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Full-Text Articles in Medicine and Health Sciences
Repurposing Dextromethorphan And Metformin For Treating Nicotine-Induced Cancer By Directly Targeting Chrna7 To Inhibit Jak2/Stat3/Sox2 Signaling, Lu Wang, Du Liang, Xiao Xiong, Yusheng Lin, Jianlin Zhu, Zhimeng Yao, Shuhong Wang, Yi Guo, Yuping Chen, Kyla Geary, Yunlong Pan, Fuyou Zhou, Shegan Gao, Dianzheng Zhang, Sai-Ching Jim Yeung, Hao Zhang
Repurposing Dextromethorphan And Metformin For Treating Nicotine-Induced Cancer By Directly Targeting Chrna7 To Inhibit Jak2/Stat3/Sox2 Signaling, Lu Wang, Du Liang, Xiao Xiong, Yusheng Lin, Jianlin Zhu, Zhimeng Yao, Shuhong Wang, Yi Guo, Yuping Chen, Kyla Geary, Yunlong Pan, Fuyou Zhou, Shegan Gao, Dianzheng Zhang, Sai-Ching Jim Yeung, Hao Zhang
PCOM Scholarly Papers
Smoking is one of the most impactful lifestyle-related risk factors in many cancer types including esophageal squamous cell carcinoma (ESCC). As the major component of tobacco and e-cigarettes, nicotine is not only responsible for addiction to smoking but also a carcinogen. Here we report that nicotine enhances ESCC cancer malignancy and tumor-initiating capacity by interacting with cholinergic receptor nicotinic alpha 7 subunit (CHRNA7) and subsequently activating the JAK2/STAT3 signaling pathway. We found that aberrant CHRNA7 expression can serve as an independent prognostic factor for ESCC patients. In multiple ESCC mouse models, dextromethorphan and metformin synergistically repressed nicotine-enhanced cancer-initiating cells (CIC) …
The Effects Of Resveratrol On Prostate Cancer Through Targeting The Tumor Microenvironment., Natalie Silk, Jeremy Reich, Rahul Sinha, Shivansh Chawla, Kyla Geary, Dianzheng Zhang
The Effects Of Resveratrol On Prostate Cancer Through Targeting The Tumor Microenvironment., Natalie Silk, Jeremy Reich, Rahul Sinha, Shivansh Chawla, Kyla Geary, Dianzheng Zhang
PCOM Scholarly Papers
Prostate cancer is one of the most common cancers diagnosed in men in the United States and the second leading cause of cancer-related deaths worldwide. Since over 60% of prostate cancer cases occur in men over 65 years of age, and this population will increase steadily in the coming years, prostate cancer will be a major cancer-related burden in the foreseeable future. Accumulating data from more recent research suggest that the tumor microenvironment (TME) plays a previously unrecognized role in every stage of cancer development, including initiation, proliferation, and metastasis. Prostate cancer is not only diagnosed in the late stages …