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The Role Of Il-6 And Osteoprotegerin In Bone Metabolism In Patients With Graves' Disease, Tülay Omma, Çi̇ğdem Yücel, Erdi̇m Sertoğlu, Sevde Nur Firat, Cavi̇t Çulha, Taner Özgürtaş
The Role Of Il-6 And Osteoprotegerin In Bone Metabolism In Patients With Graves' Disease, Tülay Omma, Çi̇ğdem Yücel, Erdi̇m Sertoğlu, Sevde Nur Firat, Cavi̇t Çulha, Taner Özgürtaş
Turkish Journal of Medical Sciences
Background/aim: Increased bone turnover is a hallmark of hyperthyroidism. The underlying factors of how thyroid hormones affect bone cells are still under the spotlight. Previous studies indicated serum osteoprotegerin (OPG), receptor activator of NF-kB ligand (RANKL), and interleukin-6 (IL-6) as mediators of the effect of thyroid hormones on bone metabolism. Ultimately, the present research aimed to examine the association of IL-6 with OPG and RANKL in patients with hyperthyroidism. Materials and methods: We carried out this study with 39 newly diagnosed and untreated Graves' patients and 43 healthy controls. In addition to routine tests, we measured serum OPG, RANKL, and …