Medicine and Health Sciences Commons^™

Perinatal Docosahexaenoic Acid Supplementation Improves Cognition And Alters Brain Functional Organization In Piglets., Xi Fang, Wenwu Sun, Julie Jeon, Michael Azain, Holly Kinder, Jeongyoun Ahn, Hee Cheol Chung, Ryan S Mote, Nikolay M Filipov, Qun Zhao, Srujana Rayalam, Hea Jin Park

PCOM Scholarly Papers

Epidemiologic studies associate maternal docosahexaenoic acid (DHA)/DHA-containing seafood intake with enhanced cognitive development; although, it should be noted that interventional trials show inconsistent findings. We examined perinatal DHA supplementation on cognitive performance, brain anatomical and functional organization, and the brain monoamine neurotransmitter status of offspring using a piglet model. Sows were fed a control (CON) or a diet containing DHA (DHA) from late gestation throughout lactation. Piglets underwent an open field test (OFT), an object recognition test (ORT), and magnetic resonance imaging (MRI) to acquire anatomical, diffusion tensor imaging (DTI), and resting-state functional MRI (rs-fMRI) at weaning. Piglets from DHA-fed …

Does The Administration Of Curcumin, Compared To Placebo, Change Cognitive Function In Adults Older Than 40?, Rachel L. Hawkins

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of curcumin, versus a placebo, is effective in changing cognitive function.

STUDY DESIGN: Review of 3 randomized control trials with blinding in English from 2008 to present.

DATA SOURCES: Articles were selected from Cochrane and PubMed databases based on relevance to the selected research question and patient-centered outcomes.

OUTCOME(S) MEASURED: The outcome measured is cognitive change, evaluated by mean score changes in the Mini Mental Status Examination (MMSE) or the Montreal Cognitive Assessment (MoCA).

RESULTS: Two of the studies demonstrated no change in cognitive …