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Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
"A Cage Of Ovulating Females" : Mary Breckinridge And The Politics Of Contraception In Rural Appalachia, Dana Allen Johnson
"A Cage Of Ovulating Females" : Mary Breckinridge And The Politics Of Contraception In Rural Appalachia, Dana Allen Johnson
Theses, Dissertations and Capstones
Mary Breckinridge and the Frontier Nursing Service have been the focus of intense scholarly effort over the last twenty years. Scholarship on Mary Breckinridge has centered on her healthcare reform work in Appalachia and its effects on the local residents and culture. This thesis examines the oral contraceptive trial that the FNS performed in Leslie County in the late 1950s and early 1960s. Although Breckinridge and the FNS maintained a restrictive contraceptive stance, they paradoxically permitted the contraceptive trial to be conducted on their patients in Leslie County. The decision to participate in the contraceptive trial resulted from a complex …
Antibiotic Sensitivity Patterns Of Hospital-Acquired And Community-Acquired Methicillin Resistant Staphylococcus Aureus, Iyad Kaddora
Antibiotic Sensitivity Patterns Of Hospital-Acquired And Community-Acquired Methicillin Resistant Staphylococcus Aureus, Iyad Kaddora
Theses, Dissertations and Capstones
Staphylococcus aureus is one of the most dangerous human pathogens. An intensive effort to control resistant staphylococci, especially methicillin resistant Staphylococcus aureus (MRSA), is vital as it is the most common cause of hospitalacquired infections. During the one year study period, a total of 35 MRSA isolates were collected. Fifteen isolates were identified as hospital-acquired (HA) infections, and 20 isolates were determined to be community acquired (CA). All 15 (100%) HA-MRSA strains were resistant to clindamycin and to erythromycin. Thirteen isolates (87%) were resistant to ciprofloxacin and levofloxacin, and 12 (80%) were resistant to moxifloxacin. Of the 20 CA-MRSA isolates, …
Treatment Strategies In Acute Myelogenous Leukemia : Investigating Hsp90 And P53 As Targets, Jennifer M. Napper
Treatment Strategies In Acute Myelogenous Leukemia : Investigating Hsp90 And P53 As Targets, Jennifer M. Napper
Theses, Dissertations and Capstones
Acute myelogenous leukemia (AML) is the deadliest of the lymphatic and bone marrow cancers. Patients diagnosed with AML have a five year survival rate of 23.4%. AML is characterized by an accumulation of undifferentiated and functionless myeloid precursors in the bone marrow and blood. Heat shock protein 90 (Hsp90) inhibitors, such as 17-AAG, an analog of geldanamycin (GM), are currently undergoing phase I, and II and III clinical trials for various cancers with mixed results. I found distinct responses to 17-AAG treatment among the AML cell lines tested. I also discovered two mutant TP53 alleles in Kasumi-3 cells, an AML …
Age- And Sex-Associated Changes In Mrna Expression Of Neurodegenerative Disorder-Related Molecules In The Hippocampus And Cerebellum Of Rat Brain, Srinivasarao Thulluri
Age- And Sex-Associated Changes In Mrna Expression Of Neurodegenerative Disorder-Related Molecules In The Hippocampus And Cerebellum Of Rat Brain, Srinivasarao Thulluri
Theses, Dissertations and Capstones
Age-associated oxidative stress is involved in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, and sex-associated differences may also affect the risk for these neurodegenerative diseases. We compared the effects of aging and sex on the mRNA expression of five molecules that are closely related to oxidative stress, along with Alzheimer’s and Parkinson’s diseases in the hippocampus of both male and female Fischer 344xBrown Norway (F344BN) rats. The reverse transcription polymerase chain reaction was used to determine the mRNA expression level of superoxide dismutase 2 (SOD2), heme oxygenase 1 (HO1), amyloid precursor protein (APP), -site APP-cleaving enzyme 1 (BACE1), and …
Genetic And Environmental Factors Suggest That Dietary Fatty Acid Content, Lipid Metabolism, And Bone Properties Are Key Regulators Of Myeloid Progenitor Cell Frequency, Melinda E. Varney
Genetic And Environmental Factors Suggest That Dietary Fatty Acid Content, Lipid Metabolism, And Bone Properties Are Key Regulators Of Myeloid Progenitor Cell Frequency, Melinda E. Varney
