Medicine and Health Sciences Commons^™

Effects Of Acetaminophen, Etodolac And Indomethacin On Migration, Proliferation And Collagen Expression Of Tendon Cells, Yun-Ming Yang, Hsiang-Ning Chang, S Jong-Hwei Pang, Chung-Bao Hou, Wen-Chung Tsai

Rehabilitation Practice and Science

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to treat tendinopathy. Tendon healing requires migration of tendon cells to the repair site, followed by proliferation of these cells and collagen synthesis. Purpose: This study evaluated the effects of acetaminophen, etodolac, and indomethacin on tenocyte migration, proliferation, and synthesis of type I and III collagen. Methods: Rat Achilles tendon cells were treated with acetaminophen, etodolac, and indomethacin. Tendon cell migration and proliferation were assessed using transwell filter migration assay and MTT assay, respectively. The expression of collagen I and III mRNA were evaluated by quantitative real-time polymerase chain reaction. Results: Unlike …