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Full-Text Articles in Medicine and Health Sciences
Oxidative Stress-Induced Dna Damage And Homocysteine Accumulation May Beinvolved In Ovarian Cancer Progression In Both Young And Old Patients, Shazia Anwer Bukhari, Kashaf Zafar, Muhammad Ibrahim Rajoka, Zubair Ibrahim, Sadia Javed, Rafshan Sadiq
Oxidative Stress-Induced Dna Damage And Homocysteine Accumulation May Beinvolved In Ovarian Cancer Progression In Both Young And Old Patients, Shazia Anwer Bukhari, Kashaf Zafar, Muhammad Ibrahim Rajoka, Zubair Ibrahim, Sadia Javed, Rafshan Sadiq
Turkish Journal of Medical Sciences
Background/aim: Biochemical, environmental, and genetic factors such as oxidative stress-induced DNA damage and homocysteine (Hcy) accumulation in the blood are involved in the development and progression of ovarian cancer. This study measured some biomarkers closely linked to the progression of ovarian cancer and also found their correlates. Materials and methods: Thirty patients were diagnosed with ovarian cancer using pelvic examination, transvaginal ultrasound, and cancer antibody (CA-125) measurement. Total oxidative stress (TOS), DNA damage, Hcy, malondialdehyde (MDA), total antioxidant status (TAS), and other biochemical parameters were determined. Results: TOS and DNA damage were positively and significantly correlated between themselves and were …
Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar
Serum Procalcitonin And C-Reactive Protein Kinetics As Indicators Of Treatmentoutcome In Hospitalized Patients With Community-Acquired Pneumonia, Mehmet Sezai̇ Taşbakan, Canan Gündüz, Abdullah Sayiner, Aykut Çi̇lli̇, Burcu Çelenk Karaboğa, Ayşin Şakar Coşkun, Feri̇de Durmaz Yaman, Oğuz Kilinç, Öznur Kiliç Soylar
Turkish Journal of Medical Sciences
Background/aim: There has been growing interest in the use of serum procalcitonin (PCT) and C-reactive protein (CRP) in patients with community-acquired pneumonia (CAP). The aim of this study was to investigate whether an assessment of fever, leukocyte count, and serum CRP and PCT levels on admission and during follow-up (day 3) provides any information about the clinical outcome in hospitalized patients with CAP. Materials and methods: Patients with a diagnosis of CAP who were admitted to and followed at four university hospitals were evaluated retrospectively using the Turkish Thoracic Society Pneumonia Database. Results: A total of 103 hospitalized CAP patients …
Liporotein-Associated Phospholipase-A2 Can Be A Diagnostic Marker Inthe Early Stage Diagnosis Of Acute Mesenteric Ischemia, Tarik Acar, Sedat Koçak, Başar Cander, Mehmet Ergi̇n, Cesareddi̇n Di̇kmetaş
Liporotein-Associated Phospholipase-A2 Can Be A Diagnostic Marker Inthe Early Stage Diagnosis Of Acute Mesenteric Ischemia, Tarik Acar, Sedat Koçak, Başar Cander, Mehmet Ergi̇n, Cesareddi̇n Di̇kmetaş
Turkish Journal of Medical Sciences
Background/aim: The purpose of this experimental study was to investigate the role of lipoprotein-associated phospholipase-A2 (Lp-PLA2) in the diagnosis of acute mesenteric ischemia (AMI) in the early stage. Materials and methods: Twenty-seven New Zealand rabbits were randomly divided into 3 groups in this study. Blood specimens were obtained from the groups at hours 0, 1, 3, and 6. Using the blood samples drawn from all groups, Lp-PLA2 and C-reactive protein (CRP) parameters were investigated. Results: There was a significant rise in the levels of both Lp-PLA2 and CRP starting at hour 1 (P < 0.05) (hour 1; Lp-PLA2, P = 0.003) in the ischemia group. In the sham group, the levels of Lp-PLA2 and CRP started to rise at hour 3 (P < 0.05) (hour 3; Lp-PLA2, P = 0.011). At hour 6 of ischemia, the area under the ROC curve was 100%, and the cut-off value of 63.91 ng/mL revealed a sensitivity of 88% and a specificity of 100% for Lp-PLA2. Conclusion: These findings showed the role of serum Lp-PLA2 and CRP levels in the early diagnosis of AMI. Thus, further studies are needed to describe the role of Lp-PLA2 in the early diagnosis of AMI.