Medicine and Health Sciences Commons^™

Folic Acid Supplementation Improves Vascular Function In Professional Dancers With Endothelial Dysfunction, Anne Z. Hoch, Paula Papanek, Aniko Szabo, Michael E. Widlansky, David D. Gutterman

Exercise Science Faculty Research and Publications

Objective

To determine if folic acid supplementation improves vascular function (brachial artery flow-mediated dilation [FMD]) in professional dancers with known endothelial dysfunction.

Design

Prospective cross-sectional study.

Setting

Academic institution in the Midwestern United States.

Subjects

Twenty-two professional ballet dancers volunteered for this study.

Main Outcome Measures

Subjects completed a 3-day food record to determine caloric and micronutrient intake. Menstrual status was determined by interview and questionnaire. Endothelial function was determined as flow-induced vasodilation measured by high-frequency ultrasound of the brachial artery. A change in brachial diameter of

Results

Sixty-four percent of dancers (n = 14) had abnormal brachial artery FMD …

Effect Of Animal Facility Construction On Basal Hypothalamic-Pituitary-Adrenal And Renin-Aldosterone Activity In The Rat, Hershel Raff, Eric D. Bruder, William E. Cullinan, Dana R. Ziegler, Eric P. Cohen

Biomedical Sciences Faculty Research and Publications

Nearby construction can cause subtle, but important activation of the hypothalamic-pituitary-adrenal axis in laboratory rats.

Although loud noise and intense vibration are known to alter the behavior and phenotype of laboratory animals, little is known about the effects of nearby construction. We studied the effect of a nearby construction project on the classic stress hormones ACTH, corticosterone, renin, and aldosterone in rats residing in a barrier animal facility before, for the first 3 months of a construction project, and at 1 month after all construction was completed. During some of the construction, noise and vibrations were not obvious to investigators …

Dog Models Of Naturally Occurring Cancer, Donna O. Mccarthy

College of Nursing Faculty Research and Publications

Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has a vastly reduced genetic variation compared with humans; this simplifies disease mapping and pharmacogenomics. Dogs age five- to eight-fold faster than do humans, share environments with their owners, are usually kept until old age and receive a high level of health care. Farseeing investigators recognized this potential and, over …