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Full-Text Articles in Medicine and Health Sciences
Frequency Of Alpha-1 Antitrypsin Deficiency And Unexpected Results In Copd Patients In Turkey; Rare Variants Are Common, Mustafa Çörtük, Bariş Demi̇rkol, Meli̇h Akay Arslan, Umut İlhan, Yunus Emre Kalkan, Demet Turan, Şule Gül, Hali̇t Çinarka, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya
Frequency Of Alpha-1 Antitrypsin Deficiency And Unexpected Results In Copd Patients In Turkey; Rare Variants Are Common, Mustafa Çörtük, Bariş Demi̇rkol, Meli̇h Akay Arslan, Umut İlhan, Yunus Emre Kalkan, Demet Turan, Şule Gül, Hali̇t Çinarka, Kürşad Nuri̇ Baydi̇li̇, Erdoğan Çeti̇nkaya
Turkish Journal of Medical Sciences
Background/aim: Alpha-1 antitrypsin (?1-AT) is a protease inhibitor that is largely released from liver cells. It inhibits neutrophil elastase and its deficiency increases the risk of developing chronic obstructive pulmonary disease (COPD). The frequency of ?1-AT deficiency has been reported with different prevalence rates in different parts of the world. The most common ?1-AT variant causing ?1-AT deficiency is the Pi*Z allele. In this study, we aimed to determine the frequency of the ?1-AT genotypic variant in COPD patients in our country. Materials and methods: In this study, 196 consecutive COPD patients admitted to our clinic were included. In addition …
Effects Of Pulmonary Rehabilitation On Diaphragm Thickness And Contractility In Patients With Chronic Obstructive Pulmonary Disease, Seçi̇lay Güneş, Aysun Genç, Yeşi̇m Kurtai̇ş, Fatma Çi̇ftci̇, Serhat Hayme, Akin Kaya
Effects Of Pulmonary Rehabilitation On Diaphragm Thickness And Contractility In Patients With Chronic Obstructive Pulmonary Disease, Seçi̇lay Güneş, Aysun Genç, Yeşi̇m Kurtai̇ş, Fatma Çi̇ftci̇, Serhat Hayme, Akin Kaya
Turkish Journal of Medical Sciences
Background/aim: Studies are showing that pulmonary rehabilitation (PR) increases diaphragmatic excursion by decreasing hyperinflation in patients with chronic obstructive pulmonary disease (COPD). However, there is a lack of knowledge about its effects on the diaphragm thickness (dt) and contractility. This study aims to evaluate the dt and contractility before and after PR in patients with COPD. Materials and methods: All subjects participated in an out-patient PR of 6 weeks and 3 sessions per week prospectively. Dyspnea severity, the disease-specific quality of life (St. Georges Respiratory Questionnaire-SGRQ), pulmonary function tests (PFT), exercise capacity, the dt at the end of the expiration …
The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün
The Effect Of Comprehensive Multidisciplinary Pulmonary Rehabilitation On 5-Year Survival In Copd: Does Maintaining A Home Exercise Program Improve Survival?, Seher Satar, Mustafa Engi̇n Şahi̇n, Pinar Ergün
Turkish Journal of Medical Sciences
Background/aim: Chronic Obstructive Pulmonary Disease (COPD) is one of the most common causes of death worldwide. Therefore, optimizing medical therapy in the comprehensive management of the disease, as well as including pulmonary rehabilitation (PR) in the treatment, is essential. The goal of our study was to determine the impact of PR on the survival of COPD patients. Materials and methods: Between 2007-2015, 509 COPD patients who completed the PR constituted the PR group, while 167 patients who applied but could not complete it after the initial evaluations formed the control group. In the PR group, dyspnea perception, exercise capacity, muscle …
Patients With Copd Who Underwent Pulmonary Rehabilitation In Turkey: Prevalence, Distribution, And Mortality, Tarkan Özdemi̇r, İpek Candemi̇r, Pinar Ergün, Mustafa Hami̇dullah Türkkani, Orhan Koç
Patients With Copd Who Underwent Pulmonary Rehabilitation In Turkey: Prevalence, Distribution, And Mortality, Tarkan Özdemi̇r, İpek Candemi̇r, Pinar Ergün, Mustafa Hami̇dullah Türkkani, Orhan Koç
Turkish Journal of Medical Sciences
