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Full-Text Articles in Medicine and Health Sciences
Paracetamol Poisoning: Can It Be Prevented? , E Norman, R Dhairiwan, Paul I. Dargan, Craig I. Wallace, Alison L. Jones
Paracetamol Poisoning: Can It Be Prevented? , E Norman, R Dhairiwan, Paul I. Dargan, Craig I. Wallace, Alison L. Jones
Alison L Jones
No abstract provided.
Should Methionine Be Added To Every Paracetamol Tablet?, Alison Jones, P Hayes, A Proudfoot, J Vale, L Prescott
Should Methionine Be Added To Every Paracetamol Tablet?, Alison Jones, P Hayes, A Proudfoot, J Vale, L Prescott
Alison L Jones
Paracetamol is commonly used for self poisoning, and the costs of treating the resulting liver failure in the few who develop it are high. The morbidity could be avoided by adding methionine to paracetamol tablets, but this would mean that the millions of people who take paracetamol responsibly would have to take methionine unnecessarily. Alison Jones and colleagues and Edward Krenzelok debate the issue.
Should All Patients With Unexplained Anaemia Be Screened For Chronic Lead Poisoning?, I Gawarammana, Paul Dargan, S Woodcock, M Sculley, Ivan House, David Wood, Alison Jones
Should All Patients With Unexplained Anaemia Be Screened For Chronic Lead Poisoning?, I Gawarammana, Paul Dargan, S Woodcock, M Sculley, Ivan House, David Wood, Alison Jones
Alison L Jones
No abstract provided.
Drug Misuse Should Always Be Considered In Young People With Impaired Consciousness, K R. Whelan, Alison L. Jones, Paul I. Dargan
Drug Misuse Should Always Be Considered In Young People With Impaired Consciousness, K R. Whelan, Alison L. Jones, Paul I. Dargan
Alison L Jones
We agree with Ikeda et al that the absence of systolic hypertension may provide some discriminatory power towards exclusion of brain lesions, be they ischaemic, haemorrhagic, or space occupying in nature.1 However, we disagree with them that neurological examination of patients with impaired consciousness is often a waste of time and resources and can delay diagnosis.
Should A Lower Treatment Line Be Used When Treating Paracetamol Poisoning In Patients With Chronic Alcoholism? A Case Against, Paul Dargan, Alison Jones
Should A Lower Treatment Line Be Used When Treating Paracetamol Poisoning In Patients With Chronic Alcoholism? A Case Against, Paul Dargan, Alison Jones
Alison L Jones
The widespread practice of using a lower plasma paracetamol (acetaminophen) concentration threshold for the treatment of paracetamol poisoning in patients with chronic alcoholism has been introduced on the basis of anecdotal case reports. In animals, acute alcohol loading inhibits toxic metabolic activation of paracetamol whilst chronic alcohol administration results in cytochrome P450 (CYP) 2E1 induction with increased toxic metabolic activation of paracetamol by CYP2E1 and increased hepatotoxicity. However, due to species differences in CYP expression, activity and induction, it is not possible extrapolate the results of these animal studies to clinical situations in humans. Isoenzymes are also responsible for the …
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Alison L Jones
Since the 1970s, N-acetylcysteine (NAC) has shown proven efficacy as an antidote for acetaminophen (APAP) poisoning and APAP-induced liver failure for early presenters. The current evidence of benefits of NAC for late presenters is controversial because of the poor understanding of the mechanism of late toxicity. In the previous issue of Critical Care, Yang and colleagues use a mouse model to demonstrate that NAC in doses similar to those used therapeutically to treat APAP poisoning in humans impairs liver regenerative capacity and that the effect is more pronounced when administered for a longer duration. Studies based on cell cultures support …