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2017 Summer Research Symposium Abstract Book, Trinity College, Hartford Connecticut

Science Symposia Abstracts

2017 Summer volume of abstracts for science research projects conducted by students at Trinity College.

Editorial: Metabolic Control Of Brain Homeostasis, Detlev Boison, Jochen C. Meier, Susan A. Masino

Faculty Scholarship

No abstract provided.

2017 Annual Research Symposium Abstract Book, Trinity College, Hartford Connecticut

Science Symposia Abstracts

2017 annual volume of abstracts for science research projects conducted by students at Trinity College.

Heavy Drinking In College Students Is Associated With Accelerated Gray Matter Volumetric Decline Over A 2 Year Period, Shashwath A. Meda, Alecia D. Dager, Keith A. Hawkins, Howard Tennen, Sarah Raskin, Rebecca Wood, Carol S. Austad, Carolyn Fallahi, Godfrey D. Pearlson

Faculty Scholarship

Background: Heavy and/or harmful alcohol use while in college is a perennial and significant public health issue. Despite the plethora of cross-sectional research suggesting deleterious effects of alcohol on the brain, there is a lack of literature investigating the longitudinal effects of alcohol consumption on the adolescent brain. We aim to probe the longitudinal effects of college drinking on gray matter change in students during this crucial neurodevelopmental period.

Methods: Data were derived from the longitudinal Brain and Alcohol Research in College Students (BARCS) study of whom a subset underwent brain MRI scans at two time points 24 months apart. …

Undocumented: The Health Effects Of Latino Youth In The United States, Elizabeth Patino

The Trinity Papers (2011 - present)

No abstract provided.

Longitudinal Influence Of Alcohol And Marijuana Use On Academic Performance In College Students, Shashwath A. Meda, Ralitza V. Gueorguieva, Brian Pittman, Rivkah R. Rosen, Farah Aslanzadeh, Howard Tennen, Samantha Leen, Keith A. Hawkins, Sarah Raskin, Rebecca Wood, Carol S. Austad, Alecia Dager, Carolyn Fallahi, Godfrey D. Pearlson

Faculty Scholarship

Background

Alcohol and marijuana are the two most abused substances in US colleges. However, research on the combined influence (cross sectional or longitudinal) of these substances on academic performance is currently scant.

Methods

Data were derived from the longitudinal 2-year Brain and Alcohol Research in College Students (BARCS) study including 1142 freshman students who completed monthly marijuana use and alcohol consumption surveys. Subjects were classified into data-driven groups based on their alcohol and marijuana consumption. A linear mixed-model (LMM) was employed using this grouping factor to predict grade point average (GPA), adjusted for a variety of socio-demographic and clinical factors. …

Metabolic Dysfunction Underlying Autism Spectrum Disorder And Potential Treatment Approaches, Ning Cheng, Jong M. Rho, Susan A. Masino

Faculty Scholarship

Autism spectrum disorder (ASD) is characterized by deficits in sociability and communication, and increased repetitive and/or restrictive behaviors. While the etio-pathogenesis of ASD is unknown, clinical manifestations are diverse and many possible genetic and environmental factors have been implicated. As such, it has been a great challenge to identify key neurobiological mechanisms and to develop effective treatments. Current therapies focus on co-morbid conditions (such as epileptic seizures and sleep disturbances) and there is no cure for the core symptoms. Recent studies have increasingly implicated mitochondrial dysfunction in ASD. The fact that mitochondria are an integral part of diverse cellular functions …

Ketogenic Diet Improves Behaviors In A Maternal Immune Activation Model Of Autism Spectrum Disorder, David N. Ruskin, Michelle I. Murphy, Sierra L. Slade, Susan A. Masino

Faculty Scholarship

Prenatal factors influence autism spectrum disorder (ASD) incidence in children and can increase ASD symptoms in offspring of animal models. These may include maternal immune activation (MIA) due to viral or bacterial infection during the first trimesters. Unfortunately, regardless of ASD etiology, existing drugs are poorly effective against core symptoms. For nearly a century a ketogenic diet (KD) has been used to treat seizures, and recent insights into mechanisms of ASD and a growing recognition that immune/inflammatory conditions exacerbate ASD risk has increased interest in KD as a treatment for ASD. Here we studied the effects of KD on core …