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Plasmodial Hsp40s: New Avenues For Antimalarial Drug Discovery, M Daniyan, G Blatch
Plasmodial Hsp40s: New Avenues For Antimalarial Drug Discovery, M Daniyan, G Blatch
Medical Papers and Journal Articles
Malaria, an infectious disease caused by Plasmodium spp, is one of the world's most dangerous diseases, accounting for more than half a million deaths yearly. The long years of co-habitation between the parasite and its hosts (human and mosquito), is a testimony to the parasite’s ability to escape the immune system and develop drug resistance mechanisms. Currently, an important search area for improved pharmacotherapy are molecular chaperones of the heat shock protein family, abundant in Plasmodium falciparum and contributing to its continuous survival and development. Thus far, small molecule inhibitor studies on P. falciparum Hsp70s and Hsp90s have indicated that …