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Multiple-Choice Questions In Clinical Gastroenterology, Malcolm Bateson, R Barton, Denis Burke, P Cann, J Cox, Graham Curry, S Ghosh, W Hislop, D Hopwood, D Johnston, Alison Jones, Sarah Jowett, A Macklon, K Matthewson, J O'Donohue, K Palmer, T Reilly, J Rose, Nurani Sivaramakrishnan, Heather Smith, J Stephen, Peter Trewby, John Wilson, R Wood
Multiple-Choice Questions In Clinical Gastroenterology, Malcolm Bateson, R Barton, Denis Burke, P Cann, J Cox, Graham Curry, S Ghosh, W Hislop, D Hopwood, D Johnston, Alison Jones, Sarah Jowett, A Macklon, K Matthewson, J O'Donohue, K Palmer, T Reilly, J Rose, Nurani Sivaramakrishnan, Heather Smith, J Stephen, Peter Trewby, John Wilson, R Wood
Alison L Jones
In the middle of the twelfth century the Scottish Sovereign's rule extended into England north of the River Tees. The territory of this ancient kingdom of CaledonIa is today an area where the National Health Service functions best and academic medicine flourishes. Gastroenterology is particularly strong and so it is especially appropriate that colleagues from north Britain contribute to this collection of multiple-choice questions (MCQs). These MCQs focus on common clinical problems approached in different ways and on recent advances. Many are based on real patients under the clinical care of the authors. Often detailed explanations of the answers are …
Australian Clinical Toxicology Investigators Collaboration Randomized Trial Of Different Loading Infusion Rates Of N-Acetylcysteine [6], I Gawarammana, S Greene, Paul Dargan, Alison Jones
Australian Clinical Toxicology Investigators Collaboration Randomized Trial Of Different Loading Infusion Rates Of N-Acetylcysteine [6], I Gawarammana, S Greene, Paul Dargan, Alison Jones
Alison L Jones
Adverse reactions to N-acetylcysteine are reported in 6% to 23% of patients who are administered the antidote for treatment of paracetamol poisoning.1 Because paracetamol is the most common pharmaceutical product taken in overdose in many countries, it is essential that attempts be made to prevent or minimize adverse effects caused by N-acetylcysteine. We congratulate Kerr et al2 on their attempt to address this important issue.
Fab Antibody Fragments: Some Applications In Clinical Toxicology, Robert Flanagan, Alison Jones
Fab Antibody Fragments: Some Applications In Clinical Toxicology, Robert Flanagan, Alison Jones
Alison L Jones
This review provides current information on the use of antigen-binding fragments (Fab) from cleaved antibodies to treat poisoning with digoxin and other potent, low formula mass poisons, such as colchicine and tricyclic antidepressants. Anti-digoxin Fab fragments have been used successfully for many years in the management of severe poisoning with digoxin, digitoxin, and a range of other structurally related compounds, including cardiotoxins from Nerium and Thevetia sp. (oleander) and Bufo sp. (toads). However, their main use remains treating digoxin poisoning. Equimolar doses of anti-digoxin Fab fragments completely bind digoxin in vivo. The approximate dose of Fab fragments (mg) is 80 …
Prolonged Clinical Effects In Modified-Release Amitriptyline Poisoning, Niall O'Connor, S Greene, Paul Dargan, Duncan Wyncoll, Alison Jones
Prolonged Clinical Effects In Modified-Release Amitriptyline Poisoning, Niall O'Connor, S Greene, Paul Dargan, Duncan Wyncoll, Alison Jones
Alison L Jones
Background. Tricyclic antidepressant poisoning is often associated with significant cardiovascular and central nervous system toxicity. Effective treatment includes the use of appropriate gastric decontamination techniques, the administration of sodium bicarbonate, and meticulous supportive care. Tricylcic antidepressant toxicity typically lasts 24–48 hours following a significant overdose. Case Report. We describe a case of tricyclic antidepressant poisoning where significant clinical toxicity (QRS prolongation, metabolic acidosis) was observed for up to 4 days following ingestion of a modified-release preparation of amitriptyline. Successful patient recovery was associated with the use of multidose activated charcoal and repeated administration of intravenous sodium bicarbonate. Conclusions. Clinicians should …