Background: Pulmonary rehabilitation (PR) is an effective, evidenced-based treatment. Despite its proven effect, it is still underused. The aim of this study was to present the number of patients with chronic obstructive pulmonary disease (COPD) who underwent PR, general mortality percentages, the rate of patients prescribed PR by pulmonologists, and the distribution of institutions where PR was performed between 2008 and 2016 in Turkey. Materials and methods: The documents were obtained from Turkish Institution of Social Insurance. Ages, sexes, and numbers of patients with COPD who underwent PR between 2008 and 2016 were recorded. The number of patients with COPD …
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Correlation Of Serum Fatty Acid Binding Protein-4 And Interleukin-6 With Airflowlimitation And Quality Of Life In Stable And Acute Exacerbation Of Copd, Mohammad Reza Aslani, Zeynab Ghazaei, Hassan Ghobadi
Turkish Journal of Medical Sciences
Background/aim: The serum fatty acid binding protein 4 (FABP-4) level increases in chronic inflammatory diseases. The present study aimed to examine serum FABP-4 and interleukin (IL)-6 levels in patients with stable and acute exacerbation of chronic obstructive pulmonary disease (COPD) and the correlation of these markers with airflow limitation. Materials and methods: We measured serum FABP-4 and IL-6 levels in 60 COPD patients [30 stable COPD (SCOPD), and 30 acute exacerbation of COPD (AECOPD)], and 30 healthy subjects and compared them with airflow limitation according to the COPD stage in the Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) criteria, …
Frequency Of Sarcopenia And Associated Outcomes In Patients With Chronic Obstructive Pulmonary Disease, Havva Demi̇rci̇oğlu, Fatma Gökşi̇n Ci̇han, Ruhuşen Kutlu, Şebnem Yosunkaya, Adi̇l Zamani̇
Frequency Of Sarcopenia And Associated Outcomes In Patients With Chronic Obstructive Pulmonary Disease, Havva Demi̇rci̇oğlu, Fatma Gökşi̇n Ci̇han, Ruhuşen Kutlu, Şebnem Yosunkaya, Adi̇l Zamani̇
Turkish Journal of Medical Sciences
Background/aim: We aimed to evaluate the prevalence of sarcopenia and associated outcomes in patients with chronic obstructive pulmonary disease (COPD). Materials and methods: This cross-sectional study was performed on 219 patients aged 50 years and over who were diagnosed with chronic obstructive pulmonary disease (COPD) according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines. The study included 196 (89.5%) male and 23 (10.5%) female patients. The mean age of the patients was 66.9 ± 10.1 years. To diagnose sarcopenia, muscle function was determined by a gait speed test. Muscle strength was assessed with a hand dynamometer and …
Does Hand Grip Strength Decrease In Chronic Obstructive Pulmonary Disease Exacerbation? A Cross-Sectional Study, Zeynep Turan, Özden Özyemi̇şci̇ Taşkiran, Zeynep Erden, Nurdan Köktürk, Gülçi̇n Kaymak Karataş
Does Hand Grip Strength Decrease In Chronic Obstructive Pulmonary Disease Exacerbation? A Cross-Sectional Study, Zeynep Turan, Özden Özyemi̇şci̇ Taşkiran, Zeynep Erden, Nurdan Köktürk, Gülçi̇n Kaymak Karataş
Turkish Journal of Medical Sciences
Background/aim: Respiratory and peripheral muscle strength are reduced in chronic obstructive pulmonary disease (COPD). There is a well-known correlation between handgrip strength (HGS) and strenght extremity muscles. Our aim in this study was to measure HGS and investigate the related factors in COPD patients with exacerbation.Materials and methods: Subjects with COPD exacerbation (n = 101) and stable COPD (n = 22), and subjects without COPD (n = 201), were enrolled in this study. Age, sex, and body mass index were similar. HGS was measured using a Vigorimeter. Pulmonary function tests and 6-min walk tests were performed.Results: The mean HGS was …
Diaphragmatic Thickness In Chronic Obstructive Lung Disease And Relationship With Clinical Severity Parameters, Nalan Ogan, Yusuf Aydemi̇r, Togay Evri̇n, Gökçe Kaan Ataç, Ayşe Baha, Burak Kati̇poğlu, Banu Süzen, Evri̇m Eylem Akpinar
