Dental Sealants And Restorative Treatment For First Molars Among Medicaid Enrollees, Christopher Okunseri, Brian D. Hodgson, Elaye Okunseri, Raul Garcia, Alexis D. Visotcky, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objectives

To assess the association between dental sealant placement and subsequent restorative treatment of permanent first molars over time.

Methods

We analysed Wisconsin Medicaid claims data from 2001 to 2009 for children aged 6-16 years. Children entered the study cohort at age 6 and were censored if Medicaid eligibility was lost for >31 days. A fixed effects analysis via a Cox proportional hazards model, stratified by individual, was used to estimate the time-averaged and time-dependent effects of sealant placement on dental treatment defined as any restorative, endodontic or surgical procedure.

Results

A total of 185,262 children with permanent first molars …

A Dynamic Mechanical Method To Assess Bulk Viscoelastic Behavior Of The Dentin Extracellular Matrix, Yvette Alania, Mariana Cavalcante Dos Reis, Joo-Won Nam, Rasika S. Phansalkar, James Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To develop a protocol for assessment of the bulk viscoelastic behavior of dentin extracellular matrix (ECM), and to assess relationships between induced collagen cross-linking and viscoelasticity of the dentin ECM.

Methods

Dentin ECM was treated with agents to induce exogenous collagen cross-linking: proanthocyanidins (PACs) from Vitis vinifera – VVe, PACs from Pinus massoniana - PMe, glutaraldehyde – (GA), or kept untreated (control). A dynamic mechanical strain sweep method was carried out in a 3-point bending submersion clamp at treatment; after protein destabilization with 4 M urea and after 7-day, 6-month, and 12-month incubation in simulated body fluid. Tan δ, …

Serum Levels Of Vitamin C And Vitamin D In A Cohort Of Critically Ill Covid-19 Patients Of A North American Community Hospital Intensive Care Unit In May 2020: A Pilot Study, Cristian Arvinte, Maharaj Singh, Paul E. Marik

School of Dentistry Faculty Research and Publications

Background

The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of vitamin C and vitamin D as a risk-assessment tool, and therapeutic option, in COVID-19.

Objective

The objective of this pilot study was to measure serum vitamin C and vitamin D levels in a cohort of patients with critical COVID-19 illness in our community hospital ICU, correlate with other illness risk factors (age, BMI, HgbA1c, smoking status), generate hypotheses, and …

Epidemiology Of Male Breast Cancer, Santhi Konduri, Maharaj Singh, George Bobustuc, Richard Rovin, Amin Kassam

School of Dentistry Faculty Research and Publications

Background

Due to its rarity, few studies have characterized the epidemiology of male breast cancer. The purpose of this study was to determine survival and risk factors for male breast cancer in a large U.S. population.

Methods

In this study, 19,795 male patients with breast cancer were identified from the National Cancer Database (2004–2014). Patient demographics, tumor characteristics and treatments were analyzed by using descriptive statistics. We used multivariate Cox regression and Kaplan Meier analysis.

Results

Over 10 years, the incidence of male breast cancer increased from 7.2% to 10.3%, while mortality decreased from 11% to 3.8%. Socioeconomic factors predicting …

Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi

School of Dentistry Faculty Research and Publications

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient's quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach …

Graphite/Gold Nanoparticles Electrode For Direct Protein Attachment: Characterization And Gas Sensing Application, Javad Shabani Shayeh, Yahya Sefidbakht, Meisam Omidi, Fatemeh Yazdian, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this work, graphite/gold nanoparticles (G/AuNPs) were synthesized through a facile chemical method, and its potential application for direct protein attachment for electrochemical detection of carbon monoxide (CO) was investigated. The preparation of G/AuNPs electrodes was optimized by synthesizing the nanoparticles in different concentration of HAuCl₄.3H₂O at various temperatures. The G/AuNPs electrode was subsequently modified by four types of mercaptopropionic acid, including 1-mercaptopropionic, 3-mercaptopropionic, 6-mercaptopropionic, and 11-mercaptopropionic acid, to achieve the best structure for protein attachment. Visible absorption and electrochemical studies showed that 3-mercaptopropionic acid possesses the best performance regarding the electrical conductivity between electrode and …

Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites, prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely recognized but poorly understood. With the analysis of evidence that underlies this challenge, this perspective identifies shortcomings in capturing and delineating PAC structures as key factors. While several groups have forwarded new representations, a consensus method that captures PAC structures concisely and offers high integrity for electronic storage is required to reduce confusion in this expansive field. The PAC block arrays (PACBAR) system fills this gap by providing precise and human- and machine-readable structural descriptors that capture PAC metabolomic structural …

