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Full-Text Articles in Medicine and Health Sciences
Antagonism Of Gaba-B But Not Gaba-A Receptors In The Vta Prevents Stress- And Intra-Vta Crf-Induced Reinstatement Of Extinguished Cocaine Seeking In Rats, Jordan M. Blacktop, Oliver Vranjkovic, Matthieu Mayer, Matthew Van Hoof, David A. Baker, John R. Mantsch
Antagonism Of Gaba-B But Not Gaba-A Receptors In The Vta Prevents Stress- And Intra-Vta Crf-Induced Reinstatement Of Extinguished Cocaine Seeking In Rats, Jordan M. Blacktop, Oliver Vranjkovic, Matthieu Mayer, Matthew Van Hoof, David A. Baker, John R. Mantsch
Biomedical Sciences Faculty Research and Publications
Stress-induced reinstatement of cocaine seeking requires corticotropin releasing factor (CRF) actions in the ventral tegmental area (VTA). However the mechanisms through which CRF regulates VTA function to promote cocaine use are not fully understood. Here we examined the role of GABAergic neurotransmission in the VTA mediated by GABA-A or GABA-B receptors in the reinstatement of extinguished cocaine seeking by a stressor, uncontrollable intermittent footshock, or bilateral intra-VTA administration of CRF. Rats underwent repeated daily cocaine self-administration (1.0 mg/kg/ing; 14 × 6 h/day) and extinction and were tested for reinstatement in response to footshock (0.5 mA, 0.5” duration, average every 40 …
Cb1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement Of Cocaine Seeking In Rats, Jayme R. Mcreynolds, Elizabeth M. Doncheck, Oliver Vranjkovic, Geoffrey S. Ganzman, David A. Baker, Cecilia J. Hillard, John R. Mantsch
Cb1 Receptor Antagonism Blocks Stress-Potentiated Reinstatement Of Cocaine Seeking In Rats, Jayme R. Mcreynolds, Elizabeth M. Doncheck, Oliver Vranjkovic, Geoffrey S. Ganzman, David A. Baker, Cecilia J. Hillard, John R. Mantsch
Biomedical Sciences Faculty Research and Publications
Rationale
Under some conditions, stress, rather than directly triggering cocaine seeking, potentiates reinstatement to other stimuli, including a subthreshold cocaine dose. The mechanisms responsible for stress-potentiated reinstatement are not well defined. Endocannabinoid signaling is increased by stress and regulates synaptic transmission in brain regions implicated in motivated behavior.
Objectives
The objective of this study was to test the hypothesis that cannabinoid type 1 receptor (CB1R) signaling is required for stress-potentiated reinstatement of cocaine seeking in rats.
Methods
Following i.v. cocaine self-administration (2 h access/day) and extinction in male rats, footshock stress alone does not reinstate cocaine seeking but reinstatement is …