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Full-Text Articles in Medicine and Health Sciences
Portal And Systemic Haemodynamic Action Of N-Acetylcysteine In Patients With Stable Cirrhosis, Alison Jones, I Bangash, I.A.D Bouchier, P Hayes
Portal And Systemic Haemodynamic Action Of N-Acetylcysteine In Patients With Stable Cirrhosis, Alison Jones, I Bangash, I.A.D Bouchier, P Hayes
Alison L Jones
The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary bilary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a significant fall in systemic and pulmonary vascular resistance. Cardiac index increased but estimated liver blood flow and portal venous pressure did not change significantly. Administration of N-acetylcysteine resulted in increased oxygen delivery to the tissues because of the increased cardiac index but this was not accompanied by a rise in either arteriovenous oxygen extraction ratio or mean …
Haemodynamic Parameters Predicting Variceal Haemorrhage And Survival In Alcoholic Cirrhosis, A Stanley, I Robinson, E Forrest, Alison Jones, P Hayes
Haemodynamic Parameters Predicting Variceal Haemorrhage And Survival In Alcoholic Cirrhosis, A Stanley, I Robinson, E Forrest, Alison Jones, P Hayes
Alison L Jones
No abstract provided.
Portal And Systemic Haemodynamic Response To Acute And Chronic Administration Of Low And High Dose Isosorbide-5-Mononitrate In Patients With Cirrhosis, Alison Jones, I Bangash, James Walker, K Simpson, N Finlayson, P Hayes
Portal And Systemic Haemodynamic Response To Acute And Chronic Administration Of Low And High Dose Isosorbide-5-Mononitrate In Patients With Cirrhosis, Alison Jones, I Bangash, James Walker, K Simpson, N Finlayson, P Hayes
Alison L Jones
Oral isosorbide-5-mononitrate (Is-5-Mn) was given in doses of 10 and 40 mg acutely and chronically (twice daily for four weeks), allowing a nitrate free interval to 25 patients with cirrhosis. Both 10 mg and 40 mg Is-S-Mn reduced the hepatic venous pressure gradient acutely and chronically, without evidence of tolerance. This was achieved by a reduction in the wedged hepatic venous pressure. The effect on mean azygos blood flow was variable with no significant mean change seen acutely or after chronic use with either dose. The variability was dependent not on the dose used but on the initial azygos flow; …
Analysis Of Serial Serum Alpha-Fetoprotein Concentrations In Patients With Cirrhosis, Alison Jones, J Plevris, C Shearing, I.A.D Bouchier, P Hayes
Analysis Of Serial Serum Alpha-Fetoprotein Concentrations In Patients With Cirrhosis, Alison Jones, J Plevris, C Shearing, I.A.D Bouchier, P Hayes
Alison L Jones
No abstract provided.
The Effect Of Nitric Oxide Synthase Inhibition On Portal Pressure And Azygos Blood Flow In Patients With Cirrhosis, E Forrest, Alison Jones, John Dillon, James Walker, P Hayes
The Effect Of Nitric Oxide Synthase Inhibition On Portal Pressure And Azygos Blood Flow In Patients With Cirrhosis, E Forrest, Alison Jones, John Dillon, James Walker, P Hayes
Alison L Jones
It has been proposed that the hyperdynamic circulation found in cirrhosis is mediated by nitric oxide released through the induction of nitric oxide synthase. To investigate this the effect of the nitric oxide synthase inhibitor, N~-monomethyl-L-arginine (LNMMA), was studied upon the portal circulation. After a 30-min infusion of 3 mg/kg of L-NMMA there was a significant fall in heart rate from 83.2+_4.4 to 74.2-+3.9 bpm (p=0.005), and a significant rise in mean arterial pressure from 91.6+_2.2 to 103.7+_3.2 mmHg, p=0.004). There was, however, no change in hepatic venous pressure gradient (16.7+_1.5 to I6.1+_1.7 mmHg, p=0.477) nor in azygos venous blood …