Open Access. Powered by Scholars. Published by Universities.®
- File Type
Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Paracetamol (Acetaminophen) Overdose, Alison Jones
Paracetamol (Acetaminophen) Overdose, Alison Jones
Alison L Jones
A 23-year-old woman. who is 34 weeks pregnant with her first child, is seen In the Emergency Department after taking 28 paratetamol (500 mg) tablets 2 h ago. She is 62 kg in weight. She did not co-ingest any other drug or alcohol. She complains of nausea and intermittent vomiting. but this has been consistent throughout her pregnancy.
A Young Woman Who Has Taken An Overdose Of Paracetamol (Acetaminophen), Alison Jones
A Young Woman Who Has Taken An Overdose Of Paracetamol (Acetaminophen), Alison Jones
Alison L Jones
No abstract provided.
Mechanism Of Action And Value Of N-Acetylcysteine In The Treatment Of Early And Late Acetaminophen Poisoning: A Critical Review, Alison Jones
Alison L Jones
Introduction: The mechanism of action of N-acetylcysteine in early acetaminophen poisoning is well understood, but much remains to be learned of the mechanism of its possible benefit in acetaminophen poisoning presenting beyond 15 hours. Methods: Selective review of medical literature. N-acetylcysteine should be used in all cases of early acetaminophen poisoning where the plasma acetaminophen concentration lies “above the line;” which line is chosen depends on individual preference and whether enzyme induction is suspected. Particular care should be taken with the use of the nomogram for patients with chronic excess ingestion of acetaminophen or for those who have taken slow-release …
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Prolonged N-Acetylcysteine Therapy In Late Acetaminophen Poisoning Associated With Acute Liver Failure--A Need To Be More Cautious?, T Nimmi, C Athuraliya, Alison Jones
Alison L Jones
Since the 1970s, N-acetylcysteine (NAC) has shown proven efficacy as an antidote for acetaminophen (APAP) poisoning and APAP-induced liver failure for early presenters. The current evidence of benefits of NAC for late presenters is controversial because of the poor understanding of the mechanism of late toxicity. In the previous issue of Critical Care, Yang and colleagues use a mouse model to demonstrate that NAC in doses similar to those used therapeutically to treat APAP poisoning in humans impairs liver regenerative capacity and that the effect is more pronounced when administered for a longer duration. Studies based on cell cultures support …
Paracetamol (Acetaminophen) Poisoning: No Need To Change Current Guidelines To Accident Departments, P Routledge, J Allister Vale, D Nicholas Bateman, G. Denis Johnston, Alison L. Jones, Alan Judd, Simon Thomas, Glyn Volans, L F. Prescott, A T. Proudfoot
Paracetamol (Acetaminophen) Poisoning: No Need To Change Current Guidelines To Accident Departments, P Routledge, J Allister Vale, D Nicholas Bateman, G. Denis Johnston, Alison L. Jones, Alan Judd, Simon Thomas, Glyn Volans, L F. Prescott, A T. Proudfoot
Alison L Jones
Paracetamol is an effective, simple analgesic that is well tolerated by adults and children at therapeutic doses. In many countries it is available without prescription. Unfortunately, its ready availability is associated with episodes of poisoning that prompt 3.3% of inquiries to US regional poisons centres, 10% of inquiries to the UK National Poisons Information Service, and up to 43% of all admissions to hospital with self poisoning in the United Kingdom.3 In the United States paracetamol alone accounted for 4.1% of deaths from poisoning reported to American poisons centres in 1997. Most deaths are associated with deliberate self poisoning, but …