Medicine and Health Sciences Commons^™

The Effects Of Metformin, Aminoguanidine, And Pyridoxamine On Methylglyoxal Induced Cardiac Myocyte Injury, Amanda Harvey, Rose Martorana, Julia Colangeli, Hafsa Ahmed, Dean Delgado, Alisa Kim, Robinderpaul Sandhu, Robert J. Barsotti, Lindon H. Young, Qian Chen

Research Day

Advanced glycation end (AGE) products have been under investigation for their role in cardiovascular disease in complications. Methylglyoxal, a byproduct of glucose metabolism, is elevated in the blood of diabetic patients and has shown to be an important intermediate in the production of AGEs. Due to the highly reactive structure of methylglyoxal, it can produce high levels of reactive oxygen species (ROS) within the cell via mitochondrial modification which results in a loss of cell membrane potential and possible cell death. The role of methylglyoxal in cardiac cells is not well known; in this study methylglyoxal induced cell injury and …