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Full-Text Articles in Medicine and Health Sciences
Bidirectional Psychoneuroimmune Interactions In The Early Postpartum Period Influence Risk Of Postpartum Depression, Elizabeth J. Corwin, Kathleen Pajer, Sudeshna Paul, Nancy Lowe, Mary Weber, Donna O. Mccarthy
Bidirectional Psychoneuroimmune Interactions In The Early Postpartum Period Influence Risk Of Postpartum Depression, Elizabeth J. Corwin, Kathleen Pajer, Sudeshna Paul, Nancy Lowe, Mary Weber, Donna O. Mccarthy
College of Nursing Faculty Research and Publications
More than 500,000 U.S. women develop postpartum depression (PPD) annually. Although psychosocial risks are known, the underlying biology remains unclear. Dysregulation of the immune inflammatory response and the hypothalamic–pituitary–adrenal (HPA) axis are associated with depression in other populations. While significant research on the contribution of these systems to the development of PPD has been conducted, results have been inconclusive. This is partly because few studies have focused on whether disruption in the bidirectional and dynamic interaction between the inflammatory response and the HPA axis together influence PPD. In this study, we tested the hypothesis that disruption in the inflammatory-HPA axis …
Differences In Inflammatory Markers Between Nulliparous Women Admitted To Hospitals In Preactive Vs Active Labor, Jeremy L. Neal, Jane M. Lamp, Nancy Lowe, Shannon L. Gillespie, Loraine T. Sinnott, Donna O. Mccarthy
Differences In Inflammatory Markers Between Nulliparous Women Admitted To Hospitals In Preactive Vs Active Labor, Jeremy L. Neal, Jane M. Lamp, Nancy Lowe, Shannon L. Gillespie, Loraine T. Sinnott, Donna O. Mccarthy
College of Nursing Faculty Research and Publications
Objective
To determine whether labor-associated inflammatory markers differ between low-risk, nulliparous women in preactive vs active labor at hospital admission and over time.
Study Design
Prospective comparative study of low-risk, nulliparous women with spontaneous labor onset at term (n = 118) sampled from 2 large Midwestern hospitals. Circulating concentrations of inflammatory markers were measured at admission and again 2 and 4 hours later: namely, neutrophil, and monocyte counts; and serum inflammatory cytokines (interleukin -1β, interleukin-6, tumor necrosis factor-α, interleukin-10) and chemokines (interleukin-8). Biomarker concentrations and their patterns of change over time were compared between preactive (n = 63) and active …