Diaphragmatic Thickness In Chronic Obstructive Lung Disease And Relationship With Clinical Severity Parameters, Nalan Ogan, Yusuf Aydemi̇r, Togay Evri̇n, Gökçe Kaan Ataç, Ayşe Baha, Burak Kati̇poğlu, Banu Süzen, Evri̇m Eylem Akpinar
Turkish Journal of Medical Sciences
Background/aim: Sonographic assessment of diaphragm structure and function would be a useful clinical tool in patients with chronic obstructive pulmonary disease (COPD). Our aim was to determine the muscle thickness of the diaphragm and the usefulness of clinical practice in patients with COPD.Materials and methods: The diaphragmatic thickness of 34 COPD patients and 34 healthy subjects was measured during tidal volume (Tmin) and deep inspiration (Tmax) on both sides using a B-mode ultrasound. The body mass index and the modified Medical Research Council (mMRC) index values were reported.Results: There was no correlation among TminR (P = 0.134), TminL (P = …
The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin
The Effect Of Hypoxia On Hearing Function, Nevreste Di̇dem Sonbay Yilmaz, Cem Saka, Burcu Arslan, Nurdan Aygener Yeşi̇lyurt, Di̇lek Saka, Sadik Ardiç, İstemi̇han Akin
Turkish Journal of Medical Sciences
Background/aim: This study was conducted to determine the critical partial oxygen pressure (pO2) value that would impair hearing function by evaluating the effects of hypoxia on hearing function in subjects diagnosed with chronic obstructive pulmonary disease (CPOD).Materials and methods: The study included 25 male and 5 female patients referred to our clinic who were diagnosed with COPD, according to spirometry and PaO2 values, and who did not show pathology upon autoscopic examination. The control group consisted of 14 female and 16 male patients who had no lung disease and were in the same age range as the COPD group. Results: …
8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng
8-Hydroxy-2'-Deoxyguanosine As A Biomarker Of Oxidative Stress In Acute Exacerbation Of Chronic Obstructive Pulmonary Disease, Xing Liu, Kaili Deng, Sixia Chen, Yunshi Zhang, Jing Yao, Xiaoqin Weng, Yang Zhang, Tianming Gao, Ganzhu Feng
Turkish Journal of Medical Sciences
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a biomarker of oxidative stress and has been implicated in many diseases. The aim of this study was to investigate the clinical value of plasma 8-OHdG level in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).Materials and methods: A total of 154 subjects were enrolled in this study, including 20 healthy volunteers, 24 COPD patients in the stable phase, and 110 AECOPD patients. Peripheral blood samples, demographic information, and clinical characteristics were collected from all subjects at the time of being recruited into the study. Plasma 8-OHdG level was detected by enzyme-linked immunosorbent assay.Results: 8-OHdG …
The Validity And Reliability Of The Turkish Version Of The Leicester Cough Questionnairein Copd Patients, Fi̇kret Kurhan, Tuğba Göktalay, Yavuz Havlucu, Seçi̇l Sari, Ayşe Arzu Yorgancioğlu, Pinar Çeli̇k, Ayşin Şakar Coşkun
The Validity And Reliability Of The Turkish Version Of The Leicester Cough Questionnairein Copd Patients, Fi̇kret Kurhan, Tuğba Göktalay, Yavuz Havlucu, Seçi̇l Sari, Ayşe Arzu Yorgancioğlu, Pinar Çeli̇k, Ayşin Şakar Coşkun
Turkish Journal of Medical Sciences
Background/aim: The reliability and validity of the Turkish version of the Leicester Cough Questionnaire (LCQ) have been evaluated before. This study aimed to validate the Turkish version of the LCQ in chronic obstructive pulmonary disease (COPD) patients with cough. Materials and methods: COPD (GOLD B, C, D) patients over age 40 (n = 75) and healthy volunteers as a control group (n = 75) were included. A sociodemographic data form, the LCQ, the Short Form-36 (SF-36) quality of life questionnaire, and the World Health Organization Quality of Life Brief Form for Turkish people were completed. The internal reliability of the …
Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü
