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Full-Text Articles in Medicine and Health Sciences
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
The Effect Of 1,25-Dihydroxyvitamin D3 On Liver Damage, Oxidative Stress, And Advanced Glycation End Products In Experimental Nonalcoholicand Alcoholic- Fatty Liver Disease, İlknur Bi̇ngül, Abdurrahman Fati̇h Aydin, Canan Küçükgergi̇n, Asi̇ye Işin Doğan Eki̇ci̇, Semra Abbasoğlu, Mehmet Müjdat Uysal
Turkish Journal of Medical Sciences
Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)2 D3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)2 D3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats. Materials and methods: Rats were treated with fructose (30%) or ethanol (5-20%) in drinking water with and without 1,25(OH)2 D3 treatment (5 µg/kg two times a week) for 8 weeks. …
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Rho/Rho-Kinase Signalling In Chronically Alcohol-Fed Mice, Havva Kubat, Ahmet Sencer Yurtsever, Kansu Büyükafşar
Turkish Journal of Medical Sciences
Background/aim: The effects of chronic ethanol consumption on male sexual function are debateable, and its effects on the Rho/ Rho-kinase pathway are unknown. Therefore, we investigated smooth muscle reactivity and Rho/Rho-kinase signalling in the corpus cavernosum of ethanol-fed mice. Materials and methods: Ethanol was added to drinking water at 5% concentration in the first 2 days with 5% increment every subsequent 2 days, up to a final concentration of 20% for 45 days. Corpora cavernosa were isolated and a cumulative dose-response curve to phenylephrine was obtained. Acetylcholine (10-6 M), electrical field stimulation (EFS, 40 V, 8-16 Hz) and Y-27632 (10-6-10-5 …
Effects Of Some Of The Regional Turkish Fermented Foods And Medications On Respiratory Alcohol Levels, Cem Uysal, Mustafa Karapi̇rli̇, Mehmet Aki̇f İnanici
Effects Of Some Of The Regional Turkish Fermented Foods And Medications On Respiratory Alcohol Levels, Cem Uysal, Mustafa Karapi̇rli̇, Mehmet Aki̇f İnanici
Turkish Journal of Medical Sciences
Alcohols are used in many areas like medicine and industry. They may be naturally found in some fruits and vegetables secondary to fermentation. According to the traffic law in Turkey, professional drivers are prohibited from driving while they are under the influence of alcohol; nonprofessional drivers are allowed to drive vehicles with a blood alcohol level of up to 50 mg/dL. The aim of this research is to determine whether or not consumed medicine or fermented, nonalcoholic beverages cause false positive results in breathalyzer tests. Materials and methods: In this research, we used nonalcoholic fermented foods and 6 medicines. After …
Effect Of Oocyte Quality And Activation Protocols On Bovine Embryo Development Following Intracytoplasmic Sperm Injection, Ömer Korkmaz, Şükrü Küplülü, Yüksel Ağca, İbrahi̇m Mert Polat
Effect Of Oocyte Quality And Activation Protocols On Bovine Embryo Development Following Intracytoplasmic Sperm Injection, Ömer Korkmaz, Şükrü Küplülü, Yüksel Ağca, İbrahi̇m Mert Polat
Turkish Journal of Veterinary & Animal Sciences
The purpose of this study was to investigate the effects of oocyte quality and activation protocols on the in vitro developmental competence of bovine embryos after intracytoplasmic sperm injection (ICSI). Bovine oocytes were grouped as being of excellent, good, and poor quality. All of the oocytes were activated using a calcium ionophore only, ethanol only, and 6-dimethylaminopurine (6-DMAP) following calcium ionophore. For the excellent quality oocytes, cleavage rates after ICSI were 70% in the Ca ionophore + 6-DMAP activation group, 47% in the ethanol activation group, 41.82% in the Ca ionophore group, and 30% in the nontreated control group. Cleavage …
Contribution Of Phospholipase C And Protein Kinase C But Not Endothelin-Converting Enzyme To Contractile Responses Of Ethanol, Naci̇ye Döndaş, Hali̇l Mahi̇r Kaplan, Derya Kaya, Erği̇n Şi̇ngi̇ri̇k
Contribution Of Phospholipase C And Protein Kinase C But Not Endothelin-Converting Enzyme To Contractile Responses Of Ethanol, Naci̇ye Döndaş, Hali̇l Mahi̇r Kaplan, Derya Kaya, Erği̇n Şi̇ngi̇ri̇k
Turkish Journal of Medical Sciences
