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Immunohistochemical Expression Of Tlr-4 In Temporomandibular Joint Dysfunction, Luis Eduardo Almeida, Kyle Hresko, Adam Sorenson, Seth Butcher, Lobat Tayebi, Rosalia Leonardi, Carla Loreto, Jose A. Bosio, Flavio Camejo, Andrea Doetzer

School of Dentistry Faculty Research and Publications

Objective

Toll-like receptor 4 (TLR-4) is a transmembrane protein involved in the innate immune system and has been implicated in the pathogenesis of temporomandibular joint dysfunction (TMD). The purpose of this study was to histologically examine the level of expression of TLR-4 relative to severity of TMD.

Methods

Thirty-one human TMJ disc samples were immunostained for TLR-4 and evaluated for intensity of stain. Among the samples, 8 were control samples, 16 were from patients with anterior disc displacement with reduction (ADDwR), and 7 were from patients with anterior disc displacement without reduction (ADDwoR).

Results

There was no statistically significant difference …

Immunohistochemical Analysis Of Il-1 Receptor 1 In The Discs Of Patients With Temporomandibular Joint Dysfunction, Luis Eduardo Almeida, Adam Sorenson, Kyle Hresko, Seth Butcher, Rosalia Leonardi, Carla Lorento, Jose A. Bosio, Lobat Tayebi, Andrea Doetzer

School of Dentistry Faculty Research and Publications

Objective

Temporomandibular joint dysfunction (TMD) may affect a patient’s quality of life, and one of the etiologies can be anterior disc displacement with reduction (ADDwR) and anterior disc displacement without reduction (ADDWoR). Interleukin 1 Receptor 1 (IL-1R1) is a membrane receptor that plays an important role on initiating immune and inflammatory response by binding the agonists ligands of IL-1 alpha and IL-1 beta. Therefore, the aim of this study was to evaluate, through immunohistochemical analysis, the association of IL-1R1 with TMD.

Methods

Thirty-nine human disc samples were collected and composed three different groups: ADDwR (n = 19), ADDwoR ( …