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Full-Text Articles in Medicine and Health Sciences
Site-Specific Effects On Respiratory Rhythm And Pattern Of Ibotenic Acid Injections In The Pontine Respiratory Group Of Goats, Joshua M. Bonis, Suzanne Neumueller, Katie L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert Forster
Site-Specific Effects On Respiratory Rhythm And Pattern Of Ibotenic Acid Injections In The Pontine Respiratory Group Of Goats, Joshua M. Bonis, Suzanne Neumueller, Katie L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert Forster
Physical Therapy Faculty Research and Publications
To probe further the contributions of the rostral pons to eupneic respiratory rhythm and pattern, we tested the hypothesis that ibotenic acid (IA) injections in the pontine respiratory group (PRG) would disrupt eupneic respiratory rhythm and pattern in a site- and state-specific manner. In 15 goats, cannulas were bilaterally implanted into the rostral pontine tegmental nuclei (RPTN; n = 3), the lateral (LPBN; n = 4) or medial parabrachial nuclei (MPBN; n = 4), or the Kölliker-Fuse nucleus (KFN; n = 4). After recovery from surgery, 1- and 10-μl injections (1 wk apart) of IA were made bilaterally through the …
The Pontine Respiratory Group, Particularly The Kölliker-Fuse Nucleus, Mediates Phases Of The Hypoxic Ventilatory Response In Unanesthetized Goats, Joshua M. Bonis, Suzanne E. Neumueller, K. L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert V. Forster
The Pontine Respiratory Group, Particularly The Kölliker-Fuse Nucleus, Mediates Phases Of The Hypoxic Ventilatory Response In Unanesthetized Goats, Joshua M. Bonis, Suzanne E. Neumueller, K. L. Krause, T. Kiner, A. Smith, B. D. Marshall, B. Qian, Lawrence Pan, Hubert V. Forster
Physical Therapy Faculty Research and Publications
The objective of the present study was to test the hypothesis that, in the in vivo awake goat model, perturbation/lesion in the pontine respiratory group (PRG) would decrease the sensitivity to hypercapnia and hypoxia. The study reported herein was part of two larger studies in which cholinergic modulation in the PRG was attenuated by microdialysis of atropine and subsequently ibotenic acid injections neurotoxically lesioned the PRG. In 14 goats, cannula were bilaterally implanted into either the lateral (n = 4) or medial (n = 4) parabrachial nuclei or the Kölliker-Fuse nucleus (KFN, n = 6). Before and after …