Sex-Related Differences In Copd Assessment Test Scores Of Copd Populationswith Or Without Significant Anxiety And/Or Depression, Yelda Varol, Ceyda Anar, Pinar Çi̇men, Mehmet Ünlü, Hüseyi̇n Hali̇lçolar, Sali̇h Zeki̇ Güçlü
Turkish Journal of Medical Sciences
Background/aim: Sex-related differences have not been thoroughly explored in chronic obstructive pulmonary disease (COPD). We aimed to evaluate possible sex-related differences in COPD Assessment Test (CAT) scores of COPD patients with or without significant anxiety and/or depression. Materials and methods: Stable COPD patients were prospectively enrolled in the study between July 2013 and April 2014. Levels of anxiety, depression, dyspnea, and health-related quality of life parameters were assessed using specific questionnaires, including the CAT and others. Demographic and clinical data were recorded and physiological tests were performed. All the data were compared to determine any sex-related differences. Results: A total …
Factors Associated With The Rate Of Copd Exacerbations That Require Hospitalization, Radisa Pavlovic, Srdjan Stefanovic, Zorica Lazic, Slobodan Jankovic
Factors Associated With The Rate Of Copd Exacerbations That Require Hospitalization, Radisa Pavlovic, Srdjan Stefanovic, Zorica Lazic, Slobodan Jankovic
Turkish Journal of Medical Sciences
Background/aim: Exacerbations are key events in chronic obstructive pulmonary disease (COPD). Frequent exacerbations occurring during the natural course of COPD lead to deterioration of health-related quality of life and are major causes of morbidity and mortality. The aim of this study was to identify factors independently associated with frequent severe exacerbations of COPD that require hospitalization. Materials and methods: A case-control study was performed to analyze risk factors and frequency of severe exacerbations, which were defined by the GOLD guideline criteria. Stepwise multivariate regression was used to determine the significant predictors of frequent exacerbations. Results: Results revealed five independent predictors …
Comparison Of Helmet And Facial Mask During Noninvasiveventilation In Patients With Acute Exacerbation Of Chronic Obstructivepulmonary Disease: A Randomized Controlled Study, Özlem Çakir Gürbüz, Ali̇ Alagöz, Fatma Ulus, Mehtap Tunç, Şazi̇ye Şahi̇n
Comparison Of Helmet And Facial Mask During Noninvasiveventilation In Patients With Acute Exacerbation Of Chronic Obstructivepulmonary Disease: A Randomized Controlled Study, Özlem Çakir Gürbüz, Ali̇ Alagöz, Fatma Ulus, Mehtap Tunç, Şazi̇ye Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: Noninvasive mechanical ventilation (NIMV) is an approach to prevent complications in acute respiratory failure. In this study we aimed to compare the efficacy of a full face mask and a helmet in chronic obstructive pulmonary disease (COPD). Materials and methods: Fifty patients were divided randomly into 2 groups as full face mask (Group F) and helmet (Group H). Demographic data, forced expiratory volume at 1 s (FEV1), additional disease, hemodynamic parameters, respiratory rate, APACHE II score, peripheral O2 saturation (SpO2), arterial blood gases (ABG), patient tolerance scale (PTS) score, and fraction of inspired oxygen (FiO2) were recorded. Parameters were …
Association Analyses Of Oxidative Stress, Aerobic Capacity, Daily Physical Activity, And Body Composition Parameters In Patients With Mild To Moderate Copd, Abdurrahman Genç, Kağan Üçok, Ümi̇t Şener, Tülay Koyuncu, Olcay Akar, Sefa Çeli̇k, Mehmet Ünlü
Association Analyses Of Oxidative Stress, Aerobic Capacity, Daily Physical Activity, And Body Composition Parameters In Patients With Mild To Moderate Copd, Abdurrahman Genç, Kağan Üçok, Ümi̇t Şener, Tülay Koyuncu, Olcay Akar, Sefa Çeli̇k, Mehmet Ünlü
Turkish Journal of Medical Sciences
