Medicine and Health Sciences Commons^™

Μ-Opioid Receptor Agonist Injections Into The Presumed Pre-Bötzinger Complex And The Surrounding Region Of Awake Goats Do Not Alter Eupneic Breathing, K. L. Krause, Suzanne E. Neumueller, B. D. Marshall, T. Kiner, Joshua M. Bonis, Lawrence Pan, B. Qian, Hubert V. Forster

Physical Therapy Faculty Research and Publications

Opioids are clinically important in the alleviation of pain. An undesirable side effect of opioids is depression of breathing. Data from isolated preparations suggest this effect is due to attenuation of discharge activity of neurons in the pre-Bötzinger complex (preBötzC), a medullary area with respiratory rhythmogenic properties. The purpose of this study was to examine how [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO), a μ-opioid receptor agonist, affected breathing after injection into the presumed preBötzC of the adult awake goat. We hypothesized that DAMGO would cause breathing to decrease and become irregular when injected into the presumed preBötzC and the surrounding region of the conscious …

Observation Of Amounts Of Movement Practice Provided During Stroke Rehabilitation, Catherine E. Lang, Jillian R. Macdonald, Darcy S. Reisman, Lara Boyd, Teresa Jacobson Kimberley, Sheila M. Schindler-Ivens, T. George Hornby, Sandy A. Ross, Patricia L. Scheets

Physical Therapy Faculty Research and Publications

Objective

To investigate how much movement practice occurred during stroke rehabilitation, and what factors might influence doses of practice provided.

Design

Observational survey of stroke therapy sessions.

Setting

Seven inpatient and outpatient rehabilitation sites.

Participants

We observed a convenience sample of 312 physical and occupational therapy sessions for people with stroke.

Interventions

Not applicable.

Main Outcome Measures

We recorded numbers of repetitions in specific movement categories and data on potential modifying factors (patient age, side affected, time since stroke, FIM item scores, years of therapist experience). Descriptive statistics were used to characterize amounts of practice. Correlation and regression analyses were …

Elastic, Viscous, And Mass Load Effects On Poststroke Muscle Recruitment And Co-Contraction During Reaching: A Pilot Study, Tina M. Stoeckmann, Katherine J. Sullivan, Robert A. Scheidt

Biomedical Engineering Faculty Research and Publications

Background: Resistive exercise after stroke can improve strength (force-generating capacity) without increasing spasticity (velocity-dependent hypertonicity). However, the effect of resistive load type on muscle activation and co-contraction after stroke is not clear.

Objective: The purpose of this study was to determine the effect of load type (elastic, viscous, or mass) on muscle activation and co-contraction during resisted forward reaching in the paretic and nonparetic arms after stroke.

Design: This investigation was a single-session, mixed repeated-measures pilot study.

Methods: Twenty participants (10 with hemiplegia and 10 without neurologic involvement) reached forward with each arm against equivalent elastic, viscous, and mass loads. …

Normal Breathing Pattern And Arterial Blood Gases In Awake And Sleeping Goats After Near Total Destruction Of The Presumed Pre-Bötzinger Complex And The Surrounding Region, Katie L. Krause, Hubert Forster, T. Kiner, S. E. Davis, Joshua M. Bonis, B. Qian, Lawrence Pan

Physical Therapy Faculty Research and Publications

Abrupt neurotoxic destruction of >70% of the pre-Bötzinger complex (preBötzC) in awake goats results in respiratory and cardiac failure (Wenninger JM, Pan LG, Klum L, Leekley T, Bastastic J, Hodges MR, Feroah TR, Davis S, Forster HV. J Appl Physiol 97: 1629–1636, 2004). However, in reduced preparations, rhythmic respiratory activity has been found in other areas of the brain stem (Huang Q, St. John WM. J Appl Physiol 64: 1405–1411, 1988; Janczewski WA, Feldman JL. J Physiol 570: 407–420, 2006; Lieske SP, Thoby-Brisson M, Telgkamo P, Ramierz JM. Nature Neurosci 3: 600–607, 2000; St. John WM, Bledsoe TA. J Appl …

Does Plasma Ss-Endorphin Influence Exercise-Induced Hypoalgesia In Healthy Adults?, Kathy Lemley

Maria Dittman Library Research Competition: Student Award Winners

Anecdotal reports can be found in the literature of athletes who suffer from an injury, yet continue to participate in their sport with little or no pain. These reports have resulted in an interest in the possible role of stress, including exercise, in analgesia. Exercise-induced hypoalgesia (EIH), a decrease in pain perception following exercise, has been found to occur in healthy adults. In the 1970’s opioid peptides with analgesic properties were discovered (Dalayeun, Nores & Bergal, 1993). One of these peptides, β-endorphin, is believed to be released from the anterior pituitary into the circulation under a variety of stressors, including …