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A Correlative Blood Assay To Monitor Patients At Risk For Chemotherapy-Induced Peripheral Neuropathy, Angeleah Dadivas, Kinjal Parikh, John Kennedy, Amy Brady, Margaretha Wallon
A Correlative Blood Assay To Monitor Patients At Risk For Chemotherapy-Induced Peripheral Neuropathy, Angeleah Dadivas, Kinjal Parikh, John Kennedy, Amy Brady, Margaretha Wallon
Research Day
Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of platinum-based chemotherapies like cis-, oxali- and carboplatin. While not all patients experience this effect, those that do are at risk for lifelong neuropathy. Platinum-based therapies cause bursts of reactive oxygen species (ROS), which can trigger structural changes in peripheral nerves including neuronopathy, axonopathy and/or myelinopathy. Glutathione, an antioxidant, plays an important role in redox homeostasis. The recycling of glutathione can be determined by the ChemoTox assay and the aim of this study was to examine its ability to predict CIPN.
Methods: Blood drawn from consented and chemotherapy …