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Medium From Irradiated Cells Induces A Dose Dependent Expression Of Mitochondrial Changes And Bcl2 Responses In Unirradiated Human Keratinocytes, Paula Maguire, Carmel Mothersill, C. Seymour, Fiona Lyng
Medium From Irradiated Cells Induces A Dose Dependent Expression Of Mitochondrial Changes And Bcl2 Responses In Unirradiated Human Keratinocytes, Paula Maguire, Carmel Mothersill, C. Seymour, Fiona Lyng
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Exposure of unirradiated human keratinocytes to irradiated cell conditioned medium (ICCM) is known to cause a cascade of events that leads to reproductive death and apoptosis. This study investigates the effect of ICCM on clonogenic survival, mitochondrial mass and BCL2 expression in unirradiated keratinocytes. Exposure to 5 mGy, 0.5 Gy and 5 Gy ICCM resulted in a significant decrease in clonogenic survival. Human keratinocytes incubated with ICCM containing an antioxidant, N-acetylcysteine, showed no significant decrease in clonogenic survival. HPV-G cells incubated with ICCM containing a caspase 9 inhibitor showed no significant decrease in clonogenic survival when the ICCM dose was …