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Department of Psychological Sciences Faculty Publications
Withdrawal; drinking; acoustic startle; genetics; selected lines
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Acoustic Startle At Baseline And During Acute Alcohol Withdrawal In Replicate Mouse Lines Selectively Bred For High Or Low Alcohol Preference, Julia Chester, Gustavo D. Barrenha
Acoustic Startle At Baseline And During Acute Alcohol Withdrawal In Replicate Mouse Lines Selectively Bred For High Or Low Alcohol Preference, Julia Chester, Gustavo D. Barrenha
Department of Psychological Sciences Faculty Publications
Background: Previous data in both rat and mouse genetic models suggest that there is a genetic relationship between acute alcohol withdrawal responses and innate alcohol drinking behavior. The purpose of the present study was to examine whether acute alcohol withdrawal responses, as measured by acoustic startle and prepulse inhibition (PPI) of acoustic startle, may be genetically related to innate differences in alcohol preference in two mouse lines selectively bred for high (HAP1 and HAP2) or low (LAP1 and LAP2) alcohol preference. Line differences in startle responses at baseline, prior to alcohol or saline treatment, were also measured. Methods: Alcohol-naive, male …