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Full-Text Articles in Medicine and Health Sciences
Gene Expression Studies In Multiple Sclerosis, Lotti Tajouri, Francesca Fernandez, Lyn Griffiths
Gene Expression Studies In Multiple Sclerosis, Lotti Tajouri, Francesca Fernandez, Lyn Griffiths
Lotti Tajouri
Bacterial alginate genes are chromosomal and fairly widespread among rRNA homology group I Pseudomonads and Azotobacter. In both genera, the genetic pathway of alginate biosynthesis is mostly similar and the identified genes are identically organized into biosynthetic, regulatory and genetic switching clusters. In spite of these similarities, still there are transcriptional and functional variations between P. aeruginosa and A. vinelandii. In P. aeruginosa all biosynthetic genes except algC transcribe in polycistronic manner under the control of algD promoter while in A. vinelandii, these are organized into many transcriptional units. Of these, algA and algC are transcribed each from two different …
No Association Between Mthfr A1298c And Mtrr A66g Polymorphisms, And Ms In An Australian Cohort, A. Szvetko, J. Fowdar, J. Nelson, N. Colson, L. Tajouri, P. Csurhes, M. Pender, L. Griffiths
No Association Between Mthfr A1298c And Mtrr A66g Polymorphisms, And Ms In An Australian Cohort, A. Szvetko, J. Fowdar, J. Nelson, N. Colson, L. Tajouri, P. Csurhes, M. Pender, L. Griffiths
Lotti Tajouri
Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by CNS inflammation and demyelination of nerve axons. Methionine synthase reductase (MTRR) is an enzyme that catalyzes the remethylation of homocysteine (Hcy) to methionine via cobalamin and folate dependant reactions. Cobalamin acts as an intermediate methyl carrier between methylenetetrahydrofolate reductase (MTHFR) and Hcy. MTRR plays a critical role in maintaining cobalamin in an active form and is consequently an important determinant of total plasma Hcy (pHcy) concentrations. Elevated intracellular pHcy levels have been suggested to play a …
Allelic Variation Investigation Of The Estrogen Receptor Within An Australian Multiple Sclerosis Population, Lotti Tajouri, Francesca Fernandez, Sophie Tajouri, Geraldine Detriche, Attila Szvetko, Natalie Colson, Peter Csurhes, Michael Pender, Lyn Griffiths
Allelic Variation Investigation Of The Estrogen Receptor Within An Australian Multiple Sclerosis Population, Lotti Tajouri, Francesca Fernandez, Sophie Tajouri, Geraldine Detriche, Attila Szvetko, Natalie Colson, Peter Csurhes, Michael Pender, Lyn Griffiths
Lotti Tajouri
Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a ratio of 3:2 female to male. Objectives: To investigate variation within the estrogen receptor 1 (ESR1) polymorphism gene in an Australian MS case-control population using two intragenic restriction fragment length polymorphisms; the G594A located in exon 8 detected with the BtgI restriction enzyme and T938C located in intron 1, detected with PvuII. One hundred and ten Australian MS patients were studied, with patients classified clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS …