Medicine and Health Sciences Commons^™

Ponatinib-Induced Adverse Effects: Thrombocytopenia, Pancreatitis And Hepatoxicity-- A Case Report, Saba Hasan, Crystal Fedorkiv, Naba Rahman, Jennifer Andres

Research Day

Abstract: Chronic myeloid leukemia (CML) is a myeloproliferative disease that generates from malignant transformation of pluripotent hematopoietic stem cells. First line treatment for CML is the tyrosine kinase inhibitor (TKI), imatinib. For patients resistant or intolerant to imatinib, other TKIs, dasatinib, nilotinib, and ponatinib, are approved treatments. Patients who are resistant or intolerant to other agents are started on ponatinib as a last line option. Common adverse events of ponatinib are hypertension, dry skin, rash, abdominal pain, constipation, and nausea. More serious adverse effects include cardiovascular effects, fluid retention, pancreatitis, severe myelosuppression, and hepatotoxicity. Treatment for these adverse effects can …

Anterior Cervical Foraminotomy: Short Term Outcomes In Patients With Isolated Cervical Radiculopathy, Howard Eisenbrock, Mark Rivkin, Amir R. Dehdashti

Research Day

Intro: Anterior cervical foraminotomy (ACF) is a novel approach involving direct decompression of nerve from an offending agent without fusion. Historically, several anterior and posterior approaches were utilized to treat cervical radiculopathy. Anterior cervical discectomy necessitates fusion and is subject to adjacent segment disease as well as loss of ROM. Posterior laminoforaminotomy seldom allows for removal of disc fragment and is associated with higher postoperative pain.

Methods: Between May 2010 and March 2013, 16 patients with one or two level cervical spondylosis with radiculopathy without myelopathy who failed conservative therapies such as anti-inflammatory medications, physical therapy or injections underwent anterior …

Kyphotic Progression After Thoracolumbar Burst Fractures Treated Conservatively, With Mis, Or Via Open Approach, Mark Rivkin, Howard Eisenbrock

Research Day

Management of thoracolumbar burst fractures (AO A3) without neurological deficit is subject to debate in the literature. While TLICS provides guidance for injuries necessitating intervention, it makes little mention of best surgical approaches. Furthermore, intact patients with suspected posterior ligamentous complex injury (TLICS 4) compose an additional level of management uncertainty. Present study examined outcomes for TL burst fractures in neurologically intact patients with suspected disruption of the PLC treated with bracing, MIS, or open fixation and fusion.

Social Problem-Solving Orientation And Ptsd Symptoms In Adults With Lqts Who Experienced Cardiac Events, Elizabeth A. Waldron, Stephanie H. Felgoise, Katherine L. Corvi

Research Day

Long QT Syndrome (LQTS) is a genetic condition affecting 1:2500, predisposing individuals to cardiac arrhythmias (Ellis et al., 2009). Life threatening symptoms are unpredictable though physical exertion, emotional upset, and sleep are known triggers. Severity of symptoms and psychological factors predict development of PTSD symptoms for other cardiac diseases (Whitehead et al., 2006). Effects of LQTS-related events have not been studied. Individuals with PTSD show poorer problem solving compared to those without PTSD (Sutherland & Bryant, 2008). Problem orientation is comprised of the cognitive-emotional schemas reflective of the approaches towards problem-solving ability, general life appraisals, and beliefs (D’Zurilla et al., …

Nutri One-On-One: Improving Patients’ Metabolic Profile With One-On-One Nutritional Coaching, Jennifer King, Jeffrey E. Harris, David Kuo, Farzaneh Daghigh

Research Day

Introduction: More than one-third of U.S. adults (35.7%) are obese. Some of the leading causes of death are due to complications of chronic conditions related to metabolic disorders and obesity. One on one health coaching will assist people in adopting healthy lifestyle behaviors that prevent and control diseases through phases of effective goal setting, motivational interviewing, and collaboration with health care providers.

Objectives: This study’s aim was to positively influence patients’ nutritional habits and lifestyle through a brief one on one coaching session. The effects of one on one nutritional education are analyzed through goal setting, motivational lessons, and follow-up …

Phytochemicals Added To The Feed Of Ovariectomized Adult Rats Increase Brown Adipose Activity, Colette N. Miller, Suresh Ambati, Erica Bass, Natalie Hohos, Diane Hartzel, Emily England, Mary Anne Della-Fera, Srujana Rayalam, Clifton A. Baile

Research Day

Background: Brown adipose tissue (BAT) uncouples respiration, using lipids as an energy source while dissipating heat. Increases in BAT activity are protective against obesity, thus compounds that increase BAT activation may help prevent weight gain. Resveratrol (R) increases BAT activity by upregulating thermogenic genes. As phytochemicals have synergistic properties, our research strategy has included investigation of the efficacy of relatively low concentrations of phytochemical blends on BAT activation. Methods: Previously, we showed that R combined with genistein (G) and quercetin (Q) reduced weight gain in aged ovariectomized (OVX) female rats. In the current study, OVX rats were fed diets containing …

Get The Right Fit: Strategies For Navigating Author Rights And Access, Skye Bickett, Stephanie Ferretti

Research Day

Supporting research at PCOM is one of the core missions of the PCOM Library. Librarians have been leaders in the movement for expanded sharing of scholarship. Scholarly publishing is undergoing fundamental transformations and the PCOM Library wants to help you understand how these changes impact your scholarly endeavors. Here are some resources and ideas that can assist faculty, staff, and students with scholarly publishing and data management.

Modeling Mglur1 Mediated Synaptic Depression In Cerebellar Purkinje Cells, Yizhen Su, Huo Lu

Research Day

In our previous study, we have successfully simulated mGluR1 mediated sEPSP based on experimental and is associated with parallel fiber – Purkinje cell LTD [1, 2, 3]. Recent studies have shown that the mGluR1 mediated sEPSP is generated by calcium signaling through the TRPC channel which is crucial in cerebellar LTD induction [4]. Behavior study using mutant mice that lack this type of LTD has shown no motor learning impairment [5]. We hypothesize that cerebellar TRPC mediated synaptic depression shifts the excitatory and inhibitory balance to down regulate ongoing simple-spike activity. To test our hypothesis we modified our previous model …

Effectiveness Of Multiple Recruitment Strategies For A Large Clinical Trial With Learner Teen Drivers, Julia Lockyer, Megan Fisher-Thiel, Allison Curry, Jessica Mirman, Flaura Winston, James Massey, Dennis Durbin

Research Day

Many studies do not achieve their goal for participant enrollment (Mapstone, Elbourne, & Roberts, 2002).

• Longitudinal studies with teen drivers are rare, in part due to the difficulty with recruitment and attrition as well as necessarily strict inclusion criteria (Lee et al., 2011; McCartt, Farmer, 7 Jenness, 2010).• The sources used for recruitment can be a determining factor in the effectiveness of the overall enrollment rates.

• A community-based randomized controlled trial required recruitment of a large number of participants, 512 parent-teen dyads, in a short period of time. This is a post-hoc analysis of the most effective forms …

Gp91ds-Tat, A Selective Nadph Oxidase Peptide Inhibitor, Increases Blood Nitric Oxide (No) Bioavailability In Bind Limb Ischemia And Reperfusion (I/R), Sydney Walker, Tyler Galbreath, Qian Chen, Robert J. Barsotti, H. Patel, William Chau, Lindon H. Young

Research Day

I/R injury induces cell death and organ dysfunction in part due to a burst of reactive oxygen species that occurs upon the reintroduction of oxygen into the ischemic area, leading to endothelial dysfunction: decreased blood NO and increased hydrogen peroxide (H2O2 ) levels. We’ve previously shown in isolated rat hearts subjected to I/R injury, gp91ds-tat attenuated cardiac contractile dysfunction and reduced infarct size compared to controls presumably by the inhibition of NADPH oxidase induced superoxide release. Superoxide can quench NO via the formation of peroxynitrite and also be converted to H2O2 in blood. We attempted to confirm this hypothesis using …

Mitoquinone (Mitoq) Exerts Antioxidant Effects Independent Of Mitochondrial Targeted Effects In Phorbol-12-Myristate-13-Acetate (Pma) Or N-Formyl-L-Methiony-L-Leucyl-L-Phenylalanine (Fmlp) Stimulated Polymorphonuclear Leukocyte (Pmn) Superoxide (So) Release, Matthew Lepera, D. Pesikan, J. Voeun, Kerry-Anne Perkins, Qian Chen, Robert J. Barsotti, Lindon H. Young

Research Day

MitoQ is a mitochondrial-targeted coenzyme Q antioxidant analog that dose-dependently restored cardiac function and reduced infarct size in isolated perfused rat hearts subjected to ischemia reperfusion (I/R). Moreover, mitoQ also dose-dependently attenuated PMA stimulated PMN superoxide (SO) release at the same concentration (10uM) as the cardioprotective dose. NADPH oxidase is the principle source of PMN SO release. We speculate that mitoQ may exert antioxidant effects independent of the mitochondria. Therefore, we hypothesized that inhibition of mitoQ on PMN-SO release will be similar as other coenzyme Q analogs: coenzyme Q1 and decylubiquinone without affecting cell viability. SO release was measured spectrophotometrically …

Insulin Pump Class: Back To The Basics Of Pump Therapy, Sara Wilson Reece, Cheryl Williams

Research Day

Insulin pump therapy is a common mechanism for insulin delivery in Type 1 diabetes mellitus as well as in some patients with Type 2 diabetes mellitus. At the Longstreet Clinic, approximately 3% of patients on insulin therapy utilize insulin pumps. After several patients on insulin pump therapy experienced severe hypoglycemic episodes while driving, the need for review of insulin pump survival skills were identified. The insulin pump class which was conducted in a small group setting reviewed all of the necessary survival skills for effective insulin pump therapy. Pre- and post-class hemoglobin A1c values and emergency room visits as well …