Medicine and Health Sciences Commons^™

Critical-Sized Bone Defects Regeneration Using A Bone-Inspired 3d Bilayer Collagen Membrane In Combination With Leukocyte And Platelet-Rich Fibrin Membrane (L-Prf): An In Vivo Study, Farahnaz Fahimipour, Farshid Bastami, Ahad Khoshzaban, Shahrbanoo Jahangir, Mohamadreza Baghaban Eslaminejad, Fahimeh Kahyyatan, Hannaneh Safiaghdam, Yeganeh Sadooghi, Majid Safa, Tahereh S. Jafarzadeh Kashi, Erfan Dashtimoghadam, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Objectives

We aim to develop a 3D-bilayer collagen (COL) membrane reinforced with nano beta-tricalcium-phosphate (nβ-TCP) particles and to evaluate its bone regeneration in combination with leukocyte-platelet-rich fibrin (L-PRF) in vivo.

Background data

L-PRF has exhibited promising results as a cell carrier in bone regeneration in a number of clinical studies, however there are some studies that did not confirm the positive results of L-PRF application.

Methods

Mechanical & physiochemical characteristics of the COL/nβ-TCP membrane (1/2 & 1/4) were tested. Proliferation and osteogenic differentiation of seeded cells on bilayer collagen/nβ-TCP thick membrane was examined. Then, critical-sized calvarial defects in 8 …

Applications Of 3d Printing On Craniofacial Bone Repair: A Systematic Review, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren

School of Dentistry Faculty Research and Publications

Objectives

Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region.

Data & sources

A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017.

Study selection

43 …

Applications Of 3d Printing On Craniofacial Bone Repair, Michael Maroulakos, George Kamperos, Lobat Tayebi, Demetrios J. Halazonetis, Yijin Ren

School of Dentistry Faculty Research and Publications

Objectives

Three-dimensional (3D) bioprinting, a method derived from additive manufacturing technology, is a recent and ongoing trend for the construction of 3D volumetric structures. The purpose of this systematic review is to summarize evidence from existing human and animal studies assessing the application of 3D printing on bone repair and regeneration in the craniofacial region.

Data & sources

A rigorous search of all relevant clinical trials and case series was performed, based on specific inclusion and exclusion criteria. The search was conducted in all available electronic databases and sources, supplemented by a manual search, in December 2017.

Study selection

43 …

Effect Of Membrane Exposure On Guided Bone Regeneration: A Systematic Review And Meta‐Analysis, Jeffrey Garcia, Austin Dodge, Paul Luepke, Hom-Lay Wang, Yvonne Kapila, Guo-Hao Lin

School of Dentistry Faculty Research and Publications

Aims: This review aimed at investigating the effect of membrane exposure on guided bone regeneration (GBR) outcomes at peri-implant sites and edentulous ridges.

Material and Methods: Electronic and manual literature searches were conducted by two independent reviewers using four databases, including MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials, for articles up to February 2017. Articles were included if they were human clinical trials or case series reporting outcomes of GBR procedures with and without membrane exposure. A random-effects meta-analysis was conducted, and the weighted mean difference (WMD) between the two groups and 95% confidence interval …

Histological And Immunohistochemical Evaluation Of Biphasic Calcium Phosphate And A Mineral Trioxide Aggregate For Bone Healing In Rat Calvaria, Luis Gustavo Régio De Carvalho Silva, Sung Hyun Kim, Sônia Mara Luczyszyn, Allan Giovanini, Luis Eduardo Almeida, Vinícius Augusto Tramontina

School of Dentistry Faculty Research and Publications

This work focused on the process of bone repair of defects in standardized calvaria of Wistar rats treated with biphasic calcium phosphate (BCP), mineral trioxide aggregate (MTA), or a combination of the two. Eighty Wistar rats were divided into four treatment groups and were examined at 2 and 8 weeks. A surgical defect was created in the calvaria using a 6-mm diameter trephine drill. The cavity was treated with BCP, MTA, or BCP + MTA; untreated rats with clot formation served as controls. Samples were evaluated histologically and by immunohistochemical staining for areas of new osteoid tissue and new bone …