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Full-Text Articles in Medicine and Health Sciences
Losartan Treatment Attenuates Tumor-Induced Myocardial Dysfunction, Sarah C.W. Stevens, Markus Velten, Dane J. Youtz, Yvonne Clark, Runfeng Jing, Peter J. Reiser, Sabahattin Bicer, Raymond D. Devine, Donna O. Mccarthy, Loren E. Wold
Losartan Treatment Attenuates Tumor-Induced Myocardial Dysfunction, Sarah C.W. Stevens, Markus Velten, Dane J. Youtz, Yvonne Clark, Runfeng Jing, Peter J. Reiser, Sabahattin Bicer, Raymond D. Devine, Donna O. Mccarthy, Loren E. Wold
College of Nursing Faculty Research and Publications
Fatigue and muscle wasting are common symptoms experienced by cancer patients. Data from animal models demonstrate that angiotensin is involved in tumor-induced muscle wasting, and that tumor growth can independently affect myocardial function, which could contribute to fatigue in cancer patients. In clinical studies, inhibitors of angiotensin converting enzyme (ACE) can prevent the development of chemotherapy-induced cardiovascular dysfunction, suggesting a mechanistic role for the renin–angiotensin–aldosterone system (RAAS). In the present study, we investigated whether an angiotensin (AT) 1-receptor antagonist could prevent the development of tumor-associated myocardial dysfunction. Methods and results: Colon26 adenocarcinoma (c26) cells were implanted into female CD2F1 mice …
Storage Conditions And Passages Alter Il-6 Secretion In C26 Adenocarcinoma Cell Lines, Diana M. Norden, Raymond Devine, Donna O. Mccarthy, Loren E. Wold
Storage Conditions And Passages Alter Il-6 Secretion In C26 Adenocarcinoma Cell Lines, Diana M. Norden, Raymond Devine, Donna O. Mccarthy, Loren E. Wold
College of Nursing Faculty Research and Publications
The C26 adenocarcinoma tumor line is frequently used to establish peripheral tumors in mice for the study of cancer cachexia and cancer-related fatigue. Recently, we have noticed a progressive decline in the effects of tumor growth on our biological and behavioral measures in the tumor-bearing mice. Therefore, we compared effects of three aliquots of the C26 tumor cell line that differed in storage condition and number of passages on cytokine secretion, tumor growth, weight loss and fatigue behavior. Three aliquots of the C26 tumor line were selected as alpha (α), beta (β), and gamma (γ). Aliquot α was an original …