Medicine and Health Sciences Commons^™

Systemic Vasculitides. Part 2: Small Vessel Diseases, Sean M. Conte, Peter R. Vale

Medical Papers and Journal Articles

Small vessel vasculitides often manifest as neurological, renal, pulmonary and dermatological symptoms. Clinical features of systemic vasculitides are often nonspecific; therefore, it is important that GPs be aware of the range of symptoms that can help in the differential diagnosis, treatment and management of this diverse group of conditions.

The Challenge Of An Expanded Therapeutic Window In Pulmonary Hypertension, Simon Stewart, Geoffrey A. Strange, David Playford

Medical Papers and Journal Articles

Our understanding of the causes and consequences of pulmonary hypertension is limited. Consequently, its most distinctive forms with the worst prognosis have been the focus for diagnosis and treatment. We highlight the emerging challenge of reframing the prevalence and prognostic implications of pulmonary hypertension, focusing on the optimal therapeutic window to address the high mortality linked to this condition.

Familial Hypercholesterolaemia In 2020: A Leading Tier 1 Genomic Application, Jing Pang, David R. Sullivan, Tom Brett, Karam M. Kostner, David L. Hare, Gerald F. Watts

Medical Papers and Journal Articles

Familial hypercholesterolemia (FH) is caused by a major genetic defect in the low-density lipoprotein (LDL) clearance pathway. Characterised by LDL-cholesterol elevation from birth, FH confers a significant risk for premature coronary artery disease (CAD) if overlooked and untreated. With risk exposure beginning at birth, early detection and intervention is crucial for the prevention of CAD. Lowering LDL-cholesterol with lifestyle and statin therapy can reduce the risk of CAD. However, most individuals with FH will not reach guideline recommended LDL-cholesterol targets. FH has an estimated prevalence of approximately 1:250 in the community. Multiple strategies are required for screening, diagnosing and treating …

Managing Anxiety Disorders In Adults, Gregory Wilkins, Gavin Andrews, Caroline Bell, Philip Boyce, Christopher Gale, Ronald Rapee, Lisa Lampe

Medical Papers and Journal Articles

The GP has a key role in identifying patients presenting with anxiety symptoms and ensuring appropriate acute and long-term management. There are two key messages for GPs to follow: once you have made a diagnosis of an anxiety disorder, tell the patient you have a treatment for it. Second, do not let your anxiety lead you to prescribe inappropriately or overinvestigate for all possible differential diagnoses.

Diagnosing Pulmonary Hypertension Due To Left Heart Disease Using Diastolic Echo Markers: The National Echo Database Of Australia (Neda) Ph-Lhd Predictive Formula, Kevin Chung

Theses

Aims: Pulmonary hypertension (PH) is commonly due to left heart disease caused by ischaemic heart disease, hypertension and valvular heart disease. It is under diagnosed and associated with a high mortality. PH diagnosed using echo requires a measurable tricuspid regurgitation velocity (TRV) to estimate the pulmonary artery systolic pressure (PH = PASP >40mmHg). However, up to 40% of studies have insufficient TRV to calculate a PASP. This can lead to significant delays in the diagnosis of pulmonary hypertension, increased morbidity and delays in the initiation of treatment.

This thesis seeks to determine the prevalence of PH and the diastolic echo …

Detection And Management Of Familial Hypercholesterolaemia In Primary Care In Australia: Protocol For A Pragmatic Cluster Intervention Study With Pre-Post Intervention Comparisons, Diane Arnold-Reed, Tom Brett, Lakkhina Troeung, Alistair Vickery, Jacquie Garton-Smith, Damon Bell, Jing Pang, Tegan Grace, Caroline Bulsara, Iain Li, Max Bulsara, Gerald F. Watts

Medical Papers and Journal Articles

Introduction: Familial hypercholesterolaemia (FH), an autosomal dominant disorder of lipid metabolism, results in accelerated onset of atherosclerosis if left untreated. Lifelong treatment with diet, lifestyle modifications and statins enable a normal lifespan for most patients. Early diagnosis is critical. This protocol trials a primary care-based model of care (MoC) to improve detection and management of FH.

Methods and analysis: Pragmatic cluster intervention study with pre-post intervention comparisons in Australian general practices. At study baseline, current FH detection practice is assessed. Medical records over 2 years are electronically scanned using a data extraction tool (TARB-Ex) to identify patients at increased …

Optimising Motor Learning Of Infants At High Risk Of Cerebral Palsy Using Goal-Oriented And Environmental Interventions, Catherine Morgan

Theses

Background and aims: Cerebral palsy (CP) is the most common physical disability of childhood occurring in 1 in 500 live births in developed countries. Although CP starts in infancy because of a lesion in the developing brain, it is usually not diagnosed until about 19 months. The problem with late detection has meant that early neurorehabilitation is not accessed until motor impairment is evident. Consequently the dose of active intervention during the critical period for brain plasticity is often inadequate. Little evidence exists for the effectiveness of early intervention (EI) protocols for infants with CP. In particular, interventions that take …