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Full-Text Articles in Medicine and Health Sciences
Αvβ8 Integrin Interacts With Rhogdi1 To Regulate Rac1 And Cdc42 Activation And Drive Glioblastoma Cell Invasion, Steve Reyes
Αvβ8 Integrin Interacts With Rhogdi1 To Regulate Rac1 And Cdc42 Activation And Drive Glioblastoma Cell Invasion, Steve Reyes
Dissertations & Theses (Open Access)
As an interface between the circulatory and central nervous systems, the neurovascular unit is vital to the development and survival of tumors. The malignant brain cancer glioblastoma multiforme (GBM) displays invasive growth behaviors that are major impediments to surgical resection and targeted therapies. Adhesion and signaling pathways that drive GBM cell invasion remain largely uncharacterized. Here we have utilized human GBM cell lines, primary patient samples, and pre-clinical mouse models to demonstrate that integrin αvβ8 is a major driver of GBM cell invasion. β8 integrin is overexpressed in many human GBM cells, with higher integrin expression correlating with increased invasion …
Cip4 And Src In Promoting The Migration And Invasion Of Breast Cancers, Christina S. Pichot
Cip4 And Src In Promoting The Migration And Invasion Of Breast Cancers, Christina S. Pichot
Dissertations & Theses (Open Access)
Cellular invasion represents a critical early step in the metastatic cascade, and many proteins have been identified as part of an “invasive signature.” The non-receptor tyrosine kinase Src is commonly upregulated in breast cancers, often in conjunction with overexpression of EGFR. Signaling from this pathway stimulates cell proliferation, migration, and invasion and frequently involves proteins that regulate the cytoskeleton. My data demonstrates that inhibition of Src, using the small-molecule inhibitor dasatinib, impairs cellular migration and invasion. Furthermore, Src inhibition sensitizes the cells to the effects of the chemotherapeutic doxorubicin resulting in dramatic, synergistic inhibition of proliferation with combination treatments. The …