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Hierarchical Cluster Analysis Of Myoepithelial/Basal Cell Markers In Adenoid Cystic Carcinoma And Polymorphous Low-Grade Adenocarcinoma, Manju L. Prasad, Catalin C. Barbacioru, Yeshwant B. Rawal, Omar Husein, Ping Wen

School of Dentistry Faculty Research and Publications

Distinguishing adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma of the salivary glands is important for their management. We studied the expression of several myoepithelial and basal/stem cell markers (smooth muscle actin, calponin, smooth muscle myosin heavy chain, metallothionein, maspin, and p63) by immunohistochemistry in 23 adenoid cystic carcinoma and 24 polymorphous low-grade adenocarcinoma, to identify the most useful marker or combination of markers that may help their diagnoses. The results were analyzed using hierarchical cluster analysis and χ² test for trend. We noted diffuse expression of smooth muscle actin in 20 adenoid cystic carcinoma vs one polymorphous low-grade adenocarcinoma …