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Myocardial Dysfunction In An Animal Model Of Cancer Cachexia, Hui Xu, Danielle Crawford, Kirk R. Hutchinson, Dane J. Youtz, Pamela A. Lucchesi, Markus Velten, Donna O. Mccarthy, Loren E. Wold

College of Nursing Faculty Research and Publications

Aims

Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease. In rodents, tumor-induced fatigue is associated with a progressive loss of skeletal muscle mass and increased expression of biomarkers of muscle protein degradation. The purpose of the present study was to determine if muscle wasting and expression of biomarkers of muscle protein degradation occur in the hearts of tumor-bearing mice, and if these effects of tumor growth are associated with changes in cardiac function.

Main methods

The colon26 adenocarcinoma cell line was …