Aim: To evaluate the possible roles of phospholipase C, protein kinase C, and endothelin-converting enzyme on contractions induced by ethanol (164 mM) in isolated gastric fundal strips of mice. Materials and methods: After the mice were killed, the stomach of each was removed and longitudinal muscle strips were prepared from the gastric fundus. The strips were mounted in organ baths and their responses were recorded isometrically. Ethanol (164 mM) was added to the organ baths and a steady-state contraction was obtained. After the first ethanol response was recorded, the preparations were incubated separately with lidocaine (1-100 µM), neomycin (10-500 µM), …
Effect Of Pre-Evisceration, Skin-On Carcass Decontamination Sanitation Strategies For Reducing Bacterial Contamination Of Cattle During Skinning, Mehmet Çalicioğlu, Dennis R. Buege, John B. Luchansky
Effect Of Pre-Evisceration, Skin-On Carcass Decontamination Sanitation Strategies For Reducing Bacterial Contamination Of Cattle During Skinning, Mehmet Çalicioğlu, Dennis R. Buege, John B. Luchansky
Turkish Journal of Veterinary & Animal Sciences
The effectiveness of pre-evisceration, skin-on carcass sanitation on reducing bacterial contamination of beef carcasses was tested using 3 cattle per treatment and 3 cattle as controls at each of 3 abattoirs in southern Wisconsin. The sanitation procedure included stunning, bleeding, tying off the esophagus, sealing the anus, and then sanitizing the hide with: i) 20% trisodium phosphate, ii) 200 ppm iodophor, iii) 75% ethanol, or iv) hot water (ca. 80 °C). Two sets of combined sponge samples (3 × 100 cm^2) were taken from the hide before and after the sanitation step, as well as from the carcass after the …
The Treatment Of Experimental Acute Ethylene Glycol (Antifreeze) Toxication Using 4-Methyl Pyrazol And Ethanol In Dogs, Vehbi̇ Güneş, Çeti̇nkaya Şendi̇l
The Treatment Of Experimental Acute Ethylene Glycol (Antifreeze) Toxication Using 4-Methyl Pyrazol And Ethanol In Dogs, Vehbi̇ Güneş, Çeti̇nkaya Şendi̇l
Turkish Journal of Veterinary & Animal Sciences
The effects of ethanol and 4-methyl pyrazole were investigated in the treatment of 30 dogs toxicated with antifreeze (AF). The AF toxication produced significant increases in blood urea, creatinin and potassium and a decrease in blood calcium levels. Calcium-oxalate monohydrate, which is pathognomic for AF toxication, was consistently seen in urine sediment. Ethanol was rarely effective on the multisystemic effects that occurred in dogs or ADH inhibition. CNS findings were also observed after ethanol administration. The results indicated that 4-MP treatment provided earlier and safer healing than ethanol. It was deduced that 4-MP + NaHCO_3 was more effective than ethanol …
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Microscopy Of Rat Thoracic Aorta In Chronic Ethanol Intake, Feral Öztürk, Ni̇gar Vardi, Nureddi̇n Cengi̇z, Mukaddes Eşrefoğlu, Ali̇ Otlu
Turkish Journal of Medical Sciences
The aim of this study was to determine the histological changes of the thoracic aorta in rats fed on alcohol for a period of 24 weeks. Twenty male Wistar rats were divided into two groups. The ethanol group (n=10) was fed on a modified liquid diet (MLD) containing 7.2% ethanol for 24 weeks. The control group (n=10) was fed on MLD without ethanol throughout the experiment. At the end of the 24 weeks, the carotid arteries of the rats were cannulated and their blood pressures were measured. Ethanol levels measured by using the NAD+/NADH enzyme-spectrophotometric method. Rats were killed by …
The Effects Of Orally Ethanol Treatment On Serum, Liver And Kidney\Gamma-Gt, Alt And Ast Enzymes Activity And Serum Total Cholesterol And Lipid Levels In Rats, Ayla Özcan, Ahmet Mengi̇
The Effects Of Orally Ethanol Treatment On Serum, Liver And Kidney\Gamma-Gt, Alt And Ast Enzymes Activity And Serum Total Cholesterol And Lipid Levels In Rats, Ayla Özcan, Ahmet Mengi̇
Turkish Journal of Veterinary & Animal Sciences
In this study, some blood, liver and kidney parameters of rats which were given alcohol orally were investigated at the end of 1st, 7th, 14th and 21st days. Forty male Wistar Albino rats (mean 196 g), 20 wk of age, were used as materials. Serum AST and \gamma-GT activities at the end of 1st day were significantly different between control and experimental groups from 40 rats studied. At the end of 7th, 14th and 21st days, the difference between two groups for AST and \gamma-GT activities in serum and liver were significant (p