi Brefeldin A-resistant Factor 1 (GBF1) is required for protein traffic between ER and Golgi and within the Golgi. GBF1 belongs to a family of Guanine nucleotide Exchange Factors (GEFs) that stimulate the nucleotide exchange of GDP for GTP on small GTPases called ADP-ribosylation factors (ARFs). Once GTP-bound, ARFs become active and initiate a cascade of events that lead to vesicle formation. Thus, GBF1 is …
Leukemia Stem Cell Markers And Inv(16) In Acute Myeloid Leukemia, Jason Legrand
Leukemia Stem Cell Markers And Inv(16) In Acute Myeloid Leukemia, Jason Legrand
All ETDs from UAB
Although greater than 85% of inv(16) acute myeloid leukemia patients are able to achieve first complete remission after anthracycline- and cytarabine-based therapy, only about 60% of patients survive the disease long-term due to relapsed disease or treatment-related mortality. Multiple studies have shown that acute myeloid leukemia is composed of heterogeneous populations of leukemic clones that can exhibit a wide degree of genetic, epigenetic, and functional diversity, accounting for different outcomes in response to therapy. Genomic analysis of leukemic clones in paired diagnostic and relapse samples of acute myeloid leukemia has shown that all relapses stem from surviving leukemic or ancestral …
Malaria, Changes In Angiogenesis Factors, Cytokine Profiles And Birth Outcomes, John A. Keenan
Malaria, Changes In Angiogenesis Factors, Cytokine Profiles And Birth Outcomes, John A. Keenan
All ETDs from UAB
Malaria remains an important public health problem, with over three billion people at risk of infection and as many as 214 million new cases each year. Of particular concern is the effect Plasmodium falciparum malaria has on reproductive health. Malaria is responsible for a wide array of adverse birth outcomes including infant death, low birth weight, preterm delivery and small for gestational age. The mechanism by which malaria influences adverse birth outcomes remains poorly understood. Cross-sectional data from 291 women delivering infants in Ghana are used to investigate whether malaria during pregnancy was associated with select cytokines or angiogenesis factors …
The Matricellular Protein Ccn1 Potentiates Fibrogenic Responses To Lung Injury, Ashish Kurundkar
The Matricellular Protein Ccn1 Potentiates Fibrogenic Responses To Lung Injury, Ashish Kurundkar
All ETDs from UAB
Normal wound healing is a well-coordinated reparative response to injury aimed at restoring the normal tissue function. The dynamic interactions between cells and ex-tracellular matrix (ECM) regulate and dictate the fate of tissue repair process. Fibrosis is a dysregulated wound healing with excessive deposition of ECM and loss of tissue func-tion. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic disease of lung with no cure. Matricellular proteins are non-structural matrix proteins which regulates the cellular functions by directly binding to cell surface integrins and/or indirectly modulating growth factor signaling. Matricellular proteins are emerging as critical mediators of tissue injury …
Early-Life Programming Of Emotional Behaviors And Cardiovascular Function, Samir Rana
Early-Life Programming Of Emotional Behaviors And Cardiovascular Function, Samir Rana
All ETDs from UAB
Extensive evidence implicates bi-directional relationship between mood disorders and cardiovascular disorders. Early-life experience can have strong effects both on emotional development and cardiovascular function throughout life. Studies in humans are limited to correlational analyses, which are necessarily limited in terms of revealing mechanistic underpinnings of these associations. Thus, various pre-clinical models are utilized to investigate the effects of early-life experience in various domains, such as behavior and cardiovascular function, which are likely mediated by epigenetic mechanisms. Previous studies have used maternal separation and neonatal handling in developing rodents as a way to model differences in early-life experience. The effect of …
Hiv-1 Adaptation To T-Cell Responses During Infection, Victor Yimin Du
Hiv-1 Adaptation To T-Cell Responses During Infection, Victor Yimin Du
All ETDs from UAB
It is well known that CD8 T cells play an important role in viral control. Many viruses, including human immunodeficiency virus-1 (HIV-1), escape from CD8 T-cell mediated immune pressure. Increasing number of studies have suggested that CD4 T cells, usually considered as primary targets of HIV-1 infection, can also play an active antiviral role and hence can drive viral escape like their CD8 counterparts. The works presented in this dissertation examined the impact of transmitted HIV-1 escapes on CD8 T-cell responses and clinical outcomes following infection, the ability of CD8 T cells to cross-recognize viral variants during acute infection, and …
