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Identification Of Phytochemicals That Inhibit The Enzymatic Activity Of Sars-Cov-2 3-Chymotrypsin Like Protease (3clpro) In Vitro., Avini Sharma, Anasha Kawall, Devin Lewis, Krishna Chavada, Shashidharamurthy Taval, Vicky Mody, Srujana Rayalam
Identification Of Phytochemicals That Inhibit The Enzymatic Activity Of Sars-Cov-2 3-Chymotrypsin Like Protease (3clpro) In Vitro., Avini Sharma, Anasha Kawall, Devin Lewis, Krishna Chavada, Shashidharamurthy Taval, Vicky Mody, Srujana Rayalam
Research Day
SARS-CoV-2, which emerged in Wuhan, China in December of 2019, is classified as a global pandemic. Several studies suggest that phytochemicals exhibit potent anti-viral effects and in this study, we have investigated the use of phytochemicals as potential anti-SARS-CoV-2 agents. Previous studies indicated the importance of viral proteases in the replication of SARS-CoV-2. Among these proteases, papain-like protease and 3-chymotrypsin-like protease are involved in the synthesis of non-structural proteins responsible for the assembly of the replication-transcription complex. Phytochemicals such as rutin, myricetin, and kaempferol, were reported as potential inhibitors of 3CLpro activity in silico. However, recently we have established that …