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Zebrafish As A Model For Developmental Neurotoxicity Assessment: The Application Of The Zebrafish In Defining The Effects Of Arsenic, Methylmercury, Or Lead On Early Neurodevelopment, Jinyoung Lee, Jennifer L. Freeman

School of Health Sciences Faculty Publications

Developmental exposure to neurotoxic chemicals presents significant health concerns because of the vulnerability of the developing central nervous system (CNS) and the immature brain barrier. To date, a short list of chemicals including some metals have been identified as known developmental neurotoxicants; however, there are still numerous chemicals that remain to be evaluated for their potential developmental neurotoxicity (DNT). To facilitate evaluation of chemicals for DNT, the zebrafish vertebrate model system has emerged as a promising tool. The zebrafish possesses a number of strengths as a test species in DNT studies including an abundance of embryos developing ex utero presenting …