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Full-Text Articles in Medicine and Health Sciences
Portal And Systemic Haemodynamic Action Of N-Acetylcysteine In Patients With Stable Cirrhosis, Alison Jones, I Bangash, I.A.D Bouchier, P Hayes
Portal And Systemic Haemodynamic Action Of N-Acetylcysteine In Patients With Stable Cirrhosis, Alison Jones, I Bangash, I.A.D Bouchier, P Hayes
Alison L Jones
The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary bilary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a significant fall in systemic and pulmonary vascular resistance. Cardiac index increased but estimated liver blood flow and portal venous pressure did not change significantly. Administration of N-acetylcysteine resulted in increased oxygen delivery to the tissues because of the increased cardiac index but this was not accompanied by a rise in either arteriovenous oxygen extraction ratio or mean …
Australian Clinical Toxicology Investigators Collaboration Randomized Trial Of Different Loading Infusion Rates Of N-Acetylcysteine [6], I Gawarammana, S Greene, Paul Dargan, Alison Jones
Australian Clinical Toxicology Investigators Collaboration Randomized Trial Of Different Loading Infusion Rates Of N-Acetylcysteine [6], I Gawarammana, S Greene, Paul Dargan, Alison Jones
Alison L Jones
Adverse reactions to N-acetylcysteine are reported in 6% to 23% of patients who are administered the antidote for treatment of paracetamol poisoning.1 Because paracetamol is the most common pharmaceutical product taken in overdose in many countries, it is essential that attempts be made to prevent or minimize adverse effects caused by N-acetylcysteine. We congratulate Kerr et al2 on their attempt to address this important issue.
Antidotes 2. Sulphydryl Donors (N-Acetylcysteine, Methionine), Robert Flanagan, Alison Jones
Antidotes 2. Sulphydryl Donors (N-Acetylcysteine, Methionine), Robert Flanagan, Alison Jones
Alison L Jones
No abstract provided.
Pharmacokinetics Of N-Acetylcysteine Are Altered In Patients With Chronic Liver Disease, Alison Jones, D Jarvie, D Simpson, P Hayes, L Prescott
Pharmacokinetics Of N-Acetylcysteine Are Altered In Patients With Chronic Liver Disease, Alison Jones, D Jarvie, D Simpson, P Hayes, L Prescott
Alison L Jones
The threshold plasma paracetamol concentration at which N-acetylcysteine (NAC) treatment is recommended to treat paracetamol poisoning in a patient with induced liver enzymens (for example, with chronic liver disease or taking anticonvulsant drugs) is 50% lower than in a patient without induces liver enzymes. More patients with chronic liver disease might therefore be expected to be exposed to NAC treatment than previously. In addition, there is increasing use of NAC in patients with chronic liver disease for multiorgan failure or hepatorenal syndrome. Little is known of NAC's pharmacokinetics properties in patiens with cirrhosis.
Mechanism Of Action And Value Of N-Acetylcysteine In The Treatment Of Early And Late Acetaminophen Poisoning: A Critical Review, Alison Jones
Alison L Jones
Introduction: The mechanism of action of N-acetylcysteine in early acetaminophen poisoning is well understood, but much remains to be learned of the mechanism of its possible benefit in acetaminophen poisoning presenting beyond 15 hours. Methods: Selective review of medical literature. N-acetylcysteine should be used in all cases of early acetaminophen poisoning where the plasma acetaminophen concentration lies “above the line;” which line is chosen depends on individual preference and whether enzyme induction is suspected. Particular care should be taken with the use of the nomogram for patients with chronic excess ingestion of acetaminophen or for those who have taken slow-release …
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Alison L Jones
Since the 1970s, N-acetylcysteine (NAC) has shown proven efficacy as an antidote for acetaminophen (APAP) poisoning and APAP-induced liver failure for early presenters. The current evidence of benefits of NAC for late presenters is controversial because of the poor understanding of the mechanism of late toxicity. In the previous issue of Critical Care, Yang and colleagues use a mouse model to demonstrate that NAC in doses similar to those used therapeutically to treat APAP poisoning in humans impairs liver regenerative capacity and that the effect is more pronounced when administered for a longer duration. Studies based on cell cultures support …
N-Acetylcysteine, Richard Dart, Alison Jones