Medicine and Health Sciences Commons^™

An Exploration Of The Causes And Effects Of Interpersonal Conflict Related Stress Among A Self-Selected Cohort Of Second Level Teachers In Ireland, Patrick Bruce

Theses

Teaching has been classified by researchers as a high stress profession. Stress in teaching has been reported to have many negative health outcomes and also affects productivity. The literature also reports that stress in teaching is a difficult matter to resolve satisfactorily, with mixed outcomes from interventions. An emergent cause of work-related stress in education is IPC and this study sets out to investigate the prevalence of this underreported phenomena.

A sample of 25 teachers working in Irish second level schools were recruited. Semi structured interviews were conducted to report on the experiences of stress, it’s causes and effects both …

Development Of Novel Anticancer Agents Targeting Glioblastoma, Kate Byrne

Theses

Glioblastoma (GBM) is the most common and aggressive malignant grade IV brain tumour. It remains an incurable disease whereby the median survival rate is 15 months and 5.5 % of all patients survive five years post diagnosis. The current therapeutic strategies include the use of maximal safe surgical resection, radiotherapy, and the use of the gold standard chemotherapeutic, Temozolomide (TMZ), which is referred to as the “Stupp Protocol”. Earlier research identified two compounds, which are structurally different but exhibit a similar biological effect to Metformin, the first in-line treatment for type II diabetes. Combining drugs which target cell metabolism such …

The Synthesis And Biological Assessment Of Novel Ursolic Acid Derivatives As Potential Chemotherapeutic Agents For Cancer, Julie Rose Mae Mondala

Theses

Glioblastoma (GBM) is considered to be the most biologically aggressive type of brain tumour accounting for approximately 48% of all malignant primary brain tumours. GBM patients diagnosed have poor prognosis with a low five-year survival rate of

The aim of this study was to develop novel UA derivatives to enhance its bioavailability. Nine novel UA derivatives: three different diamine linkers, with Boc-protected and deprotected ends, and with folic acid were designed and synthesized to improve compound activity and/or delivery. The structures of the newly synthesised compounds were confirmed using mass spectrometry, FTIR, 1H NMR and 13C NMR. The structural activity …