Targeting Trimeric And Tetrameric Proanthocyanidins Of Cinnamomum Verum Bark As Bioactives For Dental Therapies, Joo-Won Nam, Rasika S. Phansalkar, David C. Lankin, James Mcalpine, Ariene A. Leme-Kraus, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

The present study elucidated the structures of three A-type tri- and tetrameric proanthocyanidins (PACs) isolated from Cinnamomum verum bark to the level of absolute configuration and determined their dental bioactivity using two therapeutically relevant bioassays. After selecting a PAC oligomer fraction via a biologically diverse bioassay-guided process, in tandem with centrifugal partition chromatography, phytochemical studies led to the isolation of PAC oligomers that represent the main bioactive principles of C. verum: two A-type tetrameric PACs, epicatechin-(2β→O→7,4β→8)-epicatechin-(4β→6)-epicatechin-(2β→O→7,4β→8)-catechin (1) and parameritannin A1 (2), together with a trimer, cinnamtannin B1 (3). Structure …

Drug-Delivery Ca-Mg Silicate Scaffolds Encapsulated In Plga, A. Jadidi, E. Salahinejad, E. Sharifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca₇MgSi₄O₁₆) porous scaffolds were fabricated by a foam replica method, loaded with vancomycin hydrochloride and encapsulated in poly lactic-co-glycolic acid (PLGA) coatings. Field emission scanning electron microscopy, Archimedes porosimetry and Fourier-transform infrared spectroscopy were used to characterize the structure of the scaffolds. The drug delivery kinetics and cytocompatibility of the prepared scaffolds were also studied in vitro. The bare sample exhibited a burst release of vancomycin and low biocompatibility …

Synergistic Effects Of Conductive Pva/Pedot Electrospun Scaffolds And Electrical Stimulation For More Effective Neural Tissue Engineering, Ali Babaie, Behnaz Bakhshandeh, Ali Abedi, Javad Mohammadnejad, Iman Shabani, Abdolreza Ardeshirylajimi, Seyed Reza Moosavi, Javid Amini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Fabrication and optimization of conductive scaffolds capable of inducing proper intercellular connections through electrical signals is critical for neural tissue engineering. In this research, electrospun conductive PVA (Polyvinyl alcohol)/PEDOT(poly(3,4-ethylenedioxythiophene)) scaffolds were fabricated in different compositions. Conductivity of electrospinning solutions and electrospun scaffolds were measured. Morphology and topography, mechanical properties and water contact angle of scaffolds were analyzed. Chemistry of scaffolds were studied using FTIR analysis, while biocompatibility and cellular interactions with scaffolds were tested using MTT assay and cellular attachment and spreading testing. Our results show improvements in PEDOT-containing scaffolds, in terms of physiochemical properties, and cell viability compared to …

A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Abstract

Objective

The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates.

Materials and Methods

Bovine pulp tissue was obtained to determine a benchmark of tissue dissolution. The surface area and mass of samples were held constant while the ratio of gelatin and BSA were varied, ranging from 7.5% to 10% gelatin and 5% BSA. Each sample was placed in an individual test tube that was filled with …

Molar-Incisor Hypomineralization Studies, Azza Tagelsir Ahmed, Brian Hodgson, E. Angeles Martinez-Mier

School of Dentistry Faculty Research and Publications

The problem of demarcated hypomineralization defects of the permanent first molars (molar-incisor hypomineralization [MIH]) has been an emerging issue for oral health professionals around the globe. Yet, the first set of US-based epidemiologic data on MIH took as long as 2 decades from the time when MIH was first described by Weerheijm and colleagues.¹ In response to the June JADA article titled “Prevalence of Molar-Incisor Hypomineralization and Other Enamel Defects and Associated Sociodemographic Determinants in Indiana,” (Tagelsir Ahmed A, Soto-Rojas AE, Dean JA, Eckert GJ, Martinez-Mier EA, JADA. 2020;151[7]: 491-501), we attempt to highlight some of the challenges encountered …

Plga-Coated Drug-Loaded Nanotubes Anodically Grown On Nitinol, F. Davoodian, E. Salahinejad, E. Sharifi, Z. Barabadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This study evaluates the use of nanotubes (NTs) as a matrix for local drug delivery modified by a biodegradable polymeric coating on medical-grade nitinol (NiTi alloy) surfaces. For this purpose, NiTi was anodized within parameters that promote the formation of NTs, ultrasonicated, annealed and impregnated with vancomycin hydrochloride. To improve bioperformance, poly(lactic-co-glycolic acid) (PLGA) was also deposited on the drug-loaded NTs. The samples were characterized in terms of structure, wettability, drug delivery, corrosion and cytocompatibility. Scanning electron microscopy and water contact angle measurements signify the formation of open-top homogeneous NTs of 600– 700 nm in length and ~30 nm in …

