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Do Antidepressants Improve The Quality Of Life And Decrease The Severity Of Symptoms In Patients With Irritable Bowel Syndrome?, Courtney E. Houde
Do Antidepressants Improve The Quality Of Life And Decrease The Severity Of Symptoms In Patients With Irritable Bowel Syndrome?, Courtney E. Houde
PCOM Physician Assistant Studies Student Scholarship
Objective: The objective of this selective EBM review is to determine whether or not the use of antidepressants improves the quality of life and decreases the severity of symptoms in patients with IBS.
Study Design: Review of three English language, double-blind, randomized controlled trials published in 2009.
Data sources: Randomized controlled trials comparing the use of three different antidepressants to a controlled placebo were found on PubMed, OVID and the Cochrane database.
Outcome(s) Measured: Primary end point was overall bowel symptom score at the end of twelve weeks. Secondary end points include individual BSS for each irritable bowel syndrome subset, …