To investigate total oxidant and antioxidant status, maximal aerobic capacity, daily physical activity, pulmonary functions, and body composition changes, as well as the associations among these parameters, in patients with mild to moderate chronic obstructive pulmonary disease (COPD) versus healthy controls. Materials and methods: The study included 30 male patients newly diagnosed with COPD and 30 body mass index-matched, nonsmoker male controls. Maximal aerobic capacity, daily physical activity, total oxidant and antioxidant status, pulmonary function tests, body composition, and anthropometric parameters were measured. Results: Maximal aerobic capacity and total antioxidant values were lower in patients with COPD compared to the …
Effect Of The Presence Of Pneumonia On Noninvasive Ventilation Success In Chronic Obstructive Pulmonary Disease Cases With Acute Hypercapnic Respiratory Failure, Serdar Akpinar, Kazim Rollas, Evri̇m Eylem Akpinar, Ali̇ Alagöz, Nazi̇re Uçar, Yusuf Tuğrul Şi̇pi̇t
Effect Of The Presence Of Pneumonia On Noninvasive Ventilation Success In Chronic Obstructive Pulmonary Disease Cases With Acute Hypercapnic Respiratory Failure, Serdar Akpinar, Kazim Rollas, Evri̇m Eylem Akpinar, Ali̇ Alagöz, Nazi̇re Uçar, Yusuf Tuğrul Şi̇pi̇t
Turkish Journal of Medical Sciences
To investigate the effect of the presence of pneumonia on the success of noninvasive mechanical ventilation (NIMV) in chronic obstructive pulmonary disease (COPD) cases with acute respiratory failure. Materials and methods: Sixty patients admitted to the intensive care unit (ICU) due to COPD exacerbation were included. The patients were divided into 2 groups as those with pneumonia (Group 1) and without pneumonia (Group 2). According to initial pH values, cases were also divided into 3 subgroups based on pH values. C-reactive protein (CRP), APACHE II scores, requirement of endotracheal intubation, mortality, and duration of ICU and hospital stay were also …
Effects Of Long-Acting Beta-2 Agonist Treatment On Daily Energy Balance And Body Composition In Patients With Chronic Obstructive Pulmonary Disease, Abdurrahman Genç, Kağan Üçok, Ersi̇n Günay, Yücel Gönül, Hati̇ce Karabacak, Ümi̇t Şener, Serkan Nural, Mehmet Ünlü
Effects Of Long-Acting Beta-2 Agonist Treatment On Daily Energy Balance And Body Composition In Patients With Chronic Obstructive Pulmonary Disease, Abdurrahman Genç, Kağan Üçok, Ersi̇n Günay, Yücel Gönül, Hati̇ce Karabacak, Ümi̇t Şener, Serkan Nural, Mehmet Ünlü
Turkish Journal of Medical Sciences
The aim of this study was to investigate the effects of long-acting beta-2 agonist (formoterol) treatment on the resting metabolic rate (RMR), daily physical activity, body composition and anthropometry, nutritional status, and quality of life of patients with chronic obstructive pulmonary disease (COPD). Materials and methods: A total of 30 male patients who were diagnosed with COPD participated in the study. The RMR was determined using an indirect calorimeter, daily physical activity was measured with an accelerometer, and body composition was established by bioelectric impedance analysis. Body circumference and skinfold thickness measurements were carried out. Pulmonary function tests were performed …
The Effects Of Smoking On Glutathione Levels Inbronchoalveolar Lavage Fluid, Füsun Alataş, Necla Özdemi̇r, Özkan Alataş, Si̇nan Ergi̇nel, Muzaffer Meti̇ntaş, Rana Işik
The Effects Of Smoking On Glutathione Levels Inbronchoalveolar Lavage Fluid, Füsun Alataş, Necla Özdemi̇r, Özkan Alataş, Si̇nan Ergi̇nel, Muzaffer Meti̇ntaş, Rana Işik
Turkish Journal of Medical Sciences
Cigarette smoke contains high concentrations of oxidants and reactive oxygen species. The aim of this study was to evaluate the effect of long-term cigarette smoking on glutathione (GSH) levels in bronchoalveolar lavage (BAL) fluid. Nineteen current cigarette smokers and seven healthy nonsmoking volunteers were included in the study. BAL was performed by infusion of five sequential 20 ml aliquots and each aliquot was immediately aspirated. The levels of GSH were determined in BAL fluids. The epithelial lining fluid volume was calculated by the ratio of urea concentration in BAL fluid to that in serum. Lower GSH levels were observed in …