Nano-Hydroxyapatite And Nano-Hydroxyapatite/Zinc Oxide Scaffold For Bone Tissue Engineering Application, Fatemeh Heidari, Reza Bazargan-Lari, Mehdi Razavi, Farahnaz Fahimipour, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This research aims to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by ZnO for bone tissue engineering applications. HA and ZnO were developed using sol‐gel and precipitation methods respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), atomic absorption (AA), and atomic force microscopy (AFM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ZnO scaffolds possess higher …

A Tri-Component Knee Plug For The 3rd Generation Of Autologous Chondrocyte Implantation, Lobat Tayebi, Zhanfeng Cui, Hua Ye

School of Dentistry Faculty Research and Publications

Here, we report a newly designed knee plug to be used in the 3rd generation of Autologous Chondrocyte Implantation (ACI) in order to heal the damaged knee cartilage. It is composed of three components: The first component (Bone Portion) is a 3D printed hard scaffold with large pores (~ 850 µm), made by hydroxyapatite and β-tricalcium phosphate to accommodate the bony parts underneath the knee cartilage. It is a cylinder with a diameter of 20 mm and height of 7.5 mm, with a slight dome shape on top. The plug also comprises a Cartilage Portion (component 2) which is a …

Removal Of Water Binding Proteins From Dentin Increases The Adhesion Strength Of Low-Hydrophilicity Dental Resins, Ana Paula Farina, Doglas Cecchin, Cristina M. P. Vidal, Ariene A. Leme-Kraus, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To investigate the role of proteoglycans (PGs) on the physical properties of the dentin matrix and the bond strength of methacrylate resins with varying hydrophilicities.

Methods

Dentin were obtained from crowns of human molars. Enzymatic removal of PGs followed a standard protocol using 1 mg/mL trypsin (Try) for 24 h. Controls were incubated in ammonium bicarbonate buffer. Removal of PGs was assessed by visualization of glycosaminoglycan chains (GAGs) in dentin under transmission electron microscopy (TEM). The dentin matrix swelling ratio was estimated using fully demineralized dentin. Dentin wettability was assessed on wet, dry and re-wetted dentin surfaces through water …

Sublingual Emphysema Following Alveoloplasty: A Case Report, Austin Dodge, Katelyn Kreh, Vrisiis Kofina, Swati Y. Rawal

School of Dentistry Faculty Research and Publications

Various cases of introduction of air into soft tissues have been reported in the dental literature. Here, we report a rare case of localized sublingual emphysema after alveoloplasty. There was no facial involvement. The patient responded to treatment and recovered uneventfully.

Three-Dimensional In Vitro Oral Mucosa Models Of Fungal And Bacterial Infections, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Oral mucosa is the target tissue for many microorganisms involved in periodontitis and other infectious diseases affecting the oral cavity. Three-dimensional (3D) in vitro and ex vivo oral mucosa equivalents have been used for oral disease modeling and investigation of the mechanisms of oral bacterial and fungal infections. This review was conducted to analyze different studies using 3D oral mucosa models for the evaluation of the interactions of different microorganisms with oral mucosa. In this study, based on our inclusion criteria, 43 articles were selected and analyzed. Different types of 3D oral mucosa models of bacterial and fungal infections were …

Bonding Crowns And Bridges With Resin Cement, Nathaniel C. Lawson, Sharukh Khajotia, Ana K. Bedran-Russo, Kevin Frazier, Jacob Park, Ariene A. Leme-Kraus, Olivia Urquhart

School of Dentistry Faculty Research and Publications

Background

Bonding crowns and bridges with resin cement can improve retention and reinforcement of the restoration. However, there is variation in the steps taken by different practitioners to achieve this goal.

Methods

The authors developed a survey on bonding dental crowns and bridges with resin cement and distributed it electronically to the American Dental Association Clinical Evaluators (ACE) Panel on May 22, 2020. The survey remained open for 2 weeks. Descriptive data analysis was conducted using SAS Version 9.4.