Theses, Dissertations and Capstones
Acute myelogenous leukemia (AML) and its precursors are the result of the dysregulation of hematopoiesis. Hematopoiesis proceeds in a stepwise manner, beginning with hematopoietic stem cells, continuing to develop into various stages of progenitor cells, and finally becoming fully functional blood cells. As this process goes awry, immature, functionless cells of the myeloid lineage proliferate out of control. Discerning how myeloid progenitor frequency is regulated allows for a better understanding of how the process may lose control. Hematopoiesis has been shown to depend on genetic and environmental factors. In this work, I have added to this knowledge base by providing …
Modeling Super-Spreading Events For Sars, Thembinkosi P. Mkhatshwa
Modeling Super-Spreading Events For Sars, Thembinkosi P. Mkhatshwa
Theses, Dissertations and Capstones
One of the intriguing characteristics of the 2003 severe acute respiratory syndrome (SARS) epidemics was the occurrence of super spreading events (SSEs). Super-spreading events for a specific infectious disease occur when infected individuals infect more than the average number of secondary cases. The understanding of these SSEs is critical to under- standing the spread of SARS. In this thesis, we present a modification of the basic SIR (Susceptible - Infected - Removed) disease model, an SIPR (Susceptible - Regular Infected - Super-spreader - Removed) model, which captures the effect of the SSEs.
An Initial Investigation Of The Applicability Of The Dreyfus Skill Acquisition Model To The Professional Development Of Nurse Educators, Lisa Ramsburg
An Initial Investigation Of The Applicability Of The Dreyfus Skill Acquisition Model To The Professional Development Of Nurse Educators, Lisa Ramsburg
Theses, Dissertations and Capstones
Little is known about the skill and knowledge acquisition of nurses in the educator role. This investigation represents an attempt to design and validate a skill acquisition model for the nurse educator role. While nurse educators often have strong clinical backgrounds, they face a significant role transition as nurse educators. Dreyfus and Dreyfus provided a model for studying skill acquisition in several fields and Benner applied the model to clinical nursing. To investigate skill acquisition among nurse educators, the Dreyfus Model of Skill Acquisition along with the National League for Nursing (NLN) Nurse Educator Competencies provided a framework for the …
The Medicalization Of Hyperactivity And Inattentiveness : A Social History And Theoretical Perspectives On Adhd, Justin Douglas Brock
The Medicalization Of Hyperactivity And Inattentiveness : A Social History And Theoretical Perspectives On Adhd, Justin Douglas Brock
Theses, Dissertations and Capstones
This study investigates the rise of the Attention-Deficit/Hyperactivity Disorder diagnosis. It approaches the topic from a medicalization perspective and frames it under the therapeutic state as proposed by Nicholas Kittrie in 1971. It asks three questions: how has society, and particularly, the medical community changed to allow the medicalization of hyperactivity and social control of active children? How has the continuing diagnosis of hyperactivity in children expanded to include attention deficit hyperactivity disorder in both children and adults? And what forces are behind the continuously inclusive diagnosis and why? In an attempt to answer these questions the history of the …
The Expression And Function Of Hypoxia Inducible Factor-1Α In Human Melanoma, Sandeep S. Joshi
The Expression And Function Of Hypoxia Inducible Factor-1Α In Human Melanoma, Sandeep S. Joshi
Theses, Dissertations and Capstones
Hypoxia inducible factor-1α (HIF-1α) protein, a key regulator of oxygen homeostasis, is stabilized under hypoxia and degraded under normal oxygen tension. Here, the human melanoma cells were found to express an elevated amount of HIF-1α mRNA and protein relative to normal human melanocytes under normoxic conditions. The amount of HIF-1α expressed is roughly correlated with the stage of melanoma from which the cell line was established. In addition, a splice variant mRNA of HIF-1α785 is expressed at higher levels than full-length HIF-1α mRNA in the more aggressive melanoma cells. This splice variant lacks part of the oxygen regulation domain. Ectopic …