Motor Unit Remodeling During Neuromuscular Degeneration In Aging And Parkinson's Disease, Neil Anthony Kelly
Motor Unit Remodeling During Neuromuscular Degeneration In Aging And Parkinson's Disease, Neil Anthony Kelly
All ETDs from UAB
The human neuromuscular system deteriorates progressively with age and disease. This results in denervation events and ultimately motor unit remodeling, which is revealed by abnormal “groups” of myofibers expressing the same myosin protein isoform – a phenomenon described as myofiber type grouping. Despite the acceptance of myofiber type grouping as a hallmark indicator of motor unit remodeling, traditional techniques of detecting it lack quantitative parameters and therefore comparative data in aging and disease are scarce. The purpose of this dissertation is to establish a statistically-driven, quantitative method for detecting myofiber type grouping and to use it to characterize the effects …
Correlating High Reliability Organization Practices With Preventable Harms Across Children’S Hospitals Participating In The Children’S Hospitals’ Solutions For Patient Safety Collaborative, Kelly H. Randall
All ETDs from UAB
Background: Despite significant effort, focus, and resources dedicated to reducing patient safety risk, the healthcare system continues to have high error rates. Approaches and strategies implemented to decrease human error have been marginally successful in achieving sustainable reduction in patient harm. Purpose: The purpose of this study was to examine the association between high reliability and patient safety outcomes by testing the following hypotheses: Organizations exhibiting more advanced high reliability practice will have fewer hospital acquired conditions (as defined by the Serious Harm Event Index (SHE) than organizations exhibiting less advanced high reliability practices; and organizations exhibiting more advanced high …
Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell
Exploring Bacteriophage P22 As A Selective Molecular Scaffold And Molecular Sensor, Gregory Joseph Bedwell
All ETDs from UAB
The virus capsids of many dsDNA bacteriophage are finely tuned macromolecular machines. Their functionality begins at assembly, when their capsids are built under the guidance of a class of proteins referred to as scaffolding proteins. The scaffolding protein of bacteriophage P22 is a flexible, highly elongated protein that binds to the interior surface of the P22 procapsid via its C-terminal domain. The finding that N-terminus is dispensable for procapsid binding prompted the development of chimeric scaffolding protein molecules, wherein N-terminal residues of scaffold are replaced with a variety of different peptide sequences or functional proteins that are then encapsidated within …
Glycosyltransferases Involved In The Glycosylation Of Serine-Rich Glycoproteins From Streptococci, Fan Zhu
Glycosyltransferases Involved In The Glycosylation Of Serine-Rich Glycoproteins From Streptococci, Fan Zhu
All ETDs from UAB
Serine - rich repeat glycoproteins (SRRPs) play important roles in mediating bac-terial attachment to a variety of host and microbial surfaces. They have been im-plicated in the development of tissue infections such as pneumonia, infective en-docarditis, meningitis and oral infectious diseases. Streptococcus parasanguinis, one of the commensal streptococci present in the oral cavity, utilizes its fimbriae to mediate the initial attachment to the tooth pellicle. Fap1 (Fimbriae-associated-protein 1), the first identified SRRP, is the subunit of the fimbriae which utilizes proteins encoded by an 11-gene cluster (gly-gtf3-dGT1-galT2 and secY2-gap1-gap2-gap3-secA2-gtf1-gtf2) to mediate its glycosylation and secretion. The key enzymes responsible for …
Capacity Of The 3m True Definition Scanner To Make Repeatable Impressions Depending On Placement Of Margins In Relation To Gingival Height., Ricardo Jose Galindo Ramirez
Capacity Of The 3m True Definition Scanner To Make Repeatable Impressions Depending On Placement Of Margins In Relation To Gingival Height., Ricardo Jose Galindo Ramirez
All ETDs from UAB
Purpose: To determine the precision and accuracy of the True Definition Scanner (3M) (TDS) to capture margins at different gingival heights. Materials and Methods: A typodont with soft gingiva and removable indexed Ivorine® teeth was used. Tooth #19 was prepared to fit an all-ceramic crown with a chamfer margin. Spacers placed beneath the prepared tooth elevated #19 in the typodont and controlled the tooth margin height relative to the gingival margin. The TDS was used as an intraoral scanner. A total of 50 scans were made with 5 groups of 10 scans each. In Group 1 (control) the prepared tooth …