Results

A total of 326 panelists responded to the survey, and 86% of respondents who place crowns or bridges use resin …

Fibroblast Encapsulation In Gelatin Methacryloyl (Gelma) Versus Collagen Hydrogel As Substrates For Oral Mucosa Tissue Engineering, Fahimeh Tabatabaei, Keyvan Moharamzadeh, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Purpose

Over the past decades, a variety of biomaterials have been investigated in terms of their suitability for oral mucosa tissue engineering. The aim of this study was to compare collagen and GelMA hydrogels as connective tissue scaffolds for fibroblasts and as substrates for seeding and culture of oral epithelial keratinocyte cells.

Methods

Human primary oral fibroblast and keratinocyte cells were isolated from gingival biopsies. The mixture of fibroblasts with GelMA or collagen gel were aliquoted within six-well tissue culture plate inserts and cross-linked using visible light or reconstitution buffer/heat, respectively. The viability of fibroblasts in the hydrogels was investigated …

Carbosilane Dendrimers: Drug And Gene Delivery Applications, Navid Rabiee, Shokooh Ahmadvand, Sepideh Ahmadi, Yousef Fatahi, Rassoul Dinarvand, Mojtaba Bagherzadeh, Mohammad Rabiee, Mohammadreza Tahriri, Lobat Tayebi, Michael R. Hamblin

School of Dentistry Faculty Research and Publications

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as delivery vehicles for drugs and nucleic acids. They have a defined structure according to their generation number, and their terminal groups can be rendered cationic or anionic. The cationic charges can address the limitation of electrostatic repulsion between the negatively charged phosphate groups of nucleic acids and negatively charged cell membranes. Specific drugs can be loaded into the central part of the dendrimer or attached at the exterior, and the overall positive charge may improve the efficacy of anti-inflammatory drugs. One promising feature of dendrimers is …

Aptamer-Conjugated Plga Nanoparticles For Delivery And Imaging Of Cancer Therapeutic Drugs, Maryam Hashemi, Azarmidokht Shamshiri, Majid Saeedi, Lobat Tayebi, Rezvan Yazdian-Robati

School of Dentistry Faculty Research and Publications

Most problems associated with chemotherapeutic agents involve non-specific cytotoxicity, low intratumoral accumulation and drug resistance. Targeted drug delivery systems (TDDS) based on nanoparticles (NPs) are a new strategy for better therapeutic efficiency, along with reduction of side effects commonly seen with cancer drugs. Poly (lactic-co-glycolic acid) (PLGA), as one of the furthest developed synthetic polymer, has gained significant attention because of excellent properties—including biodegradability and biocompatibility, controlled release of drug, protection of drug or gene from decomposition and ability to modify surface with targeting agents for both cancer diagnosis and therapy. Aptamers are single-stranded RNA or DNA that can fold …

Shedding Light On The Role Of Keratinocyte-Derived Extracellular Vesicles On Skin-Homing Cells, Golara Nasiri, Negar Azarpira, Aliakbar Alizadeh, Sanaz Goshtasbi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Extracellular vesicles (EVs) are secretory lipid membranes with the ability to regulate cellular functions by exchanging biological components between different cells. Resident skin cells such as keratinocytes, fibroblasts, melanocytes, and inflammatory cells can secrete different types of EVs depending on their biological state. These vesicles can influence the physiological properties and pathological processes of skin, such as pigmentation, cutaneous immunity, and wound healing. Since keratinocytes constitute the majority of skin cells, secreted EVs from these cells may alter the pathophysiological behavior of other skin cells. This paper reviews the contents of keratinocyte-derived EVs and their impact on fibroblasts, melanocytes, and …

A Review On The Biodistribution, Pharmacokinetics And Toxicity Of Bismuth-Based Nanomaterials, Samireh Badrigilan, Fatemeh Heydarpanahi, Jalal Choupani, Mehdi Jaymand, Hadi Samadian, Mojtaba Hoseini-Ghahfarokhi, Thomas J. Webster, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Here, bismuth-based nanomaterials (Bi-based NMs) are introduced as promising theranostic agents to enhance image contrast as well as for the therapeutic gain for numerous diseases. However, understanding the interaction of such novel developed nanoparticles (NPs) within a biological environment is a requisite for the translation of any promising agent from the lab bench to the clinic. This interaction delineates the fate of NPs after circulation in the body. In an ideal setting, a nano-based therapeutic agent should be eliminated via the renal clearance pathway, meanwhile it should have specific targeting to a diseased organ to reach an effective dose and …

Magnetic Dual-Template Molecularly Imprinted Polymer Based On Syringe-To-Syringe Magnetic Solid-Phase Microextraction For Selective Enrichment Of P-Coumaric Acid And Ferulic Acid From Pomegranate, Grape, And Orange Samples, Ebrahim Alipanahpour Dil, Mehrorang Ghaedi, Arash Asfaram, Fatemah Mehrabi, Ardeshir Shokrollahi, Amir Abbas Matin, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Magnetic dual-template molecularly imprinted polymer (Fe₃O₄@SiO₂-MDMIP) was prepared to enrich and determine both p-Coumaric acid (p-CA) and ferulic acid (FA) based on syringe-to-syringe magnetic solid-phase microextraction (SS-MSPME). The obtained MDMIP was characterized and recognized, and then its adsorbing performance was studied. Based on the results, the Fe₃O₄@SiO₂-MDMIP indicated selective recognition towards p-CA and FA with large adsorption capacity. The optimization of MDMIP–SS-MSPME conditions (pH, Fe₃O₄@SiO₂-MDMIP mass, NaCl concentration, number of cycle, and elution volume) were conducted using the central composite design (CCD). …

Biomineralization, Strength And Cytocompatibility Improvement Of Bredigite Scaffolds Through Doping/Coating, R. Keihan, A. R. Ghorbani, E. Salahinejad, E. Sharifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Coprecipitation-derived, sacrificial polymeric (urethane) foam-fabricated bredigite (Ca₇MgSi₄O₁₆) scaffolds were processed by individual and combined treatments of fluoride doping and poly (lactic-co-glycolic acid) (PLGA) coating and then studied in terms of structure, mechanical strength, bioactivity and cell biocompatibility in vitro. According to scanning electron microscopy and Archimedes porosimetry, the geometrical characteristics of pores for all the scaffolds are in the appropriate range for hard tissue regeneration applications. The apatite-formation ability of the samples immersed in a simulated body fluid is improved by doping for both the bare and coated conditions, based on …

Evaluation Of Mechanical And Biocompatibility Properties Of Hydroxyapatite/Manganese Dioxide Nanocomposite Scaffolds For Bone Tissue Engineering Application, Fatemeh Azizi, Fatemeh Heidari, Farahnaz Fahimipour, Mohammad Sajjadnejad, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this research was to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by MnO₂ for bone tissue engineering applications. HA and MnO₂ were developed using sol‐gel and precipitation methods, respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microcopy (SEM), energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ MnO₂ scaffolds possess higher …

Effect Of Fabrication Method On The Structure And Properties Of A Nanostructured Nickel-Free Stainless Steel, L. Heidari, A. Tangestani, M. J. Hadianfard, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

An ASTM F2581 nanostructured stainless steel was fabricated by two different powder metallurgy routes; Hot Powder Forging (HPF) and Binder Assisted Extrusion (BAE) methods. Their structure and mechanical properties were investigated and compared. In both fabrication methods, the alloy powder was made by using main alloying elements through mechanical alloying, along with the addition of a sintering aid. In the BAE method, a paste was prepared by mixing alloy powders with polymer followed by cold extrusion, polymer removal, and sintering. In the HPF method, the alloy powders were hot forged under high pressure. The structure and the size of the …

Left Ventricular Global And Regional Deformation In Arrhythmic Myxomatous Bileaflet Mitral Valve Prolapse Syndrome, Lakshmi Muthukumar, Arshad Jahangir, M. Faud Jan, Patrycja Galazka, Matt Umland, Mckenzie R. Schweitzer, Ana Cristina Perez Moreno, Maharaj Singh, Bijoy K. Khandheria, A. Jamil Tajik

School of Dentistry Faculty Research and Publications

No abstract provided.

Effect Of Dentin Biomodification Delivered By Experimental Acidic And Neutral Primers On Resin Adhesion, Lívia Tosi Trevelin, Yvette Alania, Mathew Mathew, Rasika S. Phansalkar, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

Proanthocyanidins (PACs) are biocompounds mimicking native collagen cross-links. The effective and practical delivery of any biocompound is pivotal for clinical usage. The aim was to investigate the dentin biomodification and effective formation of dentin–resin biointerfaces of two highly bioactive PAC-rich extracts, Vitis vinifera (Vv) and Camellia sinensis (Cs), delivered using neutral (NP) or acidic (AP) rinse-out primer approaches.

Methods

The depth of dentin demineralization (optical profilometry), dentin biomodification (apparent modulus of elasticity, collagen auto-fluorescence) and properties of dentin–resin interfaces (microtensile bond strength - μTBS, and micro-permeability) were investigated. NP consisted of either 15% Vv or Cs applied for …