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Full-Text Articles in Medicine and Health Sciences
Enos Gene Polymorphisms In Paraffin-Embedded Tissues Of Prostate Cancer Patients, Fi̇kri̇ye Polat, Nesri̇n Turaçlar, Meral Yilmaz, Günsel Bi̇ngöl, Hasi̇be Ci̇ngi̇lli̇ Vural
Enos Gene Polymorphisms In Paraffin-Embedded Tissues Of Prostate Cancer Patients, Fi̇kri̇ye Polat, Nesri̇n Turaçlar, Meral Yilmaz, Günsel Bi̇ngöl, Hasi̇be Ci̇ngi̇lli̇ Vural
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to investigate whether endothelial nitric oxide synthase (eNOS) gene polymorphisms play a role in prostate cancer (PCa). Materials and methods: We examined three eNOS gene polymorphisms (T-786C promoter region, G894T, and Intron 4 VNTR 4a/b) at extracted DNAs from 50 formalin-fixed paraffin-embedded tissues of PCa patients. For the controls, blood samples obtained from 50 healthy men were studied. Genotyping of molecular variants was performed by PCR-RFLP technique. Results: We found that the TC genotype of the T-786C polymorphism was associated with PCa risk (OR: 3.325, CI: 1.350-8.188, P = 0.008). The eNOS …
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH. Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = …
Polymorphism Of Exon 2 Of Dio2 Gene And Its Association Withseasonal Reproduction In Sheep, Jianning He, Dongwei Huang, Ran Di, Jinxin Wang, Mingxing Chu, Qiuyue Liu, Wenping Hu, Xiangyu Wang, Zhangyuan Pan
Polymorphism Of Exon 2 Of Dio2 Gene And Its Association Withseasonal Reproduction In Sheep, Jianning He, Dongwei Huang, Ran Di, Jinxin Wang, Mingxing Chu, Qiuyue Liu, Wenping Hu, Xiangyu Wang, Zhangyuan Pan
Turkish Journal of Veterinary & Animal Sciences
DIO2 was studied as a candidate gene for reproduction in sheep. Three pairs of primers were designed to detect single nucleotide polymorphisms (SNPs) of exon 2 of DIO2 in nonseasonal and seasonal reproduction breeds. The polymorphisms were detected using SeqMan II and analyzed by PCR-RFLP. The sheep DIO2 gene was cloned and its mutations were detected in five sheep breeds whose reproductive seasonality and litter sizes were different. Association analyses were performed to reveal the relationships between SNPs and reproductive seasonality as well as litter size in sheep. The results showed that a 1041-bp DNA fragment of the sheep DIO2 …
Characterization Of Porcine Adiponectin Gene (Adipoq) Polymorphismsand Their Association With Litter Size, Xiaodong Zhang, Ning Zhou, Jie Zhou, Ning Wang, Xiang Qin, Hui Dong, Yueyun Ding, Zongjun Yin
Characterization Of Porcine Adiponectin Gene (Adipoq) Polymorphismsand Their Association With Litter Size, Xiaodong Zhang, Ning Zhou, Jie Zhou, Ning Wang, Xiang Qin, Hui Dong, Yueyun Ding, Zongjun Yin
Turkish Journal of Veterinary & Animal Sciences
Litter size is one of the most important economic traits for pig production as it is directly related to production efficiency. To evaluate the effects of the adiponectin (ADIPOQ) gene on porcine litter size, we investigated ADIPOQ polymorphisms in three breeds, Wannan Black pigs, Berkshire pigs, and BW pigs (crossbred pigs produced from mating male Berkshire pigs and female Wannan Black pigs), using the PCR-SSCP method. Three SNPs (c. 178G > A, c. 1165A > G, and c. 1138G > A) were identified. In Wannan Black pigs, association analysis indicated that the c. 178G > A SNP genotype was significantly associated with an effect …