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Australian Clinical Toxicology Investigators Collaboration Randomized Trial Of Different Loading Infusion Rates Of N-Acetylcysteine [6], I Gawarammana, S Greene, Paul Dargan, Alison Jones
Australian Clinical Toxicology Investigators Collaboration Randomized Trial Of Different Loading Infusion Rates Of N-Acetylcysteine [6], I Gawarammana, S Greene, Paul Dargan, Alison Jones
Alison L Jones
Adverse reactions to N-acetylcysteine are reported in 6% to 23% of patients who are administered the antidote for treatment of paracetamol poisoning.1 Because paracetamol is the most common pharmaceutical product taken in overdose in many countries, it is essential that attempts be made to prevent or minimize adverse effects caused by N-acetylcysteine. We congratulate Kerr et al2 on their attempt to address this important issue.
What's New In Toxicology?, Alison Jones, Paul Dargan
What's New In Toxicology?, Alison Jones, Paul Dargan
Alison L Jones
Poisoning in children under 5 years of age is common, the majority of cases are accidental ingestions. Children may ingest pharmaceutical products, household substances, chemicals, plants or street drugs. Most children develop no clinical features or only mild effects and the challenge in managing these children is to identify the 1% who may go on to develop severe clinical effects and require specific management. The latest guidelines on gastric decontamination are reviewed together with developments in the management of poisoning with paracetamol, tricyclic antidepressants, iron, lead and ethylene glycol and methanol. Prevention of childhood poisoning is important and the use …
Over-The-Counter Analgesics: A Toxicology Perspective., Alison Jones
Over-The-Counter Analgesics: A Toxicology Perspective., Alison Jones
Alison L Jones
The decision to use any analgesic is a balance of benefit and risk. In the case of analgesics, it is important to balance the therapeutic benefit against both the risk in therapeutic use and the risk (and ease of treatment) in overdose. Paracetamol in therapeutic dose carries little risk of adverse events. Less than 0.1% of the estimated 30 million paracetamol users in the United Kingdom attend hospital with a paracetamol overdose each year, and approximately 200 people die, most of whom presented late or did not receive the antidote, N-acetylcysteine, within 12 hours. Nonsteroidal anti-inflammatory drugs (NSAIDs) have greater …
Hepatic Toxicology, Alison Jones, Paul Dargan
Hepatic Toxicology, Alison Jones, Paul Dargan
Alison L Jones
Many potentially toxic substances enter the body via the gastrointestinal tract. As the blood supply from the gastrointestinal tract (through the portal vein) drains into the liver, the liver comes into contact with them, and this exposure often is at a higher concentration than that received by other tissues. The liver is essential for the metabolic disposal of virtually all xenobiotics. This process is achieved mostly without injury to the liver itself or to other organs.
Toxicology, Alison L. Jones
Toxicology, Alison L. Jones
Alison L Jones
Introduction Poisoning is one of the commonest medical emergencies in the UK and accounts for 10%-20% of acute medical admissions. The most common causes of poisoning in the UK are outlined in Table 13.1. Assessing poisoned patients and managing them is an exciting challenge because they often have complex psychosocial issues, together with general medical problems, and have taken toxins in sizeable doses. They require the best of clinical skills to provide the best outcome. Sadly, poisoned patients do not always meet with the sympathies of admitting doctors because th? ~ay be perceived to have "self-inflicted illness." This is a …
Fab Antibody Fragments: Some Applications In Clinical Toxicology, Robert Flanagan, Alison Jones
Fab Antibody Fragments: Some Applications In Clinical Toxicology, Robert Flanagan, Alison Jones
Alison L Jones
This review provides current information on the use of antigen-binding fragments (Fab) from cleaved antibodies to treat poisoning with digoxin and other potent, low formula mass poisons, such as colchicine and tricyclic antidepressants. Anti-digoxin Fab fragments have been used successfully for many years in the management of severe poisoning with digoxin, digitoxin, and a range of other structurally related compounds, including cardiotoxins from Nerium and Thevetia sp. (oleander) and Bufo sp. (toads). However, their main use remains treating digoxin poisoning. Equimolar doses of anti-digoxin Fab fragments completely bind digoxin in vivo. The approximate dose of Fab fragments (mg) is 80 …
Churchill's Pocketbook Of Toxicology, Alison Jones, Paul Dargan
Churchill's Pocketbook Of Toxicology, Alison Jones, Paul Dargan
Alison L Jones
No abstract provided.