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Full-Text Articles in Medicine and Health Sciences
Pilot Study Of Symptom Burden And Quality Of Life Among Families Of Children In Palliative Care Or Hospice, Marci Z. Fults, Samantha Manring, Sarah Snyder, Mary Jo Gilmer, Michelle Walsh, Janine Winters, Cynthia A. Gerhardt
Pilot Study Of Symptom Burden And Quality Of Life Among Families Of Children In Palliative Care Or Hospice, Marci Z. Fults, Samantha Manring, Sarah Snyder, Mary Jo Gilmer, Michelle Walsh, Janine Winters, Cynthia A. Gerhardt
Research Day
Purpose: Despite calls for improvement in pediatric palliative care, children may have significant suffering at end-of-life (EOL). Research is limited and relies heavily on retrospective reports from mothers or nurses. We prospectively assessed symptom burden and quality of life (QOL) among children with life limiting conditions to examine concordance across multiple informants (i.e., mother, father, child, nurse). Method: Families were recruited shortly after their child (ages 5-18) was enrolled in palliative care or hospice. Of 36 eligible families, 8 children died before recruitment. Of the remaining 28, 25 (89%) participated. Participants included 25 mothers, 14 fathers, 12 children (Mage = …
Chikungunya Occurrence Among A Religious Missions Trip To Haiti In The Summer Of 2014 And Implications For Community Health, Veronica Williams, Jared Rutledge, Heather Brewer
Chikungunya Occurrence Among A Religious Missions Trip To Haiti In The Summer Of 2014 And Implications For Community Health, Veronica Williams, Jared Rutledge, Heather Brewer
Research Day
As global travel becomes more common, the risk of spreading infectious diseases is increasing. Vectors too are spreading and becoming invasive species in environmental niches where they had previously been absent. The potential continues to grow for people to bring back diseases and infect local naive insect populations, which over time will increase the likelihood of the disease transmission occurring locally. This article evaluates the impact of a mission’s trip to Haiti and the return to a region of the United States that just recently became invaded by Aedes aegypti. The attack rate among the missionaries was approximately 20% (n=2), …
Comparing Two Different Intravenous Regimens Of Tranexamic Acid In Total Hip Arthroplasty, Total Knee Arthroplasty, And Total Shoulder Arthroplasty, Mark Church, Myron Szczukowski Jr., Richard Mason, Laura Hanlon, Thomas Sisca
Comparing Two Different Intravenous Regimens Of Tranexamic Acid In Total Hip Arthroplasty, Total Knee Arthroplasty, And Total Shoulder Arthroplasty, Mark Church, Myron Szczukowski Jr., Richard Mason, Laura Hanlon, Thomas Sisca
Research Day
One significant intraoperative outcome of concern to anesthesiologists and orthopedic surgeons is controlling the amount of blood loss both intraoperatively and postoperatively. The use of the antifibrinolytic, tranexamic acid (TXA), is an innovative strategy that has been shown to decrease postoperative bleeding as well as decrease the need for blood transfusions. Currently, there are multiple intravenous tranexamic acid dose regimens that are being employed for orthopedic surgeries. In this study, the aim was to evaluate the effectiveness of a 2 dose regimen (1000 mg within 30 minutes pre-op and 1000 mg 4-6 hrs post-op) compared to a single 1000 mg …
The Effects Of Modulating Endothelial Nitric Oxide Synthase (Enos) Activity And Coupling In Coronary, Hindlimb, Renal, And Mesenteric Vascular Inflammation Models, Alexandra Lopez, Kerry-Anne Perkins, Amber Koon, Amelie Bottex, Qian Chen, Robert Barsotti, Lindon Young
The Effects Of Modulating Endothelial Nitric Oxide Synthase (Enos) Activity And Coupling In Coronary, Hindlimb, Renal, And Mesenteric Vascular Inflammation Models, Alexandra Lopez, Kerry-Anne Perkins, Amber Koon, Amelie Bottex, Qian Chen, Robert Barsotti, Lindon Young
Research Day
Ischemia/reperfusion (I/R) injury is initiated in part by vascular endothelial dysfunction, which is characterized by reduced endothelial-derived nitric oxide (NO) and/or increased oxidative stress, followed by inflammation. When the tetrahydrobiopterin (BH4) to dihydrobiopterin (BH2, oxidized form of BH4) ratio is reduced, eNOS can become uncoupled shifting production of NO to superoxide (SO). Protein kinase C epsilon activator (PKCε+) enhances eNOS activity while PKCε inhibitor (PKCε-) reduces eNOS activity. The effects of PKCε+ or PKCε- combined with BH4 or BH2 were studied in rat myocardial and hindlimb I/R, rat renal lithotripsy, and rat mesenteric inflammation models. Promoting eNOS coupling using PKCε+ …
Astrocytes Infected With Chlamydia Pneumonia Alter Amyloid Processing Implicated In Alzheimer’S Disease, Zein Al-Atrache, Ahmad Cader, Susan Hingley, Denah Appelt
Astrocytes Infected With Chlamydia Pneumonia Alter Amyloid Processing Implicated In Alzheimer’S Disease, Zein Al-Atrache, Ahmad Cader, Susan Hingley, Denah Appelt
Research Day
Alzheimer’s Disease (AD) is a chronic, progressive neurodegenerative disease whose pathogenesis centers around the abnormal processing of amyloid precursor protein (APP) by proteases, resulting in the formation of neuritic plaques composed of toxic, insoluble fragments of amyloid protein (Aβ), including Aβ1-40 and Aβ1-42. Previously, our laboratory identified Chlamydia pneumoniae (Cpn) in autopsied sporadic AD brains. Additionally, an infection based animal model was developed using BALB/c mice that were intranasally inoculated with Cpn, in which the deposition of amyloid was consistent with that observed in the human AD brain. These studies have led to the pathogen hypothesis of AD that implicates …
Blood Pressure Vs Altitude In Hypertensive And Non-Hypertensive Himalayan Trekkers, T. Douglas Sallade, Jennifer Starling, David Young, David Twillman, Nirakan Regmi, Benoit Phelan, Purshotam Paudel, Sushil Pant, Matthew Mcelwee, Theodore Mcconnell, Luke Mather, Charles Duke
Blood Pressure Vs Altitude In Hypertensive And Non-Hypertensive Himalayan Trekkers, T. Douglas Sallade, Jennifer Starling, David Young, David Twillman, Nirakan Regmi, Benoit Phelan, Purshotam Paudel, Sushil Pant, Matthew Mcelwee, Theodore Mcconnell, Luke Mather, Charles Duke
Research Day
Introduction: Determine blood pressure (BP) response to changes in altitude in Himalayan trekkers with and without hypertension (HTN). Methods: BP was measured in Lukla (2800m), Namche (3400m), and either Pheriche or Dingboche (4400m) on ascent and descent. Hypertensive subjects were defined by self-reported diagnosis of HTN. Results: Trekkers had HTN (H, n=60) or no HTN (NH, n=604). Of those with HTN, 50 (83%) took one or more BP medications including ACEIs/ARBs (n=35, 48%), Ca++ channel blockers (n=15, 22%), beta-blockers (n=9, 13%), thiazide diuretics (n=7, 10%), and others (n=5, 7%). At 2800m, systolic BP (SBP) and diastolic BP (DBP) were greater …
Get The Right Fit: Strategies For Making Your Work More Visible, Stephanie Ferretti, Richard James, Skye Bickett
Get The Right Fit: Strategies For Making Your Work More Visible, Stephanie Ferretti, Richard James, Skye Bickett
Research Day
Supporting research is one of the core missions of the PCOM Library, and “publish or perish” is still a central concern for faculty even with the fundamental transformation underway in the scholarly publishing industry. The PCOM Library wants to help you understand how these changes impact your research work.Here are some resources and ideas that can assist faculty, staff, and students with communicating your research and expanding its audience .Learn more about Selected Works faculty pages and how the library can enhance your scholarly works.
Dust-Off The Ecmo, My Patient Just Inhaled 1,1-Difluoroethane, Robert A. Bassett, Michael Kowalski, William J. Borough, Steven J. Walsh
Dust-Off The Ecmo, My Patient Just Inhaled 1,1-Difluoroethane, Robert A. Bassett, Michael Kowalski, William J. Borough, Steven J. Walsh
Research Day
Dust-Off® computer cleaner containing 1,1-difluoroethane (DFE) is frequently cited in cases of inhalation abuse. Malignant cardiac dysrhythmias are a well-recognized complication of DFE toxicity. We describe a patient with prolonged ventricular irritability following DFE inhalation, who was successfully treated with a central α-2 agonist and extracorporeal membrane oxygenation (ECMO).
The Sto2 Non-Invasive Tissue Hypoperfusion Monitor As A Screening Tool For Early Sepsis Detection In The Emergency Department, Zachary Kopelman, James Zhou, Alexandra Dattilo, Sandra Schneider, Mary Frances Ward, John D'Angelo, Jason D'Amore
The Sto2 Non-Invasive Tissue Hypoperfusion Monitor As A Screening Tool For Early Sepsis Detection In The Emergency Department, Zachary Kopelman, James Zhou, Alexandra Dattilo, Sandra Schneider, Mary Frances Ward, John D'Angelo, Jason D'Amore
Research Day
Background: Early Recognition of patients with sepsis induced tissue hypoperfusion (SITH) Remains a significant clinical challenge. Non--‐invasive Tissue oxygenation saturation (StO2) Monitors have been developed to provide rapid, low--‐cost, and non--‐invasive bedside assessments of tissue oxygen extraction; they have not been well validated as an initial screening tool for sepsis in the ED. Objectives: To Assess the efficacy of initial bedside StO2 Readings in the early identification of patients with SITH And to compare StO2 Readings with lactate levels. Methods: IRB approved, prospective, observational pilot study of a convenience sample of ED Patients presenting with a sepsis continuum diagnosis. Setting: …
Review Of The Use Of Ceritinib, A Newly Approved Anaplastic Lymphoma Kinase (Alk) Inhibitor, In Crizotinib-Resistant Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer, Sonia Thomas, Afua Gyapong, Nathan Greenfield
Review Of The Use Of Ceritinib, A Newly Approved Anaplastic Lymphoma Kinase (Alk) Inhibitor, In Crizotinib-Resistant Anaplastic Lymphoma Kinase-Rearranged Non-Small Cell Lung Cancer, Sonia Thomas, Afua Gyapong, Nathan Greenfield
Research Day
Lung cancer is one of the most prevalent cancers in the United States, and is the leading cause of death related to cancer. Non-small cell lung cancer is the most common subtype, with approximately 85% of diagnosed lung cancer being non-small cell lung cancer. Several genetic mutations exist in patients with non-small cell lung cancer, which allows for specialized targeted therapy. One such mutation, EML4-ALK fusion protein abnormalities, represents roughly 5% of non-small cell lung cancer patients, but the patient population in which it is most prevalent is young adults and those that don’t smoke or have a short history …
Evaluation Of Liposomal Bupivacaine Versus Immediate Release Bupivacaine In Post-Operative Pain After Knee Surgery, Nathan Greenfield, Saba Gidey, Dusty Lisi, Cristina Refec
Evaluation Of Liposomal Bupivacaine Versus Immediate Release Bupivacaine In Post-Operative Pain After Knee Surgery, Nathan Greenfield, Saba Gidey, Dusty Lisi, Cristina Refec
Research Day
Purpose: The use of liposomal bupivacaine, which is formulated to have an extended release, has been associated with a decrease in opiate use after total hip and knee arthroplasty. The aim of this retrospective study is to compare the use of liposomal bupivacaine and immediate release bupivacaine in patients who have undergone knee replacement. The purpose of this study is to determine the effectiveness of using liposomal bupivacaine for patients undergoing total knee arthroplasty in comparison to current practice. Methods This is a single-center, retrospective, cohort study that is being conducted in a 353 bed academic